ID A0A084WUQ4_ANOSI Unreviewed; 638 AA.
AC A0A084WUQ4;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Sodium-dependent nutrient amino acid transporter 1 {ECO:0000256|ARBA:ARBA00040215};
GN ORFNames=ZHAS_00022195 {ECO:0000313|EMBL:KFB53948.1};
OS Anopheles sinensis (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=74873 {ECO:0000313|EMBL:KFB53948.1};
RN [1] {ECO:0000313|EMBL:KFB53948.1, ECO:0000313|Proteomes:UP000030765}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24438588; DOI=10.1186/1471-2164-15-42;
RA Zhou D., Zhang D., Ding G., Shi L., Hou Q., Ye Y., Xu Y., Zhou H.,
RA Xiong C., Li S., Yu J., Hong S., Yu X., Zou P., Chen C., Chang X., Wang W.,
RA Lv Y., Sun Y., Ma L., Shen B., Zhu C.;
RT "Genome sequence of Anopheles sinensis provides insight into genetics basis
RT of mosquito competence for malaria parasites.";
RL BMC Genomics 15:42-42(2014).
RN [2] {ECO:0000313|EnsemblMetazoa:ASIC022195-PA}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- FUNCTION: Unusual broad substrate spectrum amino acid:sodium
CC cotransporter that promotes absorption of the D isomers of essential
CC amino acids. Neutral amino acids are the preferred substrates,
CC especially methionine and phenylalanine.
CC {ECO:0000256|ARBA:ARBA00037785}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the sodium:neurotransmitter symporter (SNF) (TC
CC 2.A.22) family. {ECO:0000256|ARBA:ARBA00006459}.
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DR EMBL; ATLV01027104; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KE525423; KFB53948.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A084WUQ4; -.
DR STRING; 74873.A0A084WUQ4; -.
DR EnsemblMetazoa; ASIC022195-RA; ASIC022195-PA; ASIC022195.
DR VEuPathDB; VectorBase:ASIC022195; -.
DR VEuPathDB; VectorBase:ASIS005967; -.
DR OMA; ITFCWIY; -.
DR Proteomes; UP000030765; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR GO; GO:0006865; P:amino acid transport; IEA:UniProtKB-KW.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR CDD; cd10324; SLC6sbd; 1.
DR InterPro; IPR000175; Na/ntran_symport.
DR InterPro; IPR037272; SNS_sf.
DR PANTHER; PTHR11616:SF241; SODIUM-DEPENDENT NUTRIENT AMINO ACID TRANSPORTER 1-RELATED; 1.
DR PANTHER; PTHR11616; SODIUM/CHLORIDE DEPENDENT TRANSPORTER; 1.
DR Pfam; PF00209; SNF; 1.
DR PRINTS; PR00176; NANEUSMPORT.
DR SUPFAM; SSF161070; SNF-like; 1.
DR PROSITE; PS00754; NA_NEUROTRAN_SYMP_2; 1.
DR PROSITE; PS50267; NA_NEUROTRAN_SYMP_3; 1.
PE 3: Inferred from homology;
KW Amino-acid transport {ECO:0000256|ARBA:ARBA00022970};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000030765};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Symport {ECO:0000256|ARBA:ARBA00022847};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 75..92
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 104..122
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 153..174
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 237..255
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 267..290
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 310..334
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 346..367
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 410..438
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 450..468
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 480..500
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 520..541
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 556..578
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 638 AA; 70657 MW; 2E0D58282D56C329 CRC64;
MVNECNLNDV LVRPNTYDPE ADDDKTTTTT WSSGPAAAML GQFRDGATTR DSSMDVSTDG
SGEVRRAKWG RSIEFLLSCV ALSVGFGNVW RFPQVAMENG GGAFMIPYLI ILFLVGRPMY
YLEMVMGQFS SRGCVKVFDL SPLMRGVGVG QTLIMALILG FYSAVLSISV RYLIASFSST
LPWARCSSDW TNCVNSESLT RVFNSTTHRP SAEFYFNEDI IHSESIKESG VLGWPDYNLA
LCLLFCWICI TVILIRGIRS SGKAAYFLAI FPYVILLVLL VQVCSLEGAW DGISFLLKPQ
WEKLLDVKVW QAAVTQCFFS LTISLGAVIV FSSYNNFSNN IYRDSMIISW LDTFTSLMSG
FIVFGILGNI ASITGNTVET LKETLKLGGP GLTFITYPDA IAKLEAGRNV FAVLFFLMFF
LLGLGSNTGI VTTIVSGVKD RYPQLTDWKV VSVVSIYGFS TGLIYITPGG FDVLGVVNDY
GVELTVLTLV ILEIVTFCWV YGVNRICHDI KFMLDISTGI FWRVCWGFVT FTIIFTIWIF
SMKNFTAHDV PDGLNALGWC LFALVVVQVP LWAVYAVSKR TETGLAKKII AASHPTPDWG
PESPSTQMQY KTEVRKRAEE KLASGKSIGT RLCPIFSE
//
