ID A0A084WBC9_ANOSI Unreviewed; 1265 AA.
AC A0A084WBC9;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE RecName: Full=MIF4G domain-containing protein {ECO:0000259|SMART:SM00543};
GN ORFNames=ZHAS_00015483 {ECO:0000313|EMBL:KFB47523.1};
OS Anopheles sinensis (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=74873 {ECO:0000313|EMBL:KFB47523.1};
RN [1] {ECO:0000313|EMBL:KFB47523.1, ECO:0000313|Proteomes:UP000030765}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24438588; DOI=10.1186/1471-2164-15-42;
RA Zhou D., Zhang D., Ding G., Shi L., Hou Q., Ye Y., Xu Y., Zhou H.,
RA Xiong C., Li S., Yu J., Hong S., Yu X., Zou P., Chen C., Chang X., Wang W.,
RA Lv Y., Sun Y., Ma L., Shen B., Zhu C.;
RT "Genome sequence of Anopheles sinensis provides insight into genetics basis
RT of mosquito competence for malaria parasites.";
RL BMC Genomics 15:42-42(2014).
RN [2] {ECO:0000313|EnsemblMetazoa:ASIC015483-PA}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; ATLV01022343; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KE525331; KFB47523.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A084WBC9; -.
DR STRING; 74873.A0A084WBC9; -.
DR EnsemblMetazoa; ASIC015483-RA; ASIC015483-PA; ASIC015483.
DR VEuPathDB; VectorBase:ASIC015483; -.
DR VEuPathDB; VectorBase:ASIS005719; -.
DR OMA; DFQHHQI; -.
DR Proteomes; UP000030765; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:InterPro.
DR Gene3D; 1.25.40.180; -; 3.
DR Gene3D; 4.10.80.160; -; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR003890; MIF4G-like_typ-3.
DR InterPro; IPR039762; Nmd2/UPF2.
DR InterPro; IPR007193; Upf2/Nmd2_C.
DR PANTHER; PTHR12839; NONSENSE-MEDIATED MRNA DECAY PROTEIN 2 UP-FRAMESHIFT SUPPRESSOR 2; 1.
DR PANTHER; PTHR12839:SF7; REGULATOR OF NONSENSE TRANSCRIPTS 2; 1.
DR Pfam; PF02854; MIF4G; 3.
DR Pfam; PF04050; Upf2; 1.
DR SMART; SM00543; MIF4G; 3.
DR SUPFAM; SSF48371; ARM repeat; 3.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000030765}.
FT DOMAIN 94..321
FT /note="MIF4G"
FT /evidence="ECO:0000259|SMART:SM00543"
FT DOMAIN 516..705
FT /note="MIF4G"
FT /evidence="ECO:0000259|SMART:SM00543"
FT DOMAIN 720..953
FT /note="MIF4G"
FT /evidence="ECO:0000259|SMART:SM00543"
FT REGION 1..54
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 452..507
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 994..1107
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1124..1161
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1223..1265
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..24
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 25..40
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 452..475
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1027..1047
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1063..1093
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1265 AA; 143856 MW; 3A9E850302BE2D9F CRC64;
MSQECTKALD KLTLEGDKKD GTNPAPNTEA ESQDPQDVDG SKTNAEQEEA ERNELQAFVE
SQQERYQQKA AQRQLNQAPE RPAEEDFFRY DSSVKKNTAF VKRLKQFTAQ QLPSLMQDVS
NLNLTKYISE VSAALIEVKL KMSDIAAAVS LCSYLHQTYA DFAPTLFENW QKALLIKPGE
KVANLSKMRV DLRFYAELIS IGIFSNKLGL PLLGACLTGL ITQDKEEHVN LSIVLSFCKH
CGDEYAGLVP IRMTELAKKY GVSIPMSQLL PADKQGNLRN LLKDYYHSLA DHLKKEHKQL
QLAEKSKRKM LQTKGEITAE KREQLAQLQA SYEKLFASTS TLADLLGQAM PELVVEPDSR
DPLEGTVLDG KGGEEMQFAN LDPWRDDETK SFYVDLPDLR LFLPNYCGKK MQEAASQPDD
EYDGGDVVDM LAEPPITEEA LDMDMPELEA DGGELEPAEQ EQEEIVGDEG DPLGEMVDQG
ESAGNADGES GTGLLKPDGS GSCGTPNSQA NRKYFEQYVQ NLQNCVNREL IDNAAIDFLL
NLNTKSKRKR LVKVLFGVQR TRLDLLPMYA RLVAIIDLVS PDVGNELCQM LKIDFKYHLK
KKDQINIETK IKVVRYIGEL VKFGIYKKLE ALYCLRCMLL SFQHHHIEMT CAFLEVCGVY
LYNCPESRMR TNAFLEQMMR LKMNTTMHGR HAQQVENCYY LVKRPERLKV TRKVRPLIHN
YIRHLIYKEL DKSNVDKMIK LLRRLDWGDP STFTYAVRCL SKAYNIRYHL IRSLADLLAG
LNSYQERAVV RVLDTVFEDV RAGLEIHDNK LAQRRVAMVK YLGELYNYQL VDSNTILNTL
YSIISFGVSL THDGPPSAVD PPESLFRLKL ACVLLDTSGQ YFVSGANRKR LDYFLVFFQQ
YYWFKKSHPF FAGSAGVGSD AGLTTGIVSG AKDLFPILID HMYRECLKAL RPKLKLFTSF
EQAKEAVQKL RQQIYPAEEL EKQMRKDELV AAQGLTTTGT SDAPDSSDRE DSTMQSDECT
SDAGEDMSEC YEPKRPHSSR TVGDEDEDDT TTPPAADSGD LDGLECYNDD EEEEDDDENE
DEEDEDEQDF DLEVAVEPMP PPAVKQPEDL EFEREFERMA SECIQQRAKE SSKVNPKQVP
VPVTFRNETK KSYDQLQEPT VEKPDTVPFA LMIRGKGKQQ VYKTFEAPED SQLAQYIREQ
ERKQQEEKDN VKRLTLNISE RLEEEDYQES LNQPTRTADP LRMRPLKPAK FKHPKGVPDI
DAIFH
//
