ID A0A084WFW9_ANOSI Unreviewed; 1147 AA.
AC A0A084WFW9;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=Protein smoothened {ECO:0000256|ARBA:ARBA00035037};
GN ORFNames=ZHAS_00017265 {ECO:0000313|EMBL:KFB49113.1};
OS Anopheles sinensis (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=74873 {ECO:0000313|EMBL:KFB49113.1};
RN [1] {ECO:0000313|EMBL:KFB49113.1, ECO:0000313|Proteomes:UP000030765}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24438588; DOI=10.1186/1471-2164-15-42;
RA Zhou D., Zhang D., Ding G., Shi L., Hou Q., Ye Y., Xu Y., Zhou H.,
RA Xiong C., Li S., Yu J., Hong S., Yu X., Zou P., Chen C., Chang X., Wang W.,
RA Lv Y., Sun Y., Ma L., Shen B., Zhu C.;
RT "Genome sequence of Anopheles sinensis provides insight into genetics basis
RT of mosquito competence for malaria parasites.";
RL BMC Genomics 15:42-42(2014).
RN [2] {ECO:0000313|EnsemblMetazoa:ASIC017265-PA}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Cell
CC projection, cilium {ECO:0000256|ARBA:ARBA00004138}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor Fz/Smo family.
CC {ECO:0000256|ARBA:ARBA00008077}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00090}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; ATLV01023407; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KE525343; KFB49113.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A084WFW9; -.
DR STRING; 74873.A0A084WFW9; -.
DR EnsemblMetazoa; ASIC017265-RA; ASIC017265-PA; ASIC017265.
DR VEuPathDB; VectorBase:ASIC017265; -.
DR VEuPathDB; VectorBase:ASIS017172; -.
DR OMA; HGPRKNS; -.
DR Proteomes; UP000030765; Unassembled WGS sequence.
DR GO; GO:0005929; C:cilium; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR GO; GO:0009888; P:tissue development; IEA:UniProt.
DR CDD; cd15030; 7tmF_SMO_homolog; 1.
DR Gene3D; 1.10.2000.10; Frizzled cysteine-rich domain; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR015526; Frizzled/SFRP.
DR InterPro; IPR000539; Frizzled/Smoothened_7TM.
DR InterPro; IPR020067; Frizzled_dom.
DR InterPro; IPR036790; Frizzled_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR035683; SMO_7TM.
DR PANTHER; PTHR11309; FRIZZLED; 1.
DR PANTHER; PTHR11309:SF35; SMOOTHENED HOMOLOG; 1.
DR Pfam; PF01534; Frizzled; 1.
DR Pfam; PF01392; Fz; 1.
DR PRINTS; PR00489; FRIZZLED.
DR SMART; SM00063; FRI; 1.
DR SMART; SM01330; Frizzled; 1.
DR SUPFAM; SSF63501; Frizzled cysteine-rich domain; 1.
DR PROSITE; PS50038; FZ; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000030765};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..1147
FT /note="Protein smoothened"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5001784891"
FT TRANSMEM 245..266
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 278..295
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 327..351
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 371..390
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 416..439
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 460..480
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 73..192
FT /note="FZ"
FT /evidence="ECO:0000259|PROSITE:PS50038"
FT DOMAIN 242..520
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 693..737
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 840..985
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1120..1139
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 703..719
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 720..735
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 869..884
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 939..955
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 956..972
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1147 AA; 127340 MW; CD7FA4A487FF1A08 CRC64;
MAVLKTIFFL VVLSATIIEG KEFIPTTNLI TPEAPRPMLE PINGTRNYRM HGKKGKDDKT
WFDGREMRYI YCVRPGKCEP IKHKSCLGST LPYSSFSLDL TDSYSQEETH HKLYQYNALR
HVPKCWAVIQ PFLCAVFMPK CEKINGQEMV YLPSLEMCKI TLEPCRILYN TSYFPEFLKC
NETLYPSKCN NDVREEMKFN ATGQCLKPLV AADLPANYYK DIDGCGLQCK DPLYTDHEHR
QIHKLIAWGA GICLTFNFFT LATFAIDWHN ANKYPALVIF YINFCFAISC LGWLAQFTPG
GREDIVCRKD GTLRTSEPSA GENLSCIVVF ILVYYFLIAA MVWFVIFTYV WHMSFKAIGK
IQDRIDKKGS YFHLIAWSLP LVLTITIMAL SEIDGNGTVG ICFVGYLNPP IRGGFLLAPV
ICVLLIGGYF LGRGLLTLIR LRISSKEIIS ARASRKIHQT IVRMGICTAF TFVFIVATVF
CHVHEFRHSA AWATALRNYI VCQISSTYTD DVMTGSCRIE QRPSVAILQL HLICLFASGI
VMSSWVWTNS TLESWARYFR RRFGTDVDEP VKLQKHKVIA QAFAKRKEFQ NQGRLSISFH
NSHTDPVGLK FDINSAIGSH DFSSTWANNL PRFVNRRCAL TGAATSSSHD PRKNSVDSEI
SFSVRHVSVE SRRNSIDSQV SVKIAEVKTK VASRSSRGPV VVGGGKHHHH AHKTRQSRRR
HDFASAGRRY SRKESSTSVE SQIITAALQK TGSVSAGAGR HSASTAAGSF GGNMQRRTGI
GALDADQIND LISNGKLLLP FLQGQGLTTS EDDNVSVGSF KLQDSKFDII LKQIDGIGSS
GAGVRSDDAI GTSAVTGTTS GCRIEEYRSS DDDDDDDDDD DDDRRTENEP LRGRNGTLRP
ITSGRDDTVQ ARVADAASGG DGMRSSKEGG RVSKGSITKG GRNRKTGGSS RPGTLRKSQH
HNHHRTHSAH RKDREKKEKA REREKELELI ERAGGGGTNN HKQSASKACA TNQASADIEM
YDFNHDSSFT SYCSELLTPL NINSSYSGVS LAKTNSRNSK RSCDVGIQTN AHEIATQTMS
SFEFNEKALK NEENEDIYTE NHQLLPKLAP AMIVVGGGGG VGRKQRDAND SGMSDAEKLK
MLLLPSK
//
