ID A0A085MXJ2_9BILA Unreviewed; 690 AA.
AC A0A085MXJ2;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 13-SEP-2023, entry version 22.
DE RecName: Full=SH2 domain-containing protein {ECO:0008006|Google:ProtNLM};
DE Flags: Fragment;
GN ORFNames=M514_07690 {ECO:0000313|EMBL:KFD61938.1};
OS Trichuris suis (pig whipworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichuridae; Trichuris.
OX NCBI_TaxID=68888 {ECO:0000313|EMBL:KFD61938.1};
RN [1] {ECO:0000313|EMBL:KFD61938.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DCEP-RM93F {ECO:0000313|EMBL:KFD61938.1};
RX PubMed=24929829; DOI=10.1038/ng.3012;
RA Jex A.R., Nejsum P., Schwarz E.M., Hu L., Young N.D., Hall R.S.,
RA Korhonen P.K., Liao S., Thamsborg S., Xia J., Xu P., Wang S.,
RA Scheerlinck J.P., Hofmann A., Sternberg P.W., Wang J., Gasser R.B.;
RT "Genome and transcriptome of the porcine whipworm Trichuris suis.";
RL Nat. Genet. 46:701-706(2014).
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DR EMBL; KL367606; KFD61938.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A085MXJ2; -.
DR Proteomes; UP000030758; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR PANTHER; PTHR14247; BREAST CANCER ANTI-ESTROGEN RESISTANCE PROTEIN 3 HOMOLOG-LIKE PROTEIN; 1.
DR PANTHER; PTHR14247:SF8; RAS-GEF DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00017; SH2; 1.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50001; SH2; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|PROSITE-ProRule:PRU00168};
KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191}.
FT DOMAIN 65..164
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 408..640
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 246..275
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 690
FT /evidence="ECO:0000313|EMBL:KFD61938.1"
SQ SEQUENCE 690 AA; 78725 MW; 69A9DDF13D0BA1E0 CRC64;
MLLPCLGKSM DAFQQRHRFF PNKRNDAPKS ITALLIQMKR LIKSYHRNFA KCRAKMPERI
EDNYWYHGSI DRSRAEALVL YSGHFLVRDS CTRNDEYVIT CNWQGCPTHF PIVRSSTQPN
TIYERVVYKV EDETFDSVPA LIRFYVGNKK PLTRSSHCII SCPVNRPPGS SLTKANNLSA
EKSISRDSGI YQSSAGSSAK NISIPELPAY MRNRPLPKLP CQLPSLDRTK WSSEMMLTRT
GKRLALNASD RDLARRPNFD EANQPPPKPT VAPSMKHDGM VIVRSTGGNF EALPAKDFDD
YHEYCDIDYD ELSLTPVNDH PADMSRECVS PKLPARKQHI ERDSACDVDM SIYDQPTSSK
LVDIETIKVR LSSRINVKAY KSNRLPDDVK PMDSRVWPAI RKDLLEADAS DLARCITSAD
RHLLTSNQAE KFHPLIPCDL SLLLLPQGES MRNDLKEKAT CLKHFVQMSI LSADTLLDRI
KMMTKWIEVA DQLRNKLGNL FSFSSVMAAL GSRQLASLNS HWFHLRSEHT HVALLYETKL
RSLYVCRRDS AENGTFVPSI PDLWTVLRLF EADPRKGDTL HDLADPDDQF YGLETLWDEL
VATRQWQCEV KNLFAEFPTR NDVQHAGEKD AVPSALRELF ETEFHIKALW GAKASLVQSK
ERYDKLDDLL SLLAQRRESE LTDQFKSLAT
//
