ID A0A085NDA9_9BILA Unreviewed; 1816 AA.
AC A0A085NDA9;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=Chloride channel protein {ECO:0000256|RuleBase:RU361221};
GN ORFNames=M514_00558 {ECO:0000313|EMBL:KFD67455.1};
OS Trichuris suis (pig whipworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichuridae; Trichuris.
OX NCBI_TaxID=68888 {ECO:0000313|EMBL:KFD67455.1};
RN [1] {ECO:0000313|EMBL:KFD67455.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DCEP-RM93F {ECO:0000313|EMBL:KFD67455.1};
RX PubMed=24929829; DOI=10.1038/ng.3012;
RA Jex A.R., Nejsum P., Schwarz E.M., Hu L., Young N.D., Hall R.S.,
RA Korhonen P.K., Liao S., Thamsborg S., Xia J., Xu P., Wang S.,
RA Scheerlinck J.P., Hofmann A., Sternberg P.W., Wang J., Gasser R.B.;
RT "Genome and transcriptome of the porcine whipworm Trichuris suis.";
RL Nat. Genet. 46:701-706(2014).
CC -!- SUBCELLULAR LOCATION: Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004337}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004337}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU361221}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU361221}.
CC -!- SIMILARITY: Belongs to the chloride channel (TC 2.A.49) family.
CC {ECO:0000256|RuleBase:RU361221}.
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DR EMBL; KL367514; KFD67455.1; -; Genomic_DNA.
DR SMR; A0A085NDA9; -.
DR Proteomes; UP000030758; Unassembled WGS sequence.
DR GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:UniProtKB-UniRule.
DR CDD; cd04591; CBS_pair_voltage-gated_CLC_euk_bac; 1.
DR CDD; cd03684; ClC_3_like; 1.
DR Gene3D; 3.10.580.20; -; 1.
DR Gene3D; 3.90.1280.20; -; 1.
DR Gene3D; 1.10.3080.10; Clc chloride channel; 1.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR014743; Cl-channel_core.
DR InterPro; IPR001807; Cl-channel_volt-gated.
DR InterPro; IPR031437; TMEM132_M.
DR PANTHER; PTHR45711; CHLORIDE CHANNEL PROTEIN; 1.
DR PANTHER; PTHR45711:SF6; CHLORIDE CHANNEL PROTEIN; 1.
DR Pfam; PF00571; CBS; 2.
DR Pfam; PF16070; TMEM132; 1.
DR Pfam; PF00654; Voltage_CLC; 1.
DR PRINTS; PR00762; CLCHANNEL.
DR SMART; SM00116; CBS; 2.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR SUPFAM; SSF81340; Clc chloride channel; 1.
DR PROSITE; PS51371; CBS; 2.
PE 3: Inferred from homology;
KW CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703};
KW Chloride {ECO:0000256|ARBA:ARBA00023214, ECO:0000256|RuleBase:RU361221};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Ion transport {ECO:0000256|RuleBase:RU361221};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361221};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361221};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361221}; Transport {ECO:0000256|RuleBase:RU361221}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..1816
FT /note="Chloride channel protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5001795910"
FT TRANSMEM 855..877
