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Database: UniProt
Entry: A0A085NCL3_9BILA
LinkDB: A0A085NCL3_9BILA
Original site: A0A085NCL3_9BILA 
ID   A0A085NCL3_9BILA        Unreviewed;      1607 AA.
AC   A0A085NCL3;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   31-JUL-2019, entry version 23.
DE   RecName: Full=Receptor protein serine/threonine kinase {ECO:0000256|SAAS:SAAS00138132};
DE            EC=2.7.11.30 {ECO:0000256|SAAS:SAAS00138132};
GN   ORFNames=M514_07574 {ECO:0000313|EMBL:KFD67209.1};
OS   Trichuris suis (pig whipworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC   Trichinellida; Trichuridae; Trichuris.
OX   NCBI_TaxID=68888 {ECO:0000313|EMBL:KFD67209.1};
RN   [1] {ECO:0000313|EMBL:KFD67209.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DCEP-RM93F {ECO:0000313|EMBL:KFD67209.1};
RX   PubMed=24929829; DOI=10.1038/ng.3012;
RA   Jex A.R., Nejsum P., Schwarz E.M., Hu L., Young N.D., Hall R.S.,
RA   Korhonen P.K., Liao S., Thamsborg S., Xia J., Xu P., Wang S.,
RA   Scheerlinck J.P., Hofmann A., Sternberg P.W., Wang J., Gasser R.B.;
RT   "Genome and transcriptome of the porcine whipworm Trichuris suis.";
RL   Nat. Genet. 46:701-706(2014).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[receptor-protein]-L-serine + ATP = [receptor-protein]-O-
CC         phospho-L-serine + ADP + H(+); Xref=Rhea:RHEA:18673, Rhea:RHEA-
CC         COMP:11022, Rhea:RHEA-COMP:11023, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421,
CC         ChEBI:CHEBI:456216; EC=2.7.11.30;
CC         Evidence={ECO:0000256|SAAS:SAAS01128400};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[receptor-protein]-L-threonine + ATP = [receptor-
CC         protein]-O-phospho-L-threonine + ADP + H(+);
CC         Xref=Rhea:RHEA:44880, Rhea:RHEA-COMP:11024, Rhea:RHEA-
CC         COMP:11025, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC         EC=2.7.11.30; Evidence={ECO:0000256|SAAS:SAAS01128404};
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. TKL Ser/Thr
CC       protein kinase family. TGFB receptor subfamily.
CC       {ECO:0000256|SAAS:SAAS00595019}.
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DR   EMBL; KL367517; KFD67209.1; -; Genomic_DNA.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004525; F:ribonuclease III activity; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004675; F:transmembrane receptor protein serine/threonine kinase activity; IEA:InterPro.
DR   GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR   GO; GO:0016075; P:rRNA catabolic process; IEA:InterPro.
DR   CDD; cd00048; DSRM; 1.
DR   CDD; cd00593; RIBOc; 2.
DR   Gene3D; 1.10.1520.10; -; 1.
DR   HAMAP; MF_00104; RNase_III; 1.
DR   InterPro; IPR000472; Activin_recp.
DR   InterPro; IPR014720; dsRBD_dom.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR011907; RNase_III.
DR   InterPro; IPR000999; RNase_III_dom.
DR   InterPro; IPR036389; RNase_III_sf.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   InterPro; IPR000333; TGFB_receptor.
DR   PANTHER; PTHR23255; PTHR23255; 2.
DR   Pfam; PF01064; Activin_recp; 1.
DR   Pfam; PF00035; dsrm; 1.
DR   Pfam; PF00069; Pkinase; 1.
DR   Pfam; PF14622; Ribonucleas_3_3; 1.
DR   Pfam; PF00636; Ribonuclease_3; 1.
DR   SMART; SM00358; DSRM; 1.
DR   SMART; SM00535; RIBOc; 2.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   SUPFAM; SSF69065; SSF69065; 2.
DR   PROSITE; PS50137; DS_RBD; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR   PROSITE; PS00517; RNASE_3_1; 1.
DR   PROSITE; PS50142; RNASE_3_2; 2.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|SAAS:SAAS00138218};
KW   Kinase {ECO:0000256|SAAS:SAAS00138139};
KW   Membrane {ECO:0000256|SAAS:SAAS00138203};
KW   Nucleotide-binding {ECO:0000256|SAAS:SAAS00138212};
KW   Receptor {ECO:0000256|SAAS:SAAS00138179};
KW   RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00266};
KW   Serine/threonine-protein kinase {ECO:0000256|SAAS:SAAS00138186};
KW   Transferase {ECO:0000256|SAAS:SAAS00138167};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00138220};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00488859}.
