ID A0A084W8H3_ANOSI Unreviewed; 1427 AA.
AC A0A084W8H3;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN ORFNames=ZHAS_00014509 {ECO:0000313|EMBL:KFB46517.1};
OS Anopheles sinensis (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=74873 {ECO:0000313|EMBL:KFB46517.1};
RN [1] {ECO:0000313|EMBL:KFB46517.1, ECO:0000313|Proteomes:UP000030765}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24438588; DOI=10.1186/1471-2164-15-42;
RA Zhou D., Zhang D., Ding G., Shi L., Hou Q., Ye Y., Xu Y., Zhou H.,
RA Xiong C., Li S., Yu J., Hong S., Yu X., Zou P., Chen C., Chang X., Wang W.,
RA Lv Y., Sun Y., Ma L., Shen B., Zhu C.;
RT "Genome sequence of Anopheles sinensis provides insight into genetics basis
RT of mosquito competence for malaria parasites.";
RL BMC Genomics 15:42-42(2014).
RN [2] {ECO:0000313|EnsemblMetazoa:ASIC014509-PA}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. TKL Ser/Thr
CC protein kinase family. {ECO:0000256|ARBA:ARBA00005843}.
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DR EMBL; ATLV01021433; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ATLV01021434; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KE525318; KFB46517.1; -; Genomic_DNA.
DR STRING; 74873.A0A084W8H3; -.
DR EnsemblMetazoa; ASIC014509-RA; ASIC014509-PA; ASIC014509.
DR VEuPathDB; VectorBase:ASIC014509; -.
DR VEuPathDB; VectorBase:ASIS016024; -.
DR OMA; RKCRPFG; -.
DR Proteomes; UP000030765; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR CDD; cd09365; LIM2_LIMK; 1.
DR CDD; cd00992; PDZ_signaling; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.10.110.10; Cysteine Rich Protein; 2.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR001781; Znf_LIM.
DR PANTHER; PTHR46485; LIM DOMAIN KINASE 1; 1.
DR PANTHER; PTHR46485:SF4; LIM DOMAIN KINASE 1; 1.
DR Pfam; PF00412; LIM; 2.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00132; LIM; 2.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 2.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00478; LIM_DOMAIN_1; 2.
DR PROSITE; PS50023; LIM_DOMAIN_2; 2.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW LIM domain {ECO:0000256|ARBA:ARBA00023038, ECO:0000256|PROSITE-
KW ProRule:PRU00125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW ProRule:PRU00125};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Reference proteome {ECO:0000313|Proteomes:UP000030765};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00125}.
FT DOMAIN 20..79
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT DOMAIN 81..140
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT DOMAIN 184..263
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 375..654
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 1033..1162
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1241..1260
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1266..1331
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1054..1078
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1103..1162
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 404
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 1427 AA; 153932 MW; E64C746D4F37EE2F CRC64;
MPKGDGGAGQ RSGGGKKDST ACASCYNAIE PEQHVAAVGQ LWHAECFRCS VCDARLSSWY
FEKDGLLFCK EDHWSKFGDC CQQCSQIISG PVMFAGDHKF HSECFRCESC KVFIAEGETY
TLLERSKLYC GQCYKRHQSA FVEVSRNGTT TTSSLVRGEK AKQQPLPHTI RLVEIPWTNA
RTDRIRLATD DKLFGASGKG AGAGCKSVRI SEVTLNSDLM SLRVGDKVLE VNGTPVRDVP
LENLQNLIEN SAGKVLQLTV EHDPELVDQQ QQQRSVNGVL SASYCGTQCP DTCNNNEDED
NQSSRSLSPS KLERIFRKND EGYMSGSSRK LQKRLKDVNC NTGSIAAGGE FYDLSRTKSF
RVEPKAARIF RASDLVQGEL LGKGFFGQVF KVTHRVTQEV MVLKELYRVD EEAQKNFLKE
VAVLRSLSHH NVLRFIGVLY KDKKLHLVTE FIPGGSLKEL IHDSGQPLSW EQRISFARDI
SCGMSYLHSM NIIHRDLNSL NCLVREDGTV IVADFGLARI IKQPLLSTAY EKCSASAATP
GNGNGTIGRR GRPRRQRYTV VGNPYWMAPE MMRGNKYDEK VDIFSFGIML CEIIGRVQAD
PDYLPRLPDF GLNQTVFREK FCGQCPEPFF KIAFLCCDLN PDKRPPFHVL QDWLETMVTM
TALNKPLPAK IVYDIEHFKG QRSTDSSLCT TPDGLATPPP SAGYSLKPSL SRKRICEGPE
DTVEPQPKLS DLQTTSSLDV VDGVIGVGVR PPTVENNATP CCPDATNGFI VADCIEIPKS
PHLGKDFSAN GDRIRDSIRA KRRHRMMLSR ENQRKSLDSS VLAARLGSDR LFADVNDVAD
NGSASEPISL IMTSEMIAND AAKIAEATAG GRRERPSTDE LLASVKDSLE LNKSLIGAGG
DGIRPNNGAW GPVPAKVKHY GEKGFVIHVQ NGHLTLNNVR DLENCSDFDS SCDTSLNYIE
VNGNRMESES CETPEVEVKC DTVVSSGVGG VAVTSCPPPP LEPVHLSRGT CEKENISTES
PPLTVLGKAK ITPTQSKPNF SPFAPIPPER NGSIGNGTLP TKVEEKKQPS SAQKAVQYTR
KLFRSAMEPS GNTSKPVHDL PGTHLPSSTT KGTPSSRGHT RTSSSERSAL FSTKQKISPT
SDPEPQPSFG VTGAGSSARP KSNTVLNSVF SYKSKPNEPS VDGARVAQGG NVFAASGSTI
RRVGAKGSVG GKASPGGVMN AACVESIPPA TGKPPIGTYT PAALAGSGSP GSSILRFGKS
TRTYRPVEKM TTVSGESRTA TGVRVEKYTT FSPPSGSSGS NSRTDSPSPP VPNGTRSSIG
GTAGSRTIGI LSPSSIRRLN ARLLEARKGN GTFGSEQPTP TPVVPRTKVA TIVSISGGTK
LPGVARKVPP VTTSSSGASR GTILSAVAGC SRERRSTRCP GGPHMGV
//
