ID A0A085G4D5_9ENTR Unreviewed; 390 AA.
AC A0A085G4D5;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Multidrug resistance protein A {ECO:0000313|EMBL:KFC78580.1};
GN ORFNames=GBAG_3209 {ECO:0000313|EMBL:KFC78580.1};
OS Buttiauxella agrestis ATCC 33320.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Buttiauxella.
OX NCBI_TaxID=1006004 {ECO:0000313|EMBL:KFC78580.1, ECO:0000313|Proteomes:UP000028653};
RN [1] {ECO:0000313|EMBL:KFC78580.1, ECO:0000313|Proteomes:UP000028653}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33320 {ECO:0000313|EMBL:KFC78580.1,
RC ECO:0000313|Proteomes:UP000028653};
RA Plunkett G.III., Neeno-Eckwall E.C., Glasner J.D., Perna N.T.;
RT "ATOL: Assembling a taxonomically balanced genome-scale reconstruction of
RT the evolutionary history of the Enterobacteriaceae.";
RL Submitted (MAY-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC family. {ECO:0000256|ARBA:ARBA00009477}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KFC78580.1}.
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DR EMBL; JMPI01000056; KFC78580.1; -; Genomic_DNA.
DR RefSeq; WP_034497911.1; NZ_JMPI01000056.1.
DR AlphaFoldDB; A0A085G4D5; -.
DR STRING; 1006004.GBAG_3209; -.
DR eggNOG; COG1566; Bacteria.
DR OrthoDB; 9811754at2; -.
DR Proteomes; UP000028653; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR GO; GO:1990961; P:xenobiotic detoxification by transmembrane export across the plasma membrane; IEA:InterPro.
DR Gene3D; 2.40.30.170; -; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 1.10.287.470; Helix hairpin bin; 1.
DR InterPro; IPR043602; CusB_dom_1.
DR InterPro; IPR032317; HlyD_D23.
DR InterPro; IPR005694; MFP_proteobact.
DR NCBIfam; TIGR00998; 8a0101; 1.
DR PANTHER; PTHR30386; MEMBRANE FUSION SUBUNIT OF EMRAB-TOLC MULTIDRUG EFFLUX PUMP; 1.
DR PANTHER; PTHR30386:SF19; MULTIDRUG EXPORT PROTEIN EMRA-RELATED; 1.
DR Pfam; PF00529; CusB_dom_1; 1.
DR Pfam; PF16576; HlyD_D23; 1.
DR SUPFAM; SSF111369; HlyD-like secretion proteins; 3.
PE 3: Inferred from homology;
KW Cell inner membrane {ECO:0000256|ARBA:ARBA00022519};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022519};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000028653};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 23..44
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 36..346
FT /note="Cation efflux system protein CusB"
FT /evidence="ECO:0000259|Pfam:PF00529"
FT DOMAIN 61..289
FT /note="RND efflux pump membrane fusion protein barrel-
FT sandwich"
FT /evidence="ECO:0000259|Pfam:PF16576"
SQ SEQUENCE 390 AA; 42624 MW; F344D0E51C3FB15A CRC64;
MSAHAETQTP QQPGNKKGKR KGALLLLTLL FVIIAVAYGI YWFLVLRHYE NTDDAYVAGN
QVQIMSQVSG SVTKVWADNT DFVKQGDVLV TLDQADAEQA FEQAQTVLAS SVRQTRQLMI
NSKQYQANIE LQKTSLAQAQ SDLNRRVPLG NANLIGREEL QHARDAVASA QAQLDVAVQQ
YNANQAMILG TKLEEQPSVK QAAAELRNAW MALQRTKIVS PMTGYVSRRV VQVGAQISPT
TPLMAIVPAS GLWVDANFKE TQLAHMRIGQ PATVVSDIYG DKVEYTGKVV GLDMGTGSAF
SLLPAQNATG NWIKVVQRLP VRIELDAKQL EQHPLRIGLS TLVTVDTSNR EGSMLANTTR
HSPVYESNAR ELNLAPANEL INNIIQANAG
//
