ID A0A085MAW4_9BILA Unreviewed; 270 AA.
AC A0A085MAW4;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 22-FEB-2023, entry version 25.
DE RecName: Full=GPN-loop GTPase 3 {ECO:0000256|ARBA:ARBA00014587, ECO:0000256|RuleBase:RU365059};
GN ORFNames=D918_07657 {ECO:0000313|EMBL:KHJ42318.1}, M513_04703
GN {ECO:0000313|EMBL:KFD54360.1}, M514_04703
GN {ECO:0000313|EMBL:KFD65814.1};
OS Trichuris suis (pig whipworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichuridae; Trichuris.
OX NCBI_TaxID=68888 {ECO:0000313|EMBL:KFD54360.1, ECO:0000313|Proteomes:UP000030764};
RN [1] {ECO:0000313|EMBL:KFD54360.1, ECO:0000313|Proteomes:UP000030764}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DCEP-RM93F {ECO:0000313|EMBL:KFD65814.1}, and DCEP-RM93M
RC {ECO:0000313|EMBL:KFD54360.1};
RX PubMed=24929829; DOI=10.1038/ng.3012;
RA Jex A.R., Nejsum P., Schwarz E.M., Hu L., Young N.D., Hall R.S.,
RA Korhonen P.K., Liao S., Thamsborg S., Xia J., Xu P., Wang S.,
RA Scheerlinck J.P., Hofmann A., Sternberg P.W., Wang J., Gasser R.B.;
RT "Genome and transcriptome of the porcine whipworm Trichuris suis.";
RL Nat. Genet. 46:701-706(2014).
RN [2] {ECO:0000313|EMBL:KHJ42318.1, ECO:0000313|Proteomes:UP000053709}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mitreva M.;
RT "Draft genome of Trichuris suis.";
RL Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Small GTPase required for proper localization of RNA
CC polymerase II (RNAPII). May act at an RNAP assembly step prior to
CC nuclear import. {ECO:0000256|ARBA:ARBA00002411}.
CC -!- FUNCTION: Small GTPase required for proper nuclear import of RNA
CC polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly
CC step prior to nuclear import. {ECO:0000256|RuleBase:RU365059}.
CC -!- SUBUNIT: Binds to RNA polymerase II (RNAPII).
CC {ECO:0000256|RuleBase:RU365059}.
CC -!- SIMILARITY: Belongs to the GPN-loop GTPase family.
CC {ECO:0000256|ARBA:ARBA00005290, ECO:0000256|RuleBase:RU365059}.
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DR EMBL; KL363208; KFD54360.1; -; Genomic_DNA.
DR EMBL; KL367532; KFD65814.1; -; Genomic_DNA.
DR EMBL; KN538405; KHJ42318.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A085MAW4; -.
DR Proteomes; UP000030758; Unassembled WGS sequence.
DR Proteomes; UP000030764; Unassembled WGS sequence.
DR Proteomes; UP000053709; Unassembled WGS sequence.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR CDD; cd17872; GPN3; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR004130; Gpn.
DR InterPro; IPR030228; Gpn3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR21231:SF7; GPN-LOOP GTPASE 3; 1.
DR PANTHER; PTHR21231; XPA-BINDING PROTEIN 1-RELATED; 1.
DR Pfam; PF03029; ATP_bind_1; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|RuleBase:RU365059};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU365059};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU365059};
KW Reference proteome {ECO:0000313|Proteomes:UP000053709}.
SQ SEQUENCE 270 AA; 30433 MW; 31CF96C69DBC7AB3 CRC64;
MRYGQVVIGP AGSGKSTFCK TVSEYGASSS RLIKVVNLDP AADHFDYTCY ADVRNLISLD
DVIQDESLCL GPNGGLVFCM EYLAQNLNWL EEELGEGDDD YFLFDCPGQL ELYTHAPVMK
MIVEELKRMN FNLCAVFTLD TQFLLDVPKF MSGSLAALSA MINLELPHVN VLTKMDLLAE
SSKRRLEAFI DADPRLVETV EDVDRFSVKY RRLTQSLSSL LENYSLVKYV PFDISDEETI
GDLLLIIDSA VQYGDDLEVR DRLPEMEDDE
//
