ID A0A085GJF7_9GAMM Unreviewed; 753 AA.
AC A0A085GJF7;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE SubName: Full=Metallo-beta-lactamase superfamily hydrolase {ECO:0000313|EMBL:KFC83852.1};
DE EC=3.-.-.- {ECO:0000313|EMBL:KFC83852.1};
GN ORFNames=GEAM_1035 {ECO:0000313|EMBL:KFC83852.1};
OS Ewingella americana ATCC 33852.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Yersiniaceae; Ewingella.
OX NCBI_TaxID=910964 {ECO:0000313|EMBL:KFC83852.1, ECO:0000313|Proteomes:UP000028640};
RN [1] {ECO:0000313|EMBL:KFC83852.1, ECO:0000313|Proteomes:UP000028640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33852 {ECO:0000313|EMBL:KFC83852.1,
RC ECO:0000313|Proteomes:UP000028640};
RA Plunkett G.III., Neeno-Eckwall E.C., Glasner J.D., Perna N.T.;
RT "ATOL: Assembling a taxonomically balanced genome-scale reconstruction of
RT the evolutionary history of the Enterobacteriaceae.";
RL Submitted (MAY-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KFC83852.1}.
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DR EMBL; JMPJ01000033; KFC83852.1; -; Genomic_DNA.
DR RefSeq; WP_072009866.1; NZ_JMPJ01000033.1.
DR AlphaFoldDB; A0A085GJF7; -.
DR STRING; 910964.GEAM_1035; -.
DR GeneID; 78379377; -.
DR eggNOG; COG0658; Bacteria.
DR eggNOG; COG2333; Bacteria.
DR OrthoDB; 9761531at2; -.
DR Proteomes; UP000028640; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0030420; P:establishment of competence for transformation; IEA:InterPro.
DR CDD; cd07731; ComA-like_MBL-fold; 1.
DR Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR InterPro; IPR035681; ComA-like_MBL.
DR InterPro; IPR004477; ComEC_N.
DR InterPro; IPR004797; Competence_ComEC/Rec2.
DR InterPro; IPR025405; DUF4131.
DR InterPro; IPR001279; Metallo-B-lactamas.
DR InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR NCBIfam; TIGR00360; ComEC_N-term; 1.
DR NCBIfam; TIGR00361; ComEC_Rec2; 1.
DR PANTHER; PTHR30619; DNA INTERNALIZATION/COMPETENCE PROTEIN COMEC/REC2; 1.
DR PANTHER; PTHR30619:SF1; RECOMBINATION PROTEIN 2; 1.
DR Pfam; PF03772; Competence; 1.
DR Pfam; PF13567; DUF4131; 1.
DR Pfam; PF00753; Lactamase_B; 1.
DR SMART; SM00849; Lactamase_B; 1.
DR SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Hydrolase {ECO:0000313|EMBL:KFC83852.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000028640};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..32
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 44..60
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 222..244
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 281..298
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 328..347
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 359..382
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 394..421
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 447..465
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 471..491
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 508..688
FT /note="Metallo-beta-lactamase"
FT /evidence="ECO:0000259|SMART:SM00849"
SQ SEQUENCE 753 AA; 84377 MW; 79F2950025053D28 CRC64;
MDEIALAAIA GMLPLILLPQ LPGFYICLLM AIGTIAGCWL NHKLSLLAAI LLLSMLWGTH
NGHSLLKQTE SLSLGKKELI AEIKTINLHQ SDSQLVTSKI EHVDGELLFP PVYFRSRWEG
QESYCAGQKW QLNANLRPVH ALLNEGGFDS QRWALANRWP LTGRISSKTV INAECSLRQR
LITHVQQAIA PLDNGAVLMA LAFGEKGLIK PEDKLLMQRT GIAHLIAISG LHIGIAAWFG
YLLARGLQYC LPLKYMDYRF PLIISELTLL TYTWLAGGNA PAVRAAVALS LWLLLRFMRV
KCHPWQIWLW CVALLLMSDP MSILSDSFWL SCFAVAALIF WFQWAPLPKR VGHSWRWAVL
RWAHLQLGMT ILLLPIQVGL FHGVNLASFA ANMWAVPIVS LSTVPLVLLG VMGTGILPAL
ITEKTWFIAD QSLSLAFWGV KRFAGEWFYL SEATVALSLV GWGSVMAWRL GWLSMFPATV
IGVFSVLIVW FNRAEGEKWR VDMVDVGHGL AVLISKNGKG VLYDTGNRWE RGSAAEMNIL
PLMRWRNIQL EQIIISHAHA DHRGGLDAMR KAFPLATLRE STVDSPLPCH AGVSWQWQGL
SFTALWPEKA GVISENDDSC VVRVSDGNFS VLLTGDIETA AERKIVSIYR GALQSTILQV
PHHGSNTSST PPFLRAVAPE LAISSSSRFN KWHLPAQKVM ARYRNAKVAW RDTSRSGQLS
VHFYDKYWRI NGFREQIFPR WYHRRFGVSG DNE
//
