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Database: UniProt
Entry: A0A085GM76_9ENTR
LinkDB: A0A085GM76_9ENTR
Original site: A0A085GM76_9ENTR 
ID   A0A085GM76_9ENTR        Unreviewed;       435 AA.
AC   A0A085GM76;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   24-JAN-2024, entry version 38.
DE   RecName: Full=Isocitrate lyase {ECO:0000256|ARBA:ARBA00017446};
DE            EC=4.1.3.1 {ECO:0000256|ARBA:ARBA00012909};
DE   AltName: Full=Isocitrase {ECO:0000256|ARBA:ARBA00031022};
DE   AltName: Full=Isocitratase {ECO:0000256|ARBA:ARBA00031921};
GN   Name=aceA {ECO:0000313|EMBL:KFC84821.1};
GN   ORFNames=GBAG_0113 {ECO:0000313|EMBL:KFC84821.1};
OS   Buttiauxella agrestis ATCC 33320.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Buttiauxella.
OX   NCBI_TaxID=1006004 {ECO:0000313|EMBL:KFC84821.1, ECO:0000313|Proteomes:UP000028653};
RN   [1] {ECO:0000313|EMBL:KFC84821.1, ECO:0000313|Proteomes:UP000028653}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 33320 {ECO:0000313|EMBL:KFC84821.1,
RC   ECO:0000313|Proteomes:UP000028653};
RA   Plunkett G.III., Neeno-Eckwall E.C., Glasner J.D., Perna N.T.;
RT   "ATOL: Assembling a taxonomically balanced genome-scale reconstruction of
RT   the evolutionary history of the Enterobacteriaceae.";
RL   Submitted (MAY-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-threo-isocitrate = glyoxylate + succinate;
CC         Xref=Rhea:RHEA:13245, ChEBI:CHEBI:15562, ChEBI:CHEBI:30031,
CC         ChEBI:CHEBI:36655; EC=4.1.3.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00023531};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|PIRSR:PIRSR001362-3};
CC       Note=Can also use Mn(2+) ion. {ECO:0000256|PIRSR:PIRSR001362-3};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KFC84821.1}.
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DR   EMBL; JMPI01000004; KFC84821.1; -; Genomic_DNA.
DR   RefSeq; WP_034492345.1; NZ_JMPI01000004.1.
DR   AlphaFoldDB; A0A085GM76; -.
DR   STRING; 1006004.GBAG_0113; -.
DR   eggNOG; COG2224; Bacteria.
DR   OrthoDB; 8629576at2; -.
DR   Proteomes; UP000028653; Unassembled WGS sequence.
DR   GO; GO:0004451; F:isocitrate lyase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0019752; P:carboxylic acid metabolic process; IEA:InterPro.
DR   CDD; cd00377; ICL_PEPM; 1.
DR   Gene3D; 3.20.20.60; Phosphoenolpyruvate-binding domains; 1.
DR   InterPro; IPR039556; ICL/PEPM.
DR   InterPro; IPR006254; Isocitrate_lyase.
DR   InterPro; IPR018523; Isocitrate_lyase_ph_CS.
DR   InterPro; IPR015813; Pyrv/PenolPyrv_Kinase-like_dom.
DR   InterPro; IPR040442; Pyrv_Kinase-like_dom_sf.
DR   NCBIfam; TIGR01346; isocit_lyase; 2.
DR   PANTHER; PTHR21631:SF3; BIFUNCTIONAL GLYOXYLATE CYCLE PROTEIN; 1.
DR   PANTHER; PTHR21631; ISOCITRATE LYASE/MALATE SYNTHASE; 1.
DR   Pfam; PF00463; ICL; 2.
DR   PIRSF; PIRSF001362; Isocit_lyase; 1.
DR   SUPFAM; SSF51621; Phosphoenolpyruvate/pyruvate domain; 1.
DR   PROSITE; PS00161; ISOCITRATE_LYASE; 1.
PE   4: Predicted;
KW   Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000313|EMBL:KFC84821.1};
KW   Magnesium {ECO:0000256|PIRSR:PIRSR001362-3};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR001362-3};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028653}.
FT   ACT_SITE        196
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001362-1"
FT   BINDING         92..94
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001362-2"
FT   BINDING         158
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001362-3"
FT   BINDING         197..198
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001362-2"
FT   BINDING         233
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001362-2"
FT   BINDING         318..322
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001362-2"
FT   BINDING         352
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001362-2"
SQ   SEQUENCE   435 AA;  48055 MW;  8B2AB6C5FED0CA5C CRC64;
     MKTSRNQQIQ QLQEDWTQAR WDGIKRPYSA EEVVKLRGSV NPECTLAQNG AARMWRLLHG
     ESKKGYINSL GALTGGQALQ QAKAGIEAIY LSGWQVAADA NLASSMYPDQ SLYPANSVPA
     VVDRINNTFR RADQIQWASN IEEGDPRYVD YYLPIVADAE AGFGGVLNAF ELMKSMIQAG
     AAAVHFEDQL ASVKKCGHMG GKVLVPTQEA IQKLVAARLA ADVMGVPTLV IARTDADAAD
     LITSDCDEYD REFVTGERTQ EGFYRTRAGI EQAISRGLAY APYADLVWCE TSKPDLEQAR
     RFADAIHARF PGKLLAYNCS PSFNWKKNLD DKTIASFQEE LSAMGYKYQF ITLAGIHSMW
     FNMFDLAHAY AQGEGMRHYV EKVQQPEFAA APEGYTFVSH QQEVGTGYFD RVTTIIQGGA
     SSVTALTGST EEEQF
//
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