ID A0A084WDP8_ANOSI Unreviewed; 637 AA.
AC A0A084WDP8;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=Protein inhibitor of activated STAT {ECO:0000313|EMBL:KFB48342.1, ECO:0000313|EnsemblMetazoa:ASIC016489-PA};
GN ORFNames=ZHAS_00016489 {ECO:0000313|EMBL:KFB48342.1};
OS Anopheles sinensis (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=74873 {ECO:0000313|EMBL:KFB48342.1};
RN [1] {ECO:0000313|EMBL:KFB48342.1, ECO:0000313|Proteomes:UP000030765}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24438588; DOI=10.1186/1471-2164-15-42;
RA Zhou D., Zhang D., Ding G., Shi L., Hou Q., Ye Y., Xu Y., Zhou H.,
RA Xiong C., Li S., Yu J., Hong S., Yu X., Zou P., Chen C., Chang X., Wang W.,
RA Lv Y., Sun Y., Ma L., Shen B., Zhu C.;
RT "Genome sequence of Anopheles sinensis provides insight into genetics basis
RT of mosquito competence for malaria parasites.";
RL BMC Genomics 15:42-42(2014).
RN [2] {ECO:0000313|EnsemblMetazoa:ASIC016489-PA}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein sumoylation.
CC {ECO:0000256|ARBA:ARBA00004718}.
CC -!- SIMILARITY: Belongs to the PIAS family.
CC {ECO:0000256|ARBA:ARBA00005383}.
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DR EMBL; ATLV01023052; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KE525340; KFB48342.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A084WDP8; -.
DR STRING; 74873.A0A084WDP8; -.
DR EnsemblMetazoa; ASIC016489-RA; ASIC016489-PA; ASIC016489.
DR VEuPathDB; VectorBase:ASIC016489; -.
DR VEuPathDB; VectorBase:ASIS004788; -.
DR OMA; CWPASTQ; -.
DR UniPathway; UPA00886; -.
DR Proteomes; UP000030765; Unassembled WGS sequence.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0016925; P:protein sumoylation; IEA:UniProtKB-UniPathway.
DR GO; GO:0060255; P:regulation of macromolecule metabolic process; IEA:UniProt.
DR CDD; cd16790; SP-RING_PIAS; 1.
DR Gene3D; 2.60.120.780; PINIT domain; 1.
DR Gene3D; 1.10.720.30; SAP domain; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR023321; PINIT.
DR InterPro; IPR038654; PINIT_sf.
DR InterPro; IPR003034; SAP_dom.
DR InterPro; IPR036361; SAP_dom_sf.
DR InterPro; IPR004181; Znf_MIZ.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR10782:SF97; SUPPRESSOR OF VARIEGATION 2-10, ISOFORM I; 1.
DR PANTHER; PTHR10782; ZINC FINGER MIZ DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF14324; PINIT; 1.
DR Pfam; PF02891; zf-MIZ; 1.
DR SMART; SM00513; SAP; 1.
DR SUPFAM; SSF68906; SAP domain; 1.
DR PROSITE; PS51466; PINIT; 1.
DR PROSITE; PS50800; SAP; 1.
DR PROSITE; PS51044; ZF_SP_RING; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000030765};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00452}.
FT DOMAIN 14..48
FT /note="SAP"
FT /evidence="ECO:0000259|PROSITE:PS50800"
FT DOMAIN 162..328
FT /note="PINIT"
FT /evidence="ECO:0000259|PROSITE:PS51466"
FT DOMAIN 360..441
FT /note="SP-RING-type"
FT /evidence="ECO:0000259|PROSITE:PS51044"
FT REGION 500..609
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 52..79
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 500..518
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 533..583
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 591..609
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 637 AA; 70010 MW; 2FCCEE102FB178CF CRC64;
MIRTLMLLSF QDLVHQLRVS DLQQLLAENN ISRSGRKSEL IERVLILLRQ NISVLRHKVR
ELHRKAQQEA KELAAAVNNV STGSDQLPAS VLQSVQNNPR AVQTLLASGA AHLNATTNGT
LVNNNIHGIS NSRTVAGMYQ QQYNNAVTND NRVNTVHGNG LEIPPYNFPV HNDVKLKKLA
FFDVLATLLK PSTLMPSNNT QRNQEGSFYF HLTPQQAEDI ALHRDIRNPT KVEHVIQVQL
RFCLLETSCE QEDYFPPNIV VKVNNKLCTL PNPIPTNKPG VDPKRPPRPV NITPHVKISP
LLANHISVSW NTEYNRCYAA ACYLVRKLCS TTLLQRMKQK GVKAADFTRA LIKEKLNEDA
DSEIATTMLK VSLICPLGKM RMTTPCRAST CLHLQCFDAS LYLQMNERKP TWNCPVCDKP
AVYDNLVIDG YFQEVLASTK LSPEDTEIQL HKDGSWSTHI KQSESLDDSV GKVVQKVEVI
SDDIEVITTD PPKHSIVAQT SVISTNEPSS TSGETVDLTL SDSDDDGPKG KPRNNRSTSS
SNNPTSSSSS AAHAGATSAG NGAVTRSKLN EDPSSSVISL DSPSPPSTPN PSQNGSNNDV
SSTTTPSLAY HALNQQQQSA LGSDQLNFQF NPLALPR
//
