ID A0A084WE10_ANOSI Unreviewed; 900 AA.
AC A0A084WE10;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 24-JAN-2024, entry version 38.
DE RecName: Full=Origin recognition complex subunit 1 {ECO:0000256|ARBA:ARBA00019081, ECO:0000256|RuleBase:RU365058};
GN ORFNames=ZHAS_00016437 {ECO:0000313|EMBL:KFB48454.1};
OS Anopheles sinensis (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=74873 {ECO:0000313|EMBL:KFB48454.1};
RN [1] {ECO:0000313|EMBL:KFB48454.1, ECO:0000313|Proteomes:UP000030765}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24438588; DOI=10.1186/1471-2164-15-42;
RA Zhou D., Zhang D., Ding G., Shi L., Hou Q., Ye Y., Xu Y., Zhou H.,
RA Xiong C., Li S., Yu J., Hong S., Yu X., Zou P., Chen C., Chang X., Wang W.,
RA Lv Y., Sun Y., Ma L., Shen B., Zhu C.;
RT "Genome sequence of Anopheles sinensis provides insight into genetics basis
RT of mosquito competence for malaria parasites.";
RL BMC Genomics 15:42-42(2014).
RN [2] {ECO:0000313|EnsemblMetazoa:ASIC016437-PA}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- FUNCTION: Component of the origin recognition complex (ORC) that binds
CC origins of replication. DNA-binding is ATP-dependent, however specific
CC DNA sequences that define origins of replication have not been
CC identified so far. ORC is required to assemble the pre-replication
CC complex necessary to initiate DNA replication.
CC {ECO:0000256|RuleBase:RU365058}.
CC -!- SUBUNIT: ORC is composed of six subunits.
CC {ECO:0000256|RuleBase:RU365058}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU365058}.
CC -!- SIMILARITY: Belongs to the ORC1 family. {ECO:0000256|ARBA:ARBA00008398,
CC ECO:0000256|RuleBase:RU365058}.
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DR EMBL; ATLV01023101; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KE525340; KFB48454.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A084WE10; -.
DR STRING; 74873.A0A084WE10; -.
DR EnsemblMetazoa; ASIC016437-RA; ASIC016437-PA; ASIC016437.
DR VEuPathDB; VectorBase:ASIC016437; -.
DR VEuPathDB; VectorBase:ASIS022003; -.
DR OMA; KTPSNDM; -.
DR Proteomes; UP000030765; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003682; F:chromatin binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd08768; Cdc6_C; 1.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 2.30.30.490; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR041083; AAA_lid_10.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR001025; BAH_dom.
DR InterPro; IPR043151; BAH_sf.
DR InterPro; IPR015163; Cdc6_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10763; CELL DIVISION CONTROL PROTEIN 6-RELATED; 1.
DR PANTHER; PTHR10763:SF23; ORIGIN RECOGNITION COMPLEX SUBUNIT 1; 1.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF17872; AAA_lid_10; 1.
DR Pfam; PF09079; Cdc6_C; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00439; BAH; 1.
DR SMART; SM01074; Cdc6_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51038; BAH; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|RuleBase:RU365058};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705,
KW ECO:0000256|RuleBase:RU365058};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU365058};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Nucleotide-binding {ECO:0000256|RuleBase:RU365058};
KW Nucleus {ECO:0000256|RuleBase:RU365058};
KW Reference proteome {ECO:0000313|Proteomes:UP000030765}.
FT DOMAIN 45..183
FT /note="BAH"
FT /evidence="ECO:0000259|PROSITE:PS51038"
FT REGION 336..405
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 431..496
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 379..405
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 431..459
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 900 AA; 100332 MW; 2BE8D796B6BF9D41 CRC64;
MKTKSFNNNT TSCPITWVGK QYNPAITAVK HRSAIFYSKC IFGAMTLEVG NCVLVSNIDS
AEPDSVDGCD VARIVHMYEV FNVPCTKMDP CRAIVQWYSR PSGLPKSITD DENYSFDPRE
VVEDSRFNPD ISIETIFGAC RLEKVSTQAN LDEILPRTST ARCPMFFVRY KLGKSSARKW
HLEPLIPTFD ARTPSRRRTM VDKSNQPMVL GTPRTPKLKL TRTKSVENIA ILSENQREKI
LEDRWAVKLI DIKDSPMDLI TNALSGVDIS DDEQNVSPRK QSKVLGEKRS SMNFKRNLDA
SFHVADEGTD DDCLNYSIVK DNASNAANMK IKLRLSENQK NPETPRSLRK RVTSGSIPVE
HVSPPKCRKS LLPSEVEPVG TPTASTRRKS ILKTPSTNTK CQESVATPKR NIQLSNIVEE
CANGRRVSRV LELTPKKTQP DRAADDEPIT PKRRGRPPSI AREQPVVLVD EEPKTPKRRG
RPSSAGPSLS TPKSASKMKL IRSGAIKPNI HSRDAPVEDG ANDLAIARER LHVSSIPTSL
PCREKEFDEI YNFLESKIYD GCGGCMYVSG VPGTGKTATT TAVIRSLQQL SDDEEIPKFD
YIEINGMRLT EPRQAYVHIY RQLTGKTLAW EQAYNLLDKR FTTKAPRRVT TVLLVDELDI
LCNRRQDVVY NLLNWPTLST AQLIVVTIAN TMDLPERLLM GKIASRLGLT RLTFQPYNFK
QLQEIVMARL TGTSAFNSDA VQLVARKVAA VSGDARRALD ICRRATELAD DQSQKTNQEV
TVSMVHVQQA LAEMIASAKV QTIRSCSLME QLFLQAVTAE VTRTGIEECN FLGVYAQFEA
LAAFSGITVP NTGRAMAICA RLGASRLLIC ETGRNDIYQK ILLNVSTDDV HYALQASKLL
//
