ID A0A085G3C2_9GAMM Unreviewed; 398 AA.
AC A0A085G3C2;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE SubName: Full=HemY family protein {ECO:0000313|EMBL:KFC78217.1};
GN ORFNames=GEAM_3826 {ECO:0000313|EMBL:KFC78217.1};
OS Ewingella americana ATCC 33852.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Yersiniaceae; Ewingella.
OX NCBI_TaxID=910964 {ECO:0000313|EMBL:KFC78217.1, ECO:0000313|Proteomes:UP000028640};
RN [1] {ECO:0000313|EMBL:KFC78217.1, ECO:0000313|Proteomes:UP000028640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33852 {ECO:0000313|EMBL:KFC78217.1,
RC ECO:0000313|Proteomes:UP000028640};
RA Plunkett G.III., Neeno-Eckwall E.C., Glasner J.D., Perna N.T.;
RT "ATOL: Assembling a taxonomically balanced genome-scale reconstruction of
RT the evolutionary history of the Enterobacteriaceae.";
RL Submitted (MAY-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in a late step of protoheme IX synthesis.
CC {ECO:0000256|ARBA:ARBA00002962}.
CC -!- PATHWAY: Porphyrin-containing compound metabolism; protoheme
CC biosynthesis. {ECO:0000256|ARBA:ARBA00004744}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004429}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KFC78217.1}.
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DR EMBL; JMPJ01000069; KFC78217.1; -; Genomic_DNA.
DR RefSeq; WP_034794773.1; NZ_JMPJ01000069.1.
DR AlphaFoldDB; A0A085G3C2; -.
DR STRING; 910964.GEAM_3826; -.
DR GeneID; 78383084; -.
DR eggNOG; COG3071; Bacteria.
DR OrthoDB; 7067577at2; -.
DR UniPathway; UPA00252; -.
DR Proteomes; UP000028640; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0042168; P:heme metabolic process; IEA:InterPro.
DR GO; GO:0006779; P:porphyrin-containing compound biosynthetic process; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR005254; Heme_biosyn_assoc_TPR_pro.
DR InterPro; IPR010817; HemY_N.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR013105; TPR_2.
DR InterPro; IPR019734; TPR_repeat.
DR NCBIfam; TIGR00540; TPR_hemY_coli; 1.
DR Pfam; PF07219; HemY_N; 1.
DR Pfam; PF07719; TPR_2; 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS50005; TPR; 1.
PE 4: Predicted;
KW Cell inner membrane {ECO:0000256|ARBA:ARBA00022519};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Porphyrin biosynthesis {ECO:0000256|ARBA:ARBA00023244};
KW Reference proteome {ECO:0000313|Proteomes:UP000028640};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 41..62
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 26..132
FT /note="HemY N-terminal"
FT /evidence="ECO:0000259|Pfam:PF07219"
FT REPEAT 328..361
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
SQ SEQUENCE 398 AA; 44979 MW; 5144E1F67A7978A7 CRC64;
MLKVLVLFLI IIAGIVVGPM LAGHQGYVLI QTDNYNVETS VTGLVIMFVV LMLVLFFIEW
ILRRVFRTGA RTRGWFAGRK SSKARKQTQA AMLKLAEGDH RQMEKLLARN ADHADQPVVN
YLLAAEAAQQ RGDDIRTNQY LERAAEIADI DQMPVDITRV RIQLAQGEIH AARHGVDRLI
GQSPRHPEIL RLAEQAYLRT GAYASLLEIL PSMAKAGVHD DEELRVLQEQ AYIGLMNQIM
AEEGSDGLKR WWKDQNRKTR HEVALQVAMA AHLIECNDQD LAQEVILDGI KRQYDERLVA
MMPKLRSGNP EQLEKALRQI IKQNGSTALL SSTLGQLLMK HGEWAQAAES FREALKQRPD
AYDYAWLADA LDKLHKPAEA AEMRHKGLML TLNNSQEQ
//
