ID A0A085MAA4_9BILA Unreviewed; 2267 AA.
AC A0A085MAA4;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=Protein, SNF2 family {ECO:0008006|Google:ProtNLM};
GN ORFNames=M513_04927 {ECO:0000313|EMBL:KFD54150.1}, M514_04927
GN {ECO:0000313|EMBL:KFD71229.1};
OS Trichuris suis (pig whipworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichuridae; Trichuris.
OX NCBI_TaxID=68888 {ECO:0000313|EMBL:KFD54150.1, ECO:0000313|Proteomes:UP000030764};
RN [1] {ECO:0000313|EMBL:KFD54150.1, ECO:0000313|Proteomes:UP000030764}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DCEP-RM93F {ECO:0000313|EMBL:KFD71229.1}, and DCEP-RM93M
RC {ECO:0000313|EMBL:KFD54150.1};
RX PubMed=24929829; DOI=10.1038/ng.3012;
RA Jex A.R., Nejsum P., Schwarz E.M., Hu L., Young N.D., Hall R.S.,
RA Korhonen P.K., Liao S., Thamsborg S., Xia J., Xu P., Wang S.,
RA Scheerlinck J.P., Hofmann A., Sternberg P.W., Wang J., Gasser R.B.;
RT "Genome and transcriptome of the porcine whipworm Trichuris suis.";
RL Nat. Genet. 46:701-706(2014).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily.
CC {ECO:0000256|ARBA:ARBA00009220}.
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DR EMBL; KL363210; KFD54150.1; -; Genomic_DNA.
DR EMBL; KL367483; KFD71229.1; -; Genomic_DNA.
DR Proteomes; UP000030758; Unassembled WGS sequence.
DR Proteomes; UP000030764; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0140658; F:ATP-dependent chromatin remodeler activity; IEA:InterPro.
DR CDD; cd18003; DEXQc_SRCAP; 1.
DR CDD; cd18793; SF2_C_SNF; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.20.120.850; SWI2/SNF2 ATPases, N-terminal domain; 1.
DR Gene3D; 3.40.50.10810; Tandem AAA-ATPase domain; 1.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR014012; HSA_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038718; SNF2-like_sf.
DR InterPro; IPR049730; SNF2/RAD54-like_C.
DR InterPro; IPR000330; SNF2_N.
DR PANTHER; PTHR45685:SF1; HELICASE SRCAP; 1.
DR PANTHER; PTHR45685; HELICASE SRCAP-RELATED; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07529; HSA; 1.
DR Pfam; PF00176; SNF2-rel_dom; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00573; HSA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS51204; HSA; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 203..276
FT /note="HSA"
FT /evidence="ECO:0000259|PROSITE:PS51204"
FT DOMAIN 493..658
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 1240..1402
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 322..429
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1011..1075
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1634..1654
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1500..1553
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 328..348
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 356..370
