GenomeNet

Database: UniProt
Entry: A0A085GPW6_9GAMM
LinkDB: A0A085GPW6_9GAMM
Original site: A0A085GPW6_9GAMM 
ID   A0A085GPW6_9GAMM        Unreviewed;       617 AA.
AC   A0A085GPW6;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   18-SEP-2019, entry version 37.
DE   RecName: Full=Glutathione-regulated potassium-efflux system protein KefC {ECO:0000256|HAMAP-Rule:MF_01413};
DE   AltName: Full=K(+)/H(+) antiporter {ECO:0000256|HAMAP-Rule:MF_01413};
GN   Name=kefC {ECO:0000256|HAMAP-Rule:MF_01413};
GN   ORFNames=GEAM_0237 {ECO:0000313|EMBL:KFC85761.1};
OS   Ewingella americana ATCC 33852.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Ewingella.
OX   NCBI_TaxID=910964 {ECO:0000313|EMBL:KFC85761.1, ECO:0000313|Proteomes:UP000028640};
RN   [1] {ECO:0000313|EMBL:KFC85761.1, ECO:0000313|Proteomes:UP000028640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 33852 {ECO:0000313|EMBL:KFC85761.1,
RC   ECO:0000313|Proteomes:UP000028640};
RA   Plunkett G.III., Neeno-Eckwall E.C., Glasner J.D., Perna N.T.;
RT   "ATOL: Assembling a taxonomically balanced genome-scale reconstruction
RT   of the evolutionary history of the Enterobacteriaceae.";
RL   Submitted (MAY-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Pore-forming subunit of a potassium efflux system that
CC       confers protection against electrophiles. Catalyzes K(+)/H(+)
CC       antiport. {ECO:0000256|HAMAP-Rule:MF_01413}.
CC   -!- SUBUNIT: Homodimer. Interacts with the regulatory subunit KefF.
CC       {ECO:0000256|HAMAP-Rule:MF_01413}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000256|HAMAP-
CC       Rule:MF_01413}; Multi-pass membrane protein {ECO:0000256|HAMAP-
CC       Rule:MF_01413}.
CC   -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 2
CC       (CPA2) transporter (TC 2.A.37) family. KefC subfamily.
CC       {ECO:0000256|HAMAP-Rule:MF_01413}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KFC85761.1}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; JMPJ01000017; KFC85761.1; -; Genomic_DNA.
DR   RefSeq; WP_034787087.1; NZ_JMPJ01000017.1.
DR   STRING; 910964.GEAM_0237; -.
DR   EnsemblBacteria; KFC85761; KFC85761; GEAM_0237.
DR   Proteomes; UP000028640; Unassembled WGS sequence.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0019899; F:enzyme binding; IEA:InterPro.
DR   GO; GO:0015503; F:glutathione-regulated potassium exporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0015299; F:solute:proton antiporter activity; IEA:InterPro.
DR   GO; GO:0015643; F:toxic substance binding; IEA:InterPro.
DR   GO; GO:0051595; P:response to methylglyoxal; IEA:InterPro.
DR   Gene3D; 1.20.1530.20; -; 1.
DR   HAMAP; MF_01413; K_H_efflux_KefC; 1.
DR   InterPro; IPR006153; Cation/H_exchanger.
DR   InterPro; IPR004771; K/H_exchanger.
DR   InterPro; IPR023941; K_H_efflux_KefC.
DR   InterPro; IPR038770; Na+/solute_symporter_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR003148; RCK_N.
DR   PANTHER; PTHR46157:SF3; PTHR46157:SF3; 1.
DR   Pfam; PF00999; Na_H_Exchanger; 1.
DR   Pfam; PF02254; TrkA_N; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   TIGRFAMs; TIGR00932; 2a37; 1.
DR   PROSITE; PS51201; RCK_N; 1.
PE   3: Inferred from homology;
KW   Antiport {ECO:0000256|HAMAP-Rule:MF_01413,
KW   ECO:0000256|SAAS:SAAS00460756};
KW   Cell inner membrane {ECO:0000256|HAMAP-Rule:MF_01413};
KW   Cell membrane {ECO:0000256|HAMAP-Rule:MF_01413};
KW   Complete proteome {ECO:0000313|Proteomes:UP000028640};
KW   Ion transport {ECO:0000256|HAMAP-Rule:MF_01413,
KW   ECO:0000256|SAAS:SAAS01092081};
KW   Membrane {ECO:0000256|HAMAP-Rule:MF_01413,
KW   ECO:0000256|SAAS:SAAS00460792};
KW   Potassium {ECO:0000256|HAMAP-Rule:MF_01413};
KW   Potassium transport {ECO:0000256|HAMAP-Rule:MF_01413};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028640};
KW   Transmembrane {ECO:0000256|HAMAP-Rule:MF_01413,
KW   ECO:0000256|SAAS:SAAS00460753};
KW   Transmembrane helix {ECO:0000256|HAMAP-Rule:MF_01413,
KW   ECO:0000256|SAAS:SAAS00460739};
KW   Transport {ECO:0000256|HAMAP-Rule:MF_01413,
KW   ECO:0000256|SAAS:SAAS01092095}.
FT   TRANSMEM     56     75       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01413}.
FT   TRANSMEM     87    110       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01413}.
FT   TRANSMEM    116    136       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01413}.
FT   TRANSMEM    148    170       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01413}.
FT   TRANSMEM    182    204       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01413}.
FT   TRANSMEM    240    259       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01413}.
FT   TRANSMEM    271    289       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01413}.
FT   TRANSMEM    295    315       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01413}.
FT   TRANSMEM    327    351       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01413}.
FT   TRANSMEM    357    378       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01413}.
FT   DOMAIN      402    524       RCK N-terminal. {ECO:0000259|PROSITE:
FT                                PS51201}.
FT   REGION      590    617       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
SQ   SEQUENCE   617 AA;  66678 MW;  A20C5C6496509218 CRC64;
     MENHNLLLEG LLYLGSAALF VPIAVRLGLG SVLGYLIAGC IIGPWGLKLV SDPESILTFA
     EIGVVLMLFI IGLELDPKRL WTLRASVFGG GSIQMGGCGL VLSLFCYLLG LDWKVALLIG
     LTLALSSTAI AMQAMSERSL TTSPIGRSAF AVLLFQDIAA IPLVAMIPLL ASTGEATTLA
     SFGLSAAKVV GALAAVILLG RYVARPLLHF VARSGMREVF SAVALFLVFG FGILLETAGL
     SMAMGAFLAG VMLASSEYRH ALESDIQPFK GLLLGLFFIG VGMSIDFGTL VHQPLLIATL
     LVGFMLLKAA LLWLIGPLLG VPKRQRGLFA ILIGQGSEFA FVIFSTAQMA GVLPVEWAKA
     LTLAVALSMA VTPLLLVLAS RLERNAPKDT RPDDTIDDEN ATVIIAGFGR FGQIAGRLLL
     ANNVHTVVLD HDPDHIETLR KFGTKVFYGD ATRVDLLESA GAGQAKVLIN AIDDVEANLQ
     LTELAKEHFP NLKIIARARD VDHWYQLRRL GVEAPERELF EGSLRVGRET LEFLGLDAYE
     AREKADLFRR YNSKMLEATI ENYEDTEFRV ATMQRAKDML TDAIEQDQKR LASGQQQGWR
     GSIDGKAPED EVIEAKG
//
DBGET integrated database retrieval system