ID A0A085NMJ6_9BILA Unreviewed; 1596 AA.
AC A0A085NMJ6;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:KFD70692.1};
GN ORFNames=M514_10441 {ECO:0000313|EMBL:KFD70692.1};
OS Trichuris suis (pig whipworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichuridae; Trichuris.
OX NCBI_TaxID=68888 {ECO:0000313|EMBL:KFD70692.1};
RN [1] {ECO:0000313|EMBL:KFD70692.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DCEP-RM93F {ECO:0000313|EMBL:KFD70692.1};
RX PubMed=24929829; DOI=10.1038/ng.3012;
RA Jex A.R., Nejsum P., Schwarz E.M., Hu L., Young N.D., Hall R.S.,
RA Korhonen P.K., Liao S., Thamsborg S., Xia J., Xu P., Wang S.,
RA Scheerlinck J.P., Hofmann A., Sternberg P.W., Wang J., Gasser R.B.;
RT "Genome and transcriptome of the porcine whipworm Trichuris suis.";
RL Nat. Genet. 46:701-706(2014).
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CutA family.
CC {ECO:0000256|ARBA:ARBA00010169}.
CC -!- SIMILARITY: Belongs to the methyltransferase superfamily. NTM1 family.
CC {ECO:0000256|ARBA:ARBA00009059}.
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DR EMBL; KL367486; KFD70692.1; -; Genomic_DNA.
DR Proteomes; UP000030758; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0140042; P:lipid droplet formation; IEA:UniProt.
DR GO; GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0010038; P:response to metal ion; IEA:InterPro.
DR GO; GO:0006986; P:response to unfolded protein; IEA:InterPro.
DR CDD; cd02440; AdoMet_MTases; 1.
DR CDD; cd17399; MFS_MFSD7; 1.
DR Gene3D; 3.30.70.120; -; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR004323; Ion_tolerance_CutA.
DR InterPro; IPR008485; JAMP.
DR InterPro; IPR008576; MeTrfase_NTM1.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR011322; N-reg_PII-like_a/b.
DR InterPro; IPR015867; N-reg_PII/ATP_PRibTrfase_C.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR009617; Seipin.
DR InterPro; IPR049680; SLC49-like.
DR PANTHER; PTHR10924; MAJOR FACILITATOR SUPERFAMILY PROTEIN-RELATED; 1.
DR PANTHER; PTHR10924:SF6; SOLUTE CARRIER FAMILY 49 MEMBER A3; 1.
DR Pfam; PF03091; CutA1; 1.
DR Pfam; PF05571; JAMP; 1.
DR Pfam; PF05891; Methyltransf_PK; 1.
DR Pfam; PF07690; MFS_1; 1.
DR Pfam; PF06775; Seipin; 1.
DR SUPFAM; SSF54913; GlnB-like; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 689..707
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 727..747
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 754..772
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 784..808
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 851..872
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 905..927
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 939..962
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 974..991
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 997..1016
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1036..1055
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1084..1104
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1375..1395
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1407..1429
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1478..1499
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1519..1552
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1573..1593
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 1596 AA; 177456 MW; A68C6DC473AF6F88 CRC64;
MRLASRGVFS VAYVTVPNEE VAKKLARSLV EKKLAACVNV IPGLKSIYEW KGAIEEDSEL
LLMIKTRTSM IEELSAYVRA NHPYSVAEVI ALPVIVPSKV FSLDLPFLSE ADDCSVYFAF
SLLLSCILTV PQCFGQMDDA DSEYKAAEEY WKAIQPNVKG MLGGLDKLSG IDITGSRQFL
DKVVAKLNLR KRYALDCGCG IGRVTKAVLS RVFAQIDMVD VTKEFLDASA DYMGFRVNGK
VVEKFCCGLQ HFVPPANRYD LIWIQWVSGQ LTDNDLKQFL LRCKMNCWSY CGNLKNYAGS
MPAALDQTIH FVLSGKQLQQ SCSAPVHTAK ESVCGYEWYV ECRKSEQQNE IELLLLAVPC
DDCDAFELLV DYEMTACVDN VRAKLVVDCE IINSRYISEE DCSPVLRVSG ICCVLEQTKD
CSLSVRIVVR ELLTVRRDDL TVETDQDNFM FLAATKVFYV NLRYLASFGS IKFNDLLERS
KRGLRRIVVL SASPEELDIF LSALCRYGRP VITSRNWLTV LSLSLEFGVD SLVRLCEAFL
INAKGIHVVR KLEYSLEYKL PYLTSTVVRQ IQNDELTALE LLHQYLESNS EELSQMDPAV
LKAFGENFPA PWKSLNCICK GMKRLRALFS SALSGRSEEA DQAVPMATDA VYCPPVVVVD
EAEPCRDKEF SPVSVADGAE VLKSYKRRWF VLLVISLLNA SNTMSWIAYA PVANFVDTYY
GKQTSNFLSF TFILWAIPVG FLAIWSAGRF GLRLAVFLAS WFNFVGAVLR ILSCVPDLSQ
QGRFAMVVLG QCVAACCYPF IMFLPTKVAA DWFPPSQRTI ANVIATLCNP VGILIANFMS
PKLVVDLSGI VLLHGVLVLP AALVCLMTSI GIRTSTPPLP PSHSAAAESL SFKLGLRKAF
RSRTYLLLLL ALGTGIGTFN TLYTVMQQLL CSRGYGNEFA GLCCVLMNVS GLVGSVLVGY
FVDRTKLFVE TIKVAFCLAV LSGISFTMVS LQYNLPAAVI GCAMAFGFFG VAVYPLGFEM
GAECMFPVAE TTSAGLITFA GQLGSITFIP IMQFLSSPMK GAASKWQVCT APDEADVPAY
DMTLPMMLMV GLSSIVACIF VICFRPKYRR MNVDRQGKVV VEQNAVRVAP REGILEIKTV
FVSAWLVPDL SVRSFPANFI FKTCFGVGAC SFPTANVSTV VEKESSIVRG LTYDVWLDLT
VFPDGEARTA GMFMLVSKCH DYSGFVWYES KRSGTLTFSS TLVRWCRLAY RLPWILLGFI
NEEERVVLHL LDNLVVHRQN DCRMLQVEIQ SNKLTISKAS VRFVPRVRCG RVIIFVLHPN
PTMVHTFPRC PGDYCGRTMD ASGNLSDCGA CEWGTRADQR DICVRCELEP TMYHWLYLNF
MAFLPFLHHC AFAAMTMSRK QLSSSVIGSQ ILASAIECVL AGLASLLMVD PFGSLHFRTC
GVKRMADWYT VFYNPVIDYT ETIYCTQEAV YPLYFLPFLY YLLSLVAMIF VRPAVLYAFN
VKKDDVSDAI YAALYLYPAL IVLHAVLCGI IYSAFPFVLL FAAICLNAIH LALYPEQSAK
AILKSAWQSR QNLASAITLL LIYTDAILSI SALPTL
//