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 371..386
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 391..415
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1030..1048
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2267 AA; 254089 MW; D816B55AA286D6E5 CRC64;
MGIIEEADNA ATDSCLSTLE VQEPTTSRAL SADSVGDGAV ASDEELGLRA VTRLIEKEAL
GSFICGLRAV GTNECTFSEP KTSSAAARIN TGTVIPDHLE PLCPCSSLPD EPKEQNEVLY
IEEHSIESAE AGSSRSSPSD GYIDLTAGSS RQKRTSCDGE PSLVKTGAIN SEKDTTAAIR
QEATIMRRIG ELRKMGCWSQ SLLPKCSEPR RLKSYWDNFI AEACWMSKDF AEERKLKKFA
GKKMAAACSK AVRDKSERTR RLYLERQKQR KRVSSQENKL VRQLWLQVDK IVAYRNDAII
KAKREKALNA HLNIILGDPE KSAATVPKNH ERSLTAESGT TDGQEKEVSL KANASKVSGR
KRRKGFNSAR RIKQPRLDEP VDDELASKAA PDQSPSRSAS SDNESETSGS EVDEPMQSET
EPPEKSDDWI DYEKLQSTDS AERQGQLACI AEAAEKLQPK GYTLESVEEE IKVPFLLKHK
LREYQLVGLH WLITLNRKGL NGILADEMGL GKTIQTIALL AHLACENFDW GPHLVIVPTS
VLLNWEMEFK KWCPSFKILT YYGHLKERKE KRRGWCKDNN FHICITSYKL VVQDYSTFRR
RKWHYMILDE AQNIKNFKSM RWQALLNFNT TRRLLLTGTP LQNSLMELWS LMHFLMPNVF
QSHSDFREWF SNPLTNMIDG SVEFDEQLVK RLHKVLRPFL LRRLKSEVER QLPKKFEHVM
MCELSKRQRY LYNEFMSRSS TRSQLASGNV INVIGILMQL RKVCNHPNLF EPRPVVSPLW
MPAIMWRVPG FCCDMHLGSV GKVPVWLRST SWRKLMRTEC RTLDTLTVSQ SESRLASSQL
SSSPSTIGSP RSYHCFRTTL RENAARIYFD SPNPRQFRAE IPCTLKQCHV PLKATTKIGA
NMVNLNGQMK VTTSYIRASV KVNDGESKKE VLLRLVRKTP VEGAAAAPPA PPVDPTMPKL
SLPVRIVESR SPVSSFSSDR PPALVKSQIP VLNSIPRSSS DSTAQPIRPC KAELLPDSDL
YEPTSSPIRK TAKYDYSTSP SSTASEHRRL SVKTPHESGP SSSAVADTTE EEDEDMSLFT
EAAVGSLCEA VRHLLEAERA NPWVECDLHV EEELKAMKEH IEFIGRMRAL RSPDCTVGCL
ETFLIPKMEV NLNFRERLVA QWQYIHDRAA LYIPGVCTTR VEPVISHRFP YEDLYEASLE
KKCQEYLNDA LQPYREFLLS RSLLFPESSL IEYDCGKLHV LANILRDLRA NGHRCLIFTQ
MARMLDILEI FLSHHGYKYL RLDGATGVER RQVLMERFNE DRRILCFILS TRSGGLGVNL
TGADTVIFYD SDWNPTMDAQ AQDRCHRIGQ TRDVNIYRLI CARTVEENIL IKANQKRKLG
ELAIEEGCFR PNFLRETIRE MFYLPDADTT PAGGENVTDG ELQQAMADAE DDTDVVAAKV
ASAEAAFDKE DFEENEELQQ KQLVPSDANV EQLDPEVAKV DLEMKEMLCE LTPIERFGLM
NLSSRRQHEL FEELREAEDE VEQYRRSFAE TRKQELELEK ARAQELRKQE FQLTYDAQDE
HCKVSRSFDG QEEDGPLCRV AEDEGSDAEL TCKEIDSDDE TTRKIVIRSR QARGKASRSN
DCLDASDASI AINGYRDDPP VDGSFGNDHH PLPDDCVKRK RTMIAEDSSV MPIWDPPTPP
LSDGEDCYAT VNDDAWGPYL RTPMGELPLC VEDTEQKDFF IAAGLPSPTS PVQEKQPSSA
EAVATVLDGP GEARDSKENL VSSIQLSAAS IRSSIADHRT FSSILEPLSA DGSVAAPLPK
NVTDDCTVCY LGDRLLAPSY GVGRCRNANV NWDYVSEYML AQKKCVISPR KCLTQCESRR
SLRGQQKTEL GPLVCSTYPP IESGGTEAVA SPTLCSVSLL RASFGAQYGF PNAKVFGMAY
LSSAKEESSS TLPPLPSDLY LGKLKYFLCI YSALCFSQKG LLRFSEGRCI DCERLGPQVR
QYALKYQQAA RPDASKCISK LPRLEENDEE RYLTLASNSM MSNLTFLSSV GATHHPAAPF
PDTDAKFQAS SSSAKTANSQ FRQVLSAGSQ PYMLNVGNGM DMVLPEYSVI GQPVDSSGFS
RSHGHFMRVK PTQLASRSAA TTGGSRRELG SRGTLVPIIS SNHSYQSQVQ VRPKPVFPHA
RMHVSAQRGF TAIQHHQRIR SPTQLSGVRH VSFSGQSPIL PSCSRPISIR SIRPRQPNTL
IASPPVGHSE ARHLRPQLRS IPSINMIMSG CPQKSLIDDV SDSSANR
//
