ID   A0A084WQ40_ANOSI        Unreviewed;       886 AA.
AC   A0A084WQ40;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   27-MAR-2024, entry version 32.
DE   SubName: Full=Alpha-carbonic anhydrase domain-containing protein {ECO:0000313|EnsemblMetazoa:ASIC020540-PA};
GN   ORFNames=ZHAS_00020540 {ECO:0000313|EMBL:KFB52334.1};
OS   Anopheles sinensis (Mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=74873 {ECO:0000313|EMBL:KFB52334.1};
RN   [1] {ECO:0000313|EMBL:KFB52334.1, ECO:0000313|Proteomes:UP000030765}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=24438588; DOI=10.1186/1471-2164-15-42;
RA   Zhou D., Zhang D., Ding G., Shi L., Hou Q., Ye Y., Xu Y., Zhou H.,
RA   Xiong C., Li S., Yu J., Hong S., Yu X., Zou P., Chen C., Chang X., Wang W.,
RA   Lv Y., Sun Y., Ma L., Shen B., Zhu C.;
RT   "Genome sequence of Anopheles sinensis provides insight into genetics basis
RT   of mosquito competence for malaria parasites.";
RL   BMC Genomics 15:42-42(2014).
RN   [2] {ECO:0000313|EnsemblMetazoa:ASIC020540-PA}
RP   IDENTIFICATION.
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
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DR   EMBL; ATLV01025177; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KE525371; KFB52334.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A084WQ40; -.
DR   STRING; 74873.A0A084WQ40; -.
DR   EnsemblMetazoa; ASIC020540-RA; ASIC020540-PA; ASIC020540.
DR   VEuPathDB; VectorBase:ASIC020540; -.
DR   VEuPathDB; VectorBase:ASIS010875; -.
DR   VEuPathDB; VectorBase:ASIS019084; -.
DR   OMA; HWNQSKY; -.
DR   Proteomes; UP000030765; Unassembled WGS sequence.
DR   GO; GO:0004089; F:carbonate dehydratase activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd00326; alpha_CA; 1.
DR   CDD; cd13394; Syo1_like; 1.
DR   Gene3D; 3.10.200.10; Alpha carbonic anhydrase; 1.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR000225; Armadillo.
DR   InterPro; IPR001148; CA_dom.
DR   InterPro; IPR036398; CA_dom_sf.
DR   InterPro; IPR018338; Carbonic_anhydrase_a-class_CS.
DR   PANTHER; PTHR13347:SF1; HEAT REPEAT-CONTAINING PROTEIN 3; 1.
DR   PANTHER; PTHR13347; UNCHARACTERIZED; 1.
DR   Pfam; PF00194; Carb_anhydrase; 1.
DR   SMART; SM00185; ARM; 3.
DR   SMART; SM01057; Carb_anhydrase; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   SUPFAM; SSF51069; Carbonic anhydrase; 1.
DR   PROSITE; PS00162; ALPHA_CA_1; 1.
DR   PROSITE; PS51144; ALPHA_CA_2; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000030765}.
FT   DOMAIN          1..256
FT                   /note="Alpha-carbonic anhydrase"
FT                   /evidence="ECO:0000259|PROSITE:PS51144"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          587..608
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        10..24
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   886 AA;  98582 MW;  292614D5143F1DF1 CRC64;
     MFPQARGQRQ SPVDIVTSKT QNSGDLQENP LKWTYVPENT RSLVNPGYCW RVDVNGKGSL
     LTGGPLQQEE FILEQFHCHW GCSDSRGSEH TVDGESFAGE LHLVHWNQSK YKSFAEAAGH
     PDGLAVLGVF LKVGKPHPEL DIIARLLPFI THKGDRVTLN KPLDPARLLP EGKAYWTYLG
     SLTTPPCSES VTWILFKEPI EVSHEQLELF REMRCYDAAE ECPCDATINK QFEYGKVINN
     YRPPLELGNR QLREQGLAGS AKSGTPIDAI VEQIESSVTE EKICGLQSLA TICQGEVNLA
     EIVASNIIRI AASLLVHPDS SVRHATAGAL RNLSVGSVEL CEFMVDQDVL TPLLALLNRY
     TSATQWKPTF DRSMQDQMDE HSDTFLQGVN LLWNLCESTS DALTAFNQAQ LLQPFVTFLN
     CNVYGKEIAI AVAQCLLVVS EENTSSWRVL ANHGLELSTL LALDGTDNAT MMLRVLAAGI
     ICNVPVLLSS HMSQILQTIA KTMEANHRVA LGNLTSILPL TAQKEVVDLE VTDDVQIDDE
     TEAESHQRRR KADLPSDGEL EVRNVGWMLQ AQRIAAEILT NICSTDDDDW QSEGNENVDN
     NGAGSDAESV YDYDTNELNG SVENTDKVPV EVLEAIKSLA LVEKLWQKAQ PMAENVHQIL
     AESEKGTLKK LDSLRISAML CLHNLCNNIT TEDLGGPAAV YNVWIDLGQQ VFQGQGNVKL
     LEASTSLMRA TLEHLRKSPE LFKQMTESDL QLMLNGVVGC EDPEIRANWL RMLGMLGCLL
     PEPLVKLIID FVLNTCANET DVWVLAEALD SMMDIFADND WYAIVHEVGM VAKCKQLDRV
     MREKLKRDKR QLGDRFPAVS TVRTNLGRFC KYLETEMKNY KPNMES
//