ID   A0A085NK84_9BILA        Unreviewed;       844 AA.
AC   A0A085NK84;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   27-MAR-2024, entry version 45.
DE   RecName: Full=SET domain protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=M514_06105 {ECO:0000313|EMBL:KFD69880.1};
OS   Trichuris suis (pig whipworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC   Trichinellida; Trichuridae; Trichuris.
OX   NCBI_TaxID=68888 {ECO:0000313|EMBL:KFD69880.1};
RN   [1] {ECO:0000313|EMBL:KFD69880.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DCEP-RM93F {ECO:0000313|EMBL:KFD69880.1};
RX   PubMed=24929829; DOI=10.1038/ng.3012;
RA   Jex A.R., Nejsum P., Schwarz E.M., Hu L., Young N.D., Hall R.S.,
RA   Korhonen P.K., Liao S., Thamsborg S., Xia J., Xu P., Wang S.,
RA   Scheerlinck J.P., Hofmann A., Sternberg P.W., Wang J., Gasser R.B.;
RT   "Genome and transcriptome of the porcine whipworm Trichuris suis.";
RL   Nat. Genet. 46:701-706(2014).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; KL367492; KFD69880.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A085NK84; -.
DR   Proteomes; UP000030758; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0042054; F:histone methyltransferase activity; IEA:InterPro.
DR   Gene3D; 2.170.270.10; SET domain; 1.
DR   InterPro; IPR006560; AWS_dom.
DR   InterPro; IPR003616; Post-SET_dom.
DR   InterPro; IPR001214; SET_dom.
DR   InterPro; IPR046341; SET_dom_sf.
DR   PANTHER; PTHR22884:SF413; HISTONE-LYSINE N-METHYLTRANSFERASE CG1716-RELATED; 1.
DR   PANTHER; PTHR22884; SET DOMAIN PROTEINS; 1.
DR   Pfam; PF17907; AWS; 1.
DR   Pfam; PF00856; SET; 1.
DR   SMART; SM00570; AWS; 1.
DR   SMART; SM00317; SET; 1.
DR   SUPFAM; SSF82199; SET domain; 1.
DR   PROSITE; PS51215; AWS; 1.
DR   PROSITE; PS50868; POST_SET; 1.
DR   PROSITE; PS50280; SET; 1.
PE   4: Predicted;
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          29..72
FT                   /note="AWS"
FT                   /evidence="ECO:0000259|PROSITE:PS51215"
FT   DOMAIN          74..191
FT                   /note="SET"
FT                   /evidence="ECO:0000259|PROSITE:PS50280"
FT   DOMAIN          198..214
FT                   /note="Post-SET"
FT                   /evidence="ECO:0000259|PROSITE:PS50868"
FT   REGION          365..384
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          418..438
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          451..472
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          480..499
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          721..740
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        418..436
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        451..469
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        722..739
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   844 AA;  96520 MW;  D346FD0A0D36B047 CRC64;
     MDARLSESLS FTQITENVYV SDNQKSRDSN VYDCDCDHPC DEQCLNYSME IECGNECSWG
     DQCKNRRFQR KEYKKLDVFA AGRKGLGIRA AERIQDLSFI IEYVGEVLSG DALLERVQRY
     DVNGVKHRYM MSLDNGDVID ATVKGNLSRL INHSCDPNCI VRKWMVLGRT RAGIFALRDI
     EIGEELSFDY QFDVHEMSMQ VCYCGAANCR GVLASVRSLN KSQERPAASQ LTVFRRLNTK
     EEQLLLTLTK KGSLKTFSDA VQCTGLMRRT EDLNQRLQLA ELIMNSRDQV RRDFLSPSSC
     IILRHWMTDV LDCYDKVDEY VLKMLDLLNS LPFPHKTMLE KSSLLEELGK WTNVDFLKQL
     LSQKKSEEHS ESAQEDEQNA SHPLANVDVI AKRAEEMLNS WLLLKNEYKI PRLRIEKEKP
     SSCSEQAEKR RSDNYSSNRI VDNSISDFSV LKRPSVGSPG SSLSPPSGWS PTHELRAREF
     AQDDSCRSGD VVPRSTKKYH GRRSVEINAN IYDRALSEER QPKTPADLNY NNVAQLNGSR
     CEKLELAKPA SKANQPVLPM FPYTEGAMVN YLAPNQGNFV LHQENQNAWP YYAWYPNICQ
     MPNVEVNSFC NFERASFLCL QASENLFCEA QLQSDWRYQG PLCSLEVAEQ LGNSLLDDKM
     KKLSILISIF TFLELEQRAL IGSRIELLEI QEKSSVRSPV QQMYTYIPVL PIFEAPKGPP
     VYSPTDSSNH FSSSPQPDQW EEERYCDPIS LRADFKKEMA SMVVSMVEKY ATSTDVPRLS
     KTQFKRFARC LTKMIGEKYL SIVLSSGNKK IFREVGKKAS VFVAKMLRNG FYEKFNKTIP
     TNRP
//