ID A0A085N949_9BILA Unreviewed; 467 AA.
AC A0A085N949;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=Tyrosinase copper-binding domain-containing protein {ECO:0000259|PROSITE:PS00497, ECO:0000259|PROSITE:PS00498};
GN ORFNames=M513_03173 {ECO:0000313|EMBL:KFD56049.1}, M514_03173
GN {ECO:0000313|EMBL:KFD65995.1};
OS Trichuris suis (pig whipworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichuridae; Trichuris.
OX NCBI_TaxID=68888 {ECO:0000313|EMBL:KFD65995.1};
RN [1] {ECO:0000313|EMBL:KFD65995.1, ECO:0000313|Proteomes:UP000030764}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DCEP-RM93F {ECO:0000313|EMBL:KFD65995.1}, and DCEP-RM93M
RC {ECO:0000313|EMBL:KFD56049.1};
RX PubMed=24929829; DOI=10.1038/ng.3012;
RA Jex A.R., Nejsum P., Schwarz E.M., Hu L., Young N.D., Hall R.S.,
RA Korhonen P.K., Liao S., Thamsborg S., Xia J., Xu P., Wang S.,
RA Scheerlinck J.P., Hofmann A., Sternberg P.W., Wang J., Gasser R.B.;
RT "Genome and transcriptome of the porcine whipworm Trichuris suis.";
RL Nat. Genet. 46:701-706(2014).
CC -!- COFACTOR:
CC Name=Cu(2+); Xref=ChEBI:CHEBI:29036;
CC Evidence={ECO:0000256|ARBA:ARBA00001973};
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DR EMBL; KL363196; KFD56049.1; -; Genomic_DNA.
DR EMBL; KL367529; KFD65995.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A085N949; -.
DR Proteomes; UP000030758; Unassembled WGS sequence.
DR Proteomes; UP000030764; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR Gene3D; 1.10.1280.10; Di-copper center containing domain from catechol oxidase; 1.
DR InterPro; IPR008922; Di-copper_centre_dom_sf.
DR InterPro; IPR002227; Tyrosinase_Cu-bd.
DR PANTHER; PTHR11474:SF124; TYROSINASE; 1.
DR PANTHER; PTHR11474; TYROSINASE FAMILY MEMBER; 1.
DR Pfam; PF00264; Tyrosinase; 1.
DR PRINTS; PR00092; TYROSINASE.
DR SUPFAM; SSF48056; Di-copper centre-containing domain; 1.
DR PROSITE; PS00497; TYROSINASE_1; 1.
DR PROSITE; PS00498; TYROSINASE_2; 1.
PE 4: Predicted;
KW Copper {ECO:0000256|ARBA:ARBA00023008};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..467
FT /note="Tyrosinase copper-binding domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010405358"
FT DOMAIN 185..202
FT /note="Tyrosinase copper-binding"
FT /evidence="ECO:0000259|PROSITE:PS00497"
FT DOMAIN 340..351
FT /note="Tyrosinase copper-binding"
FT /evidence="ECO:0000259|PROSITE:PS00498"
SQ SEQUENCE 467 AA; 53315 MW; 60B758715FFAAC7B CRC64;
MNSAALWVLF LRLLIGSNGA APPHMDRNPV GNLWSVEADL FKYINTTANE CVRKIRSSGN
ANFQYRLSET QCGYYCISNL PWYNEVENPE DPADYMEENE HAAFKKLCAC RDLQNCLQFD
QKDVSWRKKR QAQTPALRKE YRTLTEEERT RFHVAINQLK SGTGQPISYD TFVEMHQADR
APGAHIGAAF LPWHREYLRL FETALRSIDP SIGLPYFDTT LDDPLPTPRD SIMWSEEFLG
NGNGDVVTGS FANWMATDGK KLNRAVGRSG AGSLFRPSDI QYILDRPDFA HLTECIDPFF
ETASLFRMIA TILIWRFQIH GSVHTWIGGQ MSVVPYSPND PVFWLHHAFI DKVWEQYRQT
RQTPEQRETS YPTGNATCTA AHRADSRMLP FTILNIDGMS NEYTRIFYKY QDSPTCSHAN
PTCGSPYLFC DTRFYRCVSK VVKGGDCGGY EGLDVCYKSN CVNTRCV
//