FT   DOMAIN      185    477       Protein kinase. {ECO:0000259|PROSITE:
FT                                PS50011}.
FT   DOMAIN     1029   1213       RNase III. {ECO:0000259|PROSITE:PS50142}.
FT   DOMAIN     1267   1399       RNase III. {ECO:0000259|PROSITE:PS50142}.
FT   DOMAIN     1426   1501       DRBM. {ECO:0000259|PROSITE:PS50137}.
FT   REGION      637    668       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COMPBIAS    637    660       Polar. {ECO:0000256|SAM:MobiDB-lite}.
SQ   SEQUENCE   1607 AA;  181657 MW;  DF59D9D335AD428B CRC64;
     MRVACISEEL FIDRMSDDAS AVCSNVRMWK CFQGNISSSF SSLFRTALIS LTANMDTTSL
     HGVDFTCSAY LANQCNKTVA ECETEENCSH LGPSQYGCYA VWKYIADEVN VLYKGCWTNQ
     NGCDSGKCVA TGPSTDAGVG STEVYFCCCN QPMCNRHFQL AFDSLPITST ETTPSMTSTN
     FFNNLPFLEM VSRGHYGSVW RATMGTQTVA VKIFQAQHID SWVQEQEIYG VAGLKSHPNV
     LSFVGAEVRG SDPRMEYWII TAFHVNGSLH DYLKKKTVTF NELLRIAVSM LRGLSYLHEE
     ILNNDKSYKP TIVHRDFKSR NVLLKDDLVA CVADFGLALV CEHGRTPNET HGQVGTRRYM
     APEVLEGATE FSAFAFRQID VYAAALVLWE LLSRCGFKNV EPGEYMLPFE AEVGLRPSLQ
     EIQEIAVIKK RRPILKAVWR EDPHAAVVCS AIEEMWDNEP EARISAGCAA ERLDALVSVA
     GDHSAEQSKG ELTPLIVRQE KDTFCNVQSF DVKLNGAMSL CEIGLSEFDF RDCEPLPEPP
     EGRNPRNRSI KDVKHTLRLV KDDKYYLSCN VGSSADKQER IVGATSKLIG LHRAFKEKLL
     DVYERARKSH ASSASVAQSS GLDRAYKHTA KCCLFSDHSS SSSSSGEASD SGSTSGSDSS
     RRRAIYRKQS HPARLHPDLW FNERGEMNDG PVCRCCWKAR QRGVAHYIFA GEKPIEACDP
     LTNNRNRLYY YKLSVSPDIN LTKEYSTTKI MYEGREFTFD GYGILCHSEV PTTIPDRLMI
     RWNIEYKLSL EKEPFPEYFT AEDCCLFWQY FFVDLMELYD VNLLPSGSCD GCPTFHVIPR
     FVVKNSDNSI ELLPMSAVLE HLLRSYEPVF CPNAFASGAQ WNDLVANLKG QLVSNPFKRP
     SSLRLDQIDR TAVVPDCVDG CYPVIVHFGV RPAVMTYNGN PEYQREYRKF LKFCRLIQLK
     PSTSSEDKNK MAEWKENLKI MKDKVSATRD VTIELSSKGF YKTGIYSDMV QHGLKLIVMF
     HHIRFHLSLR VLEQRLQYSF NDRALLELAL THPSYRPNYA TNADHIRNTL SNCGLPFLFA
     YMAIAEYVAA FHGDMFAGIQ KLMEVMSQMG CKTAKESEAM NNERLEFLGD AVIEFLTTIH
     LYYMFSDLEE GGLATFRSTL VQNNHLAVLA RKIGLDEFML YVHGPDLCHE EDLKHAMANA
     FEALLGALFL DGGIAVTDRV YGCTLFPAEE DEDLHWIWFN PPLHPLQAEE PNGDRHLVDG
     IEILRNLTEF EDQIGIKFTH IRLLARAFTR KSRSRALTVD AFCRGHNQRM EFLGDTVLQL
     ITSEYLYKYF PTHQEGHLSL LRSCLVSNKT QAVICDDIGI PKFVNPPVPI LANNSYDLRT
     KDKADLVESF LGALFVDKGL EYCKLFCQLC FIPRLKHFIL NQKWSDPKTR LQQSCIALRD
     PSGGEPEIPQ YKVVSVEGPT NTRVYKVAVY FRNSRLAVGY GQSIKDAEID AAETALHTKA
     DMLPKILRRE TCKAPKAREA SDLDVEKRKK VCSCMLHVHI NPMYSLPTAL LMTSRRSCRE
     VECALIEGTA LFVANPRRAV HGFRKVFNMQ LIQFQLAIRS LMGLRMG
//
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