ID A0A085N505_9BILA Unreviewed; 432 AA.
AC A0A085N505;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 22-FEB-2023, entry version 25.
DE RecName: Full=SAM domain-containing protein {ECO:0000259|PROSITE:PS50105};
GN ORFNames=M513_09746 {ECO:0000313|EMBL:KFD49383.1}, M514_09746
GN {ECO:0000313|EMBL:KFD64551.1};
OS Trichuris suis (pig whipworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichuridae; Trichuris.
OX NCBI_TaxID=68888 {ECO:0000313|EMBL:KFD64551.1};
RN [1] {ECO:0000313|EMBL:KFD64551.1, ECO:0000313|Proteomes:UP000030764}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DCEP-RM93F {ECO:0000313|EMBL:KFD64551.1}, and DCEP-RM93M
RC {ECO:0000313|EMBL:KFD49383.1};
RX PubMed=24929829; DOI=10.1038/ng.3012;
RA Jex A.R., Nejsum P., Schwarz E.M., Hu L., Young N.D., Hall R.S.,
RA Korhonen P.K., Liao S., Thamsborg S., Xia J., Xu P., Wang S.,
RA Scheerlinck J.P., Hofmann A., Sternberg P.W., Wang J., Gasser R.B.;
RT "Genome and transcriptome of the porcine whipworm Trichuris suis.";
RL Nat. Genet. 46:701-706(2014).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the sphingomyelin synthase family.
CC {ECO:0000256|ARBA:ARBA00005441}.
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DR EMBL; KL363272; KFD49383.1; -; Genomic_DNA.
DR EMBL; KL367554; KFD64551.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A085N505; -.
DR Proteomes; UP000030758; Unassembled WGS sequence.
DR Proteomes; UP000030764; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016780; F:phosphotransferase activity, for other substituted phosphate groups; IEA:InterPro.
DR GO; GO:0006665; P:sphingolipid metabolic process; IEA:UniProtKB-KW.
DR CDD; cd09515; SAM_SGMS1-like; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR045221; Sphingomyelin_synth-like.
DR InterPro; IPR025749; Sphingomyelin_synth-like_dom.
DR PANTHER; PTHR21290:SF25; SPHINGOMYELIN SYNTHASE-RELATED PROTEIN 1; 1.
DR PANTHER; PTHR21290; SPHINGOMYELIN SYNTHETASE; 1.
DR Pfam; PF14360; PAP2_C; 1.
DR Pfam; PF00536; SAM_1; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
PE 3: Inferred from homology;
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022919};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Sphingolipid metabolism {ECO:0000256|ARBA:ARBA00022919};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 119..140
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 160..186
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 198..224
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 7..73
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
SQ SEQUENCE 432 AA; 50019 MW; 5048A55771A530BE CRC64;
MKPLEEWTTE DVATWLVNEG FEQHVDLLCW QHKIDGRALL ELNEQDLRLP PLQMPVLGEI
KRLWVALLRL RQERASSASS VHEHSTTSVF SNFEEFSADL LIAEIESADT RNKSILKTIL
AGLYFAVSIL ITSLVMVIVH DRVPDSKTFP PLPDIFLDNI PLIPWAFDAC EILACFLGSI
WTLVVLFHKH RLILMRRFFS LVGTVFMLRC VTIMITSLSV PGVHLDCKAR HSDWPTKLYR
AYEIWYGLGL SLFNVRSCGD YMFSGHTTVV TMFNHFITEY TPDNWNYLHT MSWVCNLFAI
FFILAAHEHY SLDVFVAFYI SSRLFLYYHS LAYHAQAVSS GDSRTRIWFP LFWFFESGGQ
VGRVPNEYEW PLPSLSTLSS YVNGLALIRS CREELTKMRS VYRIHFHKVQ HFLLDRSGGQ
RVTLQEDISK NE
//