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 1117..1148
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 1212..1237
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 1258..1280
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 1314..1338
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 1350..1367
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 1388..1409
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 1494..1514
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 1520..1540
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 1586..1613
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT DOMAIN 1654..1718
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT DOMAIN 1749..1810
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT REGION 933..956
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1816 AA; 201623 MW; 9CA77E6082C727F2 CRC64;
MSSGLFLFLI VGFSSIPRIL IDAMSINFSK QDRVFILKTL SPKSVDVRNI INPFDDPDEE
IVHENIWVAE DDFSDTRVLM SDAGLNVEES IDTLSNVPLP VVTVRPLSHT VGREQPSIRL
IVHQATDLQS VYHREETRSI LCVTVFLLFR DQYIAQRCSP GSDLNICAVD MLVPLSWWSK
DDLQSTVTPS GSKKPKRNVK VGFSVRATSG TTNNCSKLTE ERARSRISAG SDSLKRVHWT
DNELEMIHVS EYTLLPIDGT LSMLVPNLKF YPGTIFTIAI KFQHRPEELN RFIQSFKLRC
QASPNLSFHS VEKIPDGSWS VVSSIELRQR ILDVSAFYTG NMPKNESLSS EVVIMTVSVS
KDDKAAEELS ELLWTVEYTF LVNDANSPDR SVEQNREEKT NERTLNTRFT MQKDSLMGLF
TLGKSNLINT AIMSGRQVSA AVKVCSVTYA GIVSEVTLSS TCFSVEPSVL KVTPSCTAVY
VDGTESRGSA NAAIEIEFGE IKTRALFSVW YPEMPLSLLL AKPGVNYFSD RRFSNGTNPE
NHQSSFFCRS RYQESQIKVF GRFRVDNPQS GWHAYLGTRG RQVLFDLTDL TKEHLKVTDS
RVANLYHSPT GNVYVQGLSV GYTDIHVLSP FSRLPYGATE VQVTNELVSI RKVAVHSLCA
MSGEISASDF WNNVYKLSVT KTRTFFKRLQ ECFLNIVLEY SDGTKTALSE LPHADFEASV
ETSDGSLLIL ESDSFSSATF RYLVMDELRE GTIRVKVAGP QRCLLESSTG EENSLGRASV
IVKPQKRSAT VRANDADDPS KHLSSAFIGT YGLSGMHKRM KAISLDQSRL QSDKPGMNSD
VHSESTANYS RPPEIVMYCM IAVCAIVGAI FSLNCLVRST GPKLAVLNPS CFRVANLTST
SALFSIFRRD EVMPAGEEFI WVKADRFSHP NAHSFNQANG RSSDSGGGPC SSNMRNSCIH
TTTERKHGRR AGGSYMGSEV SIHMSDHPVI EVHEDGRRAS SWNIARSRSR QHALVDSSSE
RNISQYTSNP SAELHWNSRS LGLNEVQLQN FINSLRETIT IMFSTGCSGN ALGGDGDEPF
TVGIGQYDDF HTIDWQRDLT RDRLRHKFIK KKSHESICNA ISSVIDAGSG WICVLFVGIA
AGCVAGIVDI STKWMSNLKE GVCPDAFWFD KVHCCWSAND TFFSGDKCSA WHTWPELLGH
YEVDALAFFV EYVFYVFWAI CMTGLAVVLV RVFAPYACGS GIPEIKCILS GFIIRGYLGK
WTLLIKSVGL ALAAASGLSL GKEGPMVHLA CCIGNIFSYL FPKYGKNEAK KREILSASAA
AGVSVAFGAP IGGVLFSLEE ASYYFPLKTL WRSFFCALIA GLVLKFINPF GTEQTSLFAV
DYPMKWSYIE LIPFILLGTF GGIVGTIFIK GNVRWCRMRR NSKLGQYPVA EVFGVTLITA
VLSFPSEYTR KSSSDLIQQL FNRCGPEDVS ELCSYKRNAE SSEDPFEPAL YSCIWKLIVV
LVFKIVITIF TFGIKVPSGL FVPSLAIGAI GGRLVGIAME RIAFTNKEAW WWGLHCERGR
TCVEPGMYAM ATIDLLFTLF ENRFFLVSLV VIMFELTGSL EFIVPTMAAV MFAKWVGDAL
ERKGIYDAHI ALNGYPFLDN KEEFIHNTVA ADVMRPRPGD PPLRVIPQEG MTVGDIEELL
RCTRHNGFPV VVSMDHANLL GFVTRRDLSL AIASARKTQE GVVTDSNVYF SAVAPAAPEG
PGYPMPLKLR KLLDLAPISI TDQTPMETVI DIFRKLGLRQ LLVTHMGKLL GIVTKKDVLK
HINQLENDDS YAILYS
//
