ID A0A085NML4_9BILA Unreviewed; 903 AA.
AC A0A085NML4;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 24-JAN-2024, entry version 39.
DE RecName: Full=Delta-like protein {ECO:0000256|RuleBase:RU280815};
DE Flags: Fragment;
GN ORFNames=M514_06056 {ECO:0000313|EMBL:KFD70710.1};
OS Trichuris suis (pig whipworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichuridae; Trichuris.
OX NCBI_TaxID=68888 {ECO:0000313|EMBL:KFD70710.1};
RN [1] {ECO:0000313|EMBL:KFD70710.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DCEP-RM93F {ECO:0000313|EMBL:KFD70710.1};
RX PubMed=24929829; DOI=10.1038/ng.3012;
RA Jex A.R., Nejsum P., Schwarz E.M., Hu L., Young N.D., Hall R.S.,
RA Korhonen P.K., Liao S., Thamsborg S., Xia J., Xu P., Wang S.,
RA Scheerlinck J.P., Hofmann A., Sternberg P.W., Wang J., Gasser R.B.;
RT "Genome and transcriptome of the porcine whipworm Trichuris suis.";
RL Nat. Genet. 46:701-706(2014).
CC -!- FUNCTION: Putative Notch ligand involved in the mediation of Notch
CC signaling. {ECO:0000256|RuleBase:RU280815}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU280815}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU280815}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KL367486; KFD70710.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A085NML4; -.
DR Proteomes; UP000030758; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0032502; P:developmental process; IEA:UniProt.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 6.
DR Gene3D; 2.10.25.140; -; 1.
DR Gene3D; 2.60.40.3510; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 8.
DR InterPro; IPR001774; DSL.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR011651; Notch_ligand_N.
DR PANTHER; PTHR24049; CRUMBS FAMILY MEMBER; 1.
DR PANTHER; PTHR24049:SF22; DROSOPHILA CRUMBS HOMOLOG; 1.
DR Pfam; PF21700; DL-JAG_EGF-like; 1.
DR Pfam; PF01414; DSL; 1.
DR Pfam; PF00008; EGF; 5.
DR Pfam; PF12661; hEGF; 2.
DR Pfam; PF07657; MNNL; 1.
DR SMART; SM00051; DSL; 1.
DR SMART; SM00181; EGF; 9.
DR SMART; SM00179; EGF_CA; 7.
DR SUPFAM; SSF57196; EGF/Laminin; 7.
DR PROSITE; PS00010; ASX_HYDROXYL; 2.
DR PROSITE; PS51051; DSL; 1.
DR PROSITE; PS00022; EGF_1; 7.
DR PROSITE; PS01186; EGF_2; 5.
DR PROSITE; PS50026; EGF_3; 7.
DR PROSITE; PS01187; EGF_CA; 2.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW ECO:0000256|RuleBase:RU280815};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW Membrane {ECO:0000256|RuleBase:RU280815, ECO:0000256|SAM:Phobius};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU280815};
KW Signal {ECO:0000256|RuleBase:RU280815};
KW Transmembrane {ECO:0000256|RuleBase:RU280815, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|RuleBase:RU280815,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 668..693
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 246..290
FT /note="DSL"
FT /evidence="ECO:0000259|PROSITE:PS51051"
FT DOMAIN 355..393
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 395..431
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 433..472
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 474..510
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 512..548
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 550..586
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 588..625
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 828..859
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 248..257
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 261..273
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 281..290
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 383..392
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 421..430
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 462..471
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 500..509
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 538..547
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 576..585
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 615..624
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFD70710.1"
SQ SEQUENCE 903 AA; 98494 MW; 231DC1769DE1F392 CRC64;
IFATSDLPHC RLQGANHGIL SQAKRISGQS RPLPFLDGLL NRRSAVSWST SMQVLLLRLV
GAFLLMARMS RSLGTLEFRI NSFQNYDALD ADGVCCKAAT PGPSTKSVCS PVCNLVFRVC
LETERTNVQT NPSCTLGGWL MSSIDSGREY LSLLRQSDRV TATSSVMKHA VNYRWPGKLI
MTVEIWHQPN GSSSTQLHAL GTDYAVATDR QLLLRVAERK RLPVSGRWNV EEYSNAHSRL
RLQLRFVCSE HYYGPQCETF CSSRNDSGGH YSCDKDGTKI CMLGWQGPKC KDAVCKKGCK
YGTCERPGDC VCISGYVGID CDVCKRYPGC MHGTCSKPFE CTCLKGWGGV FCNQDLNFCV
NKKPCQNGGV CSNSGSGSYT CACAPGYSGT NCELKVETCQ MNPCQNGGTC HESGANYTCS
CAANFSGRHC QTNAQTCKEK PCENDAICVD DSPSQLGYRC LCKPGWEGTN CDTERDECRS
EPCMNGGSCV TKFGGFHCVC PVGFVGDRCE SNVDDCPENA CLNGGTCEDE VNNFRCHCPQ
GFMGTLCQTN IDDCLKRPCL NGGSCIDLVN DFACVCPPGY KGKDCSVRLG GCDANPCLNG
GTCRNVHHRD YVCQCPPCTA GRNCHIRNQD CPWNGTFKPY ITSPPVAISD GGRQLVDELR
TSVSEIPMLV GAPLGGALVL LIVALFFIAC LMYRKGKRSS RAASPAVIKN NLKAYQQQNH
WNEWNLCKDS AAKGYAISKD VDFSSPYSAL EAKGLSEEKE DVYTGKVFGS SAKPYSIKQG
RNINQYETFV GVYPLRGTRR KCDTANMPKQ YCNAADDEQD HHYGCASAME PGERSSSPTY
KSTECAVPVP PKKPAPLLPA GDRMLSHVSV DAQRLEAMSH GDTATYESQL CTEPCDTNRV
SQV
//