ID A0A085MKY2_9BILA Unreviewed; 650 AA.
AC A0A085MKY2;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=Phosphate transporter {ECO:0000256|RuleBase:RU363058};
GN ORFNames=M513_01111 {ECO:0000313|EMBL:KFD57878.1}, M514_01111
GN {ECO:0000313|EMBL:KFD62594.1};
OS Trichuris suis (pig whipworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichuridae; Trichuris.
OX NCBI_TaxID=68888 {ECO:0000313|EMBL:KFD57878.1, ECO:0000313|Proteomes:UP000030764};
RN [1] {ECO:0000313|EMBL:KFD57878.1, ECO:0000313|Proteomes:UP000030764}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DCEP-RM93F {ECO:0000313|EMBL:KFD62594.1}, and DCEP-RM93M
RC {ECO:0000313|EMBL:KFD57878.1};
RX PubMed=24929829; DOI=10.1038/ng.3012;
RA Jex A.R., Nejsum P., Schwarz E.M., Hu L., Young N.D., Hall R.S.,
RA Korhonen P.K., Liao S., Thamsborg S., Xia J., Xu P., Wang S.,
RA Scheerlinck J.P., Hofmann A., Sternberg P.W., Wang J., Gasser R.B.;
RT "Genome and transcriptome of the porcine whipworm Trichuris suis.";
RL Nat. Genet. 46:701-706(2014).
CC -!- FUNCTION: Sodium-phosphate symporter. {ECO:0000256|RuleBase:RU363058}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 Na(+)(out) + phosphate(out) = 2 Na(+)(in) + phosphate(in);
CC Xref=Rhea:RHEA:71259, ChEBI:CHEBI:29101, ChEBI:CHEBI:43474;
CC Evidence={ECO:0000256|ARBA:ARBA00035083};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU363058}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU363058}.
CC -!- SIMILARITY: Belongs to the inorganic phosphate transporter (PiT) (TC
CC 2.A.20) family. {ECO:0000256|ARBA:ARBA00009916,
CC ECO:0000256|RuleBase:RU363058}.
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DR EMBL; KL363186; KFD57878.1; -; Genomic_DNA.
DR EMBL; KL367592; KFD62594.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A085MKY2; -.
DR Proteomes; UP000030758; Unassembled WGS sequence.
DR Proteomes; UP000030764; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005315; F:inorganic phosphate transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR GO; GO:0006817; P:phosphate ion transport; IEA:UniProtKB-KW.
DR InterPro; IPR001204; Phos_transporter.
DR PANTHER; PTHR11101; PHOSPHATE TRANSPORTER; 1.
DR PANTHER; PTHR11101:SF80; SODIUM-DEPENDENT PHOSPHATE TRANSPORTER 2; 1.
DR Pfam; PF01384; PHO4; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU363058};
KW Phosphate transport {ECO:0000256|ARBA:ARBA00022592,
KW ECO:0000256|RuleBase:RU363058}; Signal {ECO:0000256|SAM:SignalP};
KW Symport {ECO:0000256|ARBA:ARBA00022847};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU363058};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU363058};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU363058}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..650
FT /note="Phosphate transporter"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010405304"
FT TRANSMEM 44..63
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363058"
FT TRANSMEM 83..105
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363058"
FT TRANSMEM 137..159
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363058"
FT TRANSMEM 179..197
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363058"
FT TRANSMEM 209..232
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363058"
FT TRANSMEM 383..402
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363058"
FT TRANSMEM 417..436
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363058"
SQ SEQUENCE 650 AA; 71657 MW; 660526782B951896 CRC64;
MDYIWIVVAG FLFAFFLSFS IGANDTANSF GTSVGSKVLT LRKAYILATI FETCGAILLG
SKVTDTMRSG VIDAAVYNQS EKAFISGQLA TLSGCGVWMM LATLFKLPVS TTHSMVGATL
GYSIVLRHFQ GVRWLNIGYI VASWFLSPIL SGLITTVFYM TINASILKRD QAAMRGLNLL
PYFYFFTFLI NIFSVFYDGS AILKFNEIPF WAICLVSVVL SFMTAMAVRI TVVPKLRRKL
TSQVQLEMIA KKTSMEKQQE RKDTLQHMNL IENRLANMDN PDNPLGNEIV YIANFGIENI
LLAVKAIRNT DKTETGIQKL KKYLSPVDQE DPQCVKLFSF LQILSACFSG FAHGGNDVSN
SIAPLVTIWN MYEKGPAGIE DGVPIWLLAY GSAGMSIGLW MLGHRVIRTV GEGLTELNAI
SGFCVELAAA FTVLFASKLG LPISTTHCKI GSVVAVGYIR FARKVNLALF RNIILSWVVT
LPATARETVV NLCGDKTMSI PVVKILVSVA MTEEGNEHIR TVTEIMNALS LPYTIVNGID
QRFTISEGIT IETLAHIRQE LFPLFFQNGA YLGNILQFYA AYWEGNIRLF FPCLFQLDSM
IRTNTSADDT STTEGTTSVY GSNGTDSSLS VYCGLSDDSS NWASSDEEDF
//
