ID A0A085MWC7_9BILA Unreviewed; 605 AA.
AC A0A085MWC7;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 08-NOV-2023, entry version 30.
DE RecName: Full=DNA repair metallo-beta-lactamase domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=M514_26336 {ECO:0000313|EMBL:KFD61523.1};
OS Trichuris suis (pig whipworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichuridae; Trichuris.
OX NCBI_TaxID=68888 {ECO:0000313|EMBL:KFD61523.1};
RN [1] {ECO:0000313|EMBL:KFD61523.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DCEP-RM93F {ECO:0000313|EMBL:KFD61523.1};
RX PubMed=24929829; DOI=10.1038/ng.3012;
RA Jex A.R., Nejsum P., Schwarz E.M., Hu L., Young N.D., Hall R.S.,
RA Korhonen P.K., Liao S., Thamsborg S., Xia J., Xu P., Wang S.,
RA Scheerlinck J.P., Hofmann A., Sternberg P.W., Wang J., Gasser R.B.;
RT "Genome and transcriptome of the porcine whipworm Trichuris suis.";
RL Nat. Genet. 46:701-706(2014).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA repair metallo-beta-lactamase (DRMBL)
CC family. {ECO:0000256|ARBA:ARBA00010304}.
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DR EMBL; KL367621; KFD61523.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A085MWC7; -.
DR Proteomes; UP000030758; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006974; P:DNA damage response; IEA:UniProtKB-KW.
DR CDD; cd16273; SNM1A-1C-like_MBL-fold; 1.
DR Gene3D; 3.40.50.12650; -; 1.
DR Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR InterPro; IPR011084; DRMBL.
DR InterPro; IPR001279; Metallo-B-lactamas.
DR InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR PANTHER; PTHR23240:SF6; DNA CROSS-LINK REPAIR 1A PROTEIN; 1.
DR PANTHER; PTHR23240; DNA CROSS-LINK REPAIR PROTEIN PSO2/SNM1-RELATED; 1.
DR Pfam; PF07522; DRMBL; 1.
DR Pfam; PF12706; Lactamase_B_2; 1.
DR SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242}.
FT DOMAIN 178..339
FT /note="Metallo-beta-lactamase"
FT /evidence="ECO:0000259|Pfam:PF12706"
FT DOMAIN 393..492
FT /note="DNA repair metallo-beta-lactamase"
FT /evidence="ECO:0000259|Pfam:PF07522"
FT REGION 81..109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 605 AA; 68058 MW; 750565A0414751F0 CRC64;
MAFDVWAYKD LKSRLRKRSS KQDDQLGVLV EAKAERAMQR RLFCVLSLCS SGVECFSITS
FIKVKEKFIV SEMVDYSESL QSSSRTSPKD VDLNNTNHPP PVASSNSVQI TSQQQTKLTA
FFTCSGRIAS RAKFPETKSG NEKVLQEFAG RKNSSKCPFF KFIPGTSCVV DAFMYGYLPK
VQMYFLSHFH SDHYSGLNRR FSMPIYCSKV IVNATMSAEV AFAHYQVTAR LVALKLKVDR
RFLHVLELNH WSILPDGTAV MAIDANHCPG ALMFIFKTKN GENILHTGDF RAEDIILQNS
VWEQVQIDVI LLDTTYCDPE YVFPKQHVVI SQALDFIQAK MKIHPKLLIV IGAYTIGKER
IFAAIAEAFD CKICVERSKM QVLNCIDDAS LRARLTLQKT DTFLHVMPMA SVTRKKLTEY
LKVYPTYEHV LGILPTGWQI GSVRRSLLEP LEETNAVTLL GVPYSEHSSY VELKRFVQRV
RPERIIPTVN TSDKEARLSM AQTFSRCSPS ANFEKPIFRS CAVAGYSTFL PKILISTGIK
LQCISFFCRS GCAQQAAEQI AGDKENHFTV CTENGNKILA HITQAASLPL FLCVDLHRAA
AFNAT
//
