ID A0A085LFQ1_9MICO Unreviewed; 894 AA.
AC A0A085LFQ1;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=DNA ligase (ATP) {ECO:0000256|ARBA:ARBA00012727};
DE EC=6.5.1.1 {ECO:0000256|ARBA:ARBA00012727};
DE AltName: Full=NHEJ DNA polymerase {ECO:0000256|ARBA:ARBA00029943};
GN ORFNames=IU11_08300 {ECO:0000313|EMBL:KFD43797.1};
OS Cellulosimicrobium sp. MM.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales;
OC Promicromonosporaceae; Cellulosimicrobium.
OX NCBI_TaxID=1523621 {ECO:0000313|EMBL:KFD43797.1, ECO:0000313|Proteomes:UP000028634};
RN [1] {ECO:0000313|EMBL:KFD43797.1, ECO:0000313|Proteomes:UP000028634}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MM {ECO:0000313|EMBL:KFD43797.1,
RC ECO:0000313|Proteomes:UP000028634};
RA Lal R., Sharma A., Sangwan N., Hira P.;
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:KFD43797.1, ECO:0000313|Proteomes:UP000028634}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MM {ECO:0000313|EMBL:KFD43797.1,
RC ECO:0000313|Proteomes:UP000028634};
RA Khurana J.P.;
RT "Draft genome sequence of Cellulosimicrobium sp. MM isolated from arsenic
RT rich microbial mats of a himalayan hotspring.";
RL Submitted (AUG-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-
CC (deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP +
CC diphosphate.; EC=6.5.1.1; Evidence={ECO:0000256|ARBA:ARBA00034003};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KFD43797.1}.
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DR EMBL; JPQW01000139; KFD43797.1; -; Genomic_DNA.
DR RefSeq; WP_034653482.1; NZ_JPQW01000139.1.
DR AlphaFoldDB; A0A085LFQ1; -.
DR Proteomes; UP000028634; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR CDD; cd07906; Adenylation_DNA_ligase_LigD_LigC; 1.
DR CDD; cd04863; MtLigD_Pol_like; 1.
DR CDD; cd07971; OBF_DNA_ligase_LigD; 1.
DR Gene3D; 3.30.1490.70; -; 1.
DR Gene3D; 3.30.470.30; DNA ligase/mRNA capping enzyme; 1.
DR Gene3D; 3.90.920.10; DNA primase, PRIM domain; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR InterPro; IPR012309; DNA_ligase_ATP-dep_C.
DR InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR InterPro; IPR014146; LigD_ligase_dom.
DR InterPro; IPR014144; LigD_PE_domain.
DR InterPro; IPR014145; LigD_pol_dom.
DR InterPro; IPR033649; MtLigD_Pol-like.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR NCBIfam; TIGR02777; LigD_PE_dom; 1.
DR NCBIfam; TIGR02778; ligD_pol; 1.
DR NCBIfam; TIGR02779; NHEJ_ligase_lig; 1.
DR PANTHER; PTHR42705; BIFUNCTIONAL NON-HOMOLOGOUS END JOINING PROTEIN LIGD; 1.
DR PANTHER; PTHR42705:SF2; MULTIFUNCTIONAL NON-HOMOLOGOUS END JOINING DNA REPAIR PROTEIN LIGD; 1.
DR Pfam; PF04679; DNA_ligase_A_C; 1.
DR Pfam; PF01068; DNA_ligase_A_M; 1.
DR Pfam; PF13298; LigD_N; 1.
DR Pfam; PF21686; LigD_Prim-Pol; 1.
DR SUPFAM; SSF56091; DNA ligase/mRNA capping enzyme, catalytic domain; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR PROSITE; PS50160; DNA_LIGASE_A3; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:KFD43797.1};
KW Manganese {ECO:0000256|ARBA:ARBA00023211};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Reference proteome {ECO:0000313|Proteomes:UP000028634};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 664..788
FT /note="ATP-dependent DNA ligase family profile"
FT /evidence="ECO:0000259|PROSITE:PS50160"
FT REGION 311..335
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 341..360
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 487..573
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 514..534
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 894 AA; 97420 MW; 90C7EF9D08841AD3 CRC64;
MATTSSRTGE TVNVGGHRLR LTNLDKVLYP ATGTTKADVL AYLAAVADVM LPHCANRPAT
RKRWPDGVDG QVFFQKNAGQ GVPSWVRTRR IQHKSSANDY VLVNDLATLT WLGQTASLEL
HVPQWQFGRT GAHLDPDRLV LDLDPGPGAG LAECAEVARQ ARQILQGMGL EPLPVTSGSK
GIHLYAALDG KQDAAAVSAV AHELARYLEA EHPDLVVSDM KKSLRGGKVL VDWSQNNGNK
TTIAPYSLRG REHPTVAAPR TWEELDDPDL RHLDLDEVVE RVRTLGEPLA ALTQGHLSAL
EPTPARMATF ERKGGAASGG DAADGGTDDE RPDRLHRYRS MRDAGRTPEP VPDEAPPPSA
GNSFVIQEHH ARRLHWDFRL EHDGVLVSWA LPRGEPTDPK KNHLAVQTED HPLAYGSFEG
TIPKGEYGAG EVTIWDAGTY ELEKWRDGEE VIVTLHGEQH GTRRLALIHT GGRDGRDEDN
WLIHLMAPRP SRPGESPRGR GAGGGEEVPG LPSAARPSPL PPDPPRPGTS SPPPASPSAR
GASSPDHDDT PEPRPARTDW RPMLASPASA GDLHDGDAWA FEMKWDGFRT LAHVSEGRVR
LVSRSGKDMS VTYPELQALA EQVPAEALPV VLDGEIVALD ARGRPSFRRL QQRANIAKPG
DVAAARRRVT VDLMVFDVLE TGGRSLAKRP YDERREVLED VLRDAVAPVH VPPVFDGDLE
AAMETSRRLG LEGVVAKRRD GTYSSGRRSA LWLKLKHAQS QEVVVVGWRP GHGERTHLVG
SLLLAVPDDG RLVYVGRVGS GFTDAERRDL VAELDRIGRT TPPAVGVPRE DARDAHWVSP
RRVAEVVYAE WTGAGEGDGD DVPFGKLRHP VWKGWRRDKS PDDVVLEAPA TFEG
//