ID A0A084WC80_ANOSI Unreviewed; 999 AA.
AC A0A084WC80;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE SubName: Full=AGAP010351-PA-like protein {ECO:0000313|EMBL:KFB47824.1};
GN ORFNames=ZHAS_00015876 {ECO:0000313|EMBL:KFB47824.1};
OS Anopheles sinensis (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=74873 {ECO:0000313|EnsemblMetazoa:ASIC015876-PA, ECO:0000313|Proteomes:UP000030765};
RN [1] {ECO:0000313|EMBL:KFB47824.1, ECO:0000313|Proteomes:UP000030765}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24438588; DOI=10.1186/1471-2164-15-42;
RA Zhou D., Zhang D., Ding G., Shi L., Hou Q., Ye Y., Xu Y., Zhou H.,
RA Xiong C., Li S., Yu J., Hong S., Yu X., Zou P., Chen C., Chang X., Wang W.,
RA Lv Y., Sun Y., Ma L., Shen B., Zhu C.;
RT "Genome sequence of Anopheles sinensis provides insight into genetics basis
RT of mosquito competence for malaria parasites.";
RL BMC Genomics 15:42-42(2014).
RN [2] {ECO:0000313|EnsemblMetazoa:ASIC015876-PA}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase M16 family.
CC {ECO:0000256|ARBA:ARBA00007261, ECO:0000256|RuleBase:RU004447}.
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DR EMBL; ATLV01022583; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KE525334; KFB47824.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A084WC80; -.
DR STRING; 74873.A0A084WC80; -.
DR MEROPS; M16.A09; -.
DR EnsemblMetazoa; ASIC015876-RA; ASIC015876-PA; ASIC015876.
DR VEuPathDB; VectorBase:ASIC015876; -.
DR VEuPathDB; VectorBase:ASIS006085; -.
DR OMA; WIFDEMK; -.
DR Proteomes; UP000030765; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 4.
DR InterPro; IPR011249; Metalloenz_LuxS/M16.
DR InterPro; IPR011765; Pept_M16_N.
DR InterPro; IPR001431; Pept_M16_Zn_BS.
DR InterPro; IPR007863; Peptidase_M16_C.
DR InterPro; IPR032632; Peptidase_M16_M.
DR PANTHER; PTHR43690:SF18; INSULIN-DEGRADING ENZYME-RELATED; 1.
DR PANTHER; PTHR43690; NARDILYSIN; 1.
DR Pfam; PF00675; Peptidase_M16; 1.
DR Pfam; PF05193; Peptidase_M16_C; 2.
DR Pfam; PF16187; Peptidase_M16_M; 1.
DR SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 4.
DR PROSITE; PS00143; INSULINASE; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000030765};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 41..176
FT /note="Peptidase M16 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00675"
FT DOMAIN 204..382
FT /note="Peptidase M16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05193"
FT DOMAIN 388..668
FT /note="Peptidase M16 middle/third"
FT /evidence="ECO:0000259|Pfam:PF16187"
FT DOMAIN 673..855
FT /note="Peptidase M16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05193"
SQ SEQUENCE 999 AA; 114641 MW; 07EAB35C911B4113 CRC64;
MTATAIQSCN RTSFERSNDI TKSAQDNREY RGLKLSNGMK IILVSDPTTD RSAAALSVAV
GHLCDPTDLP GLAHLCEHML FLGTKKYPLE HEYTTFLKEH GGSSNAATFS DMTKYYFDVI
PDKLEDALDR FSQFFIAPLF NEDVTDREIN AVNSEHEKNL SQDMWRVKQV NKSLCKASHA
YNRFGSGSKE TLYENPRQNN INVRNELMKF HNKWYSPNIM SLAVFGKESL DDLERIVIQM
FSQIENKNVT APSWPDMPYD DDQLGTKTYI IPVKDTRSLT ISFQLEDLEQ YYKAGPEHYV
SHLVGHEGKG SILSELKARG WCNKLISGYS NLGRGFGCFE IMVDLTEDGF NHIDDTAKII
FQYLNMLRLQ GPQKWIFEEY RNLCDMLFRF KDKESSLSVV TNVVTAMHVF PLEDVLTAHC
LISEWRPDLI EDLMSKLTPS KARIIIVGQQ CSSLTNAEER WYGTKYGVHK IEASTLEYWS
SADLNTNLQL PEPNPFIPTN FDLLPTDSDV DTFPTVIYDT PMIRLWFKQD VEFLKPKTMM
NFDFNSPLVY SDPLNCNMTR LFVQLLKDHL NEFLFEADLA GLGFGVGNTT SGISLSIGGY
SHKQHILLEK VLDSMFNFKI DERRFEVFKE QYIRSLKNYQ TEQPYQHAIY YLALLLTELA
WTRQELLDSM QLLTMERLQA FVDQLLSRMH VEGFIYGNVN KDKAMTMMRM VENKMKTTDS
EVVPLLARQL LQKREYKLGN GESCLFEATN EFHKSSCTEL YLQCGPQEPH STYVDILSQM
LSEACYTQLR TKEQLGYLVF CGSRKANGIS GIRIIVQSAH HPAYVEERIE NFFNNMLDYL
EKMPDDEFNR HKEALVALFL EKPKRLASQF SIFLQEISLR QYHFNRAQVE AAKLRTLTKQ
QVIDYYKEYI ILGGPSRSTL SVHVLSTGEG GAGANGIKTA ELEAAEEIFD DSIASHRKEI
TKKEFVRVTD LASFKSSRSL YPLVQPYLEI LPKGGRCKL
//
