ID A0A085NP04_9BILA Unreviewed; 970 AA.
AC A0A085NP04;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 13-SEP-2023, entry version 25.
DE RecName: Full=PH domain protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=M514_04954 {ECO:0000313|EMBL:KFD71200.1};
OS Trichuris suis (pig whipworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichuridae; Trichuris.
OX NCBI_TaxID=68888 {ECO:0000313|EMBL:KFD71200.1};
RN [1] {ECO:0000313|EMBL:KFD71200.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DCEP-RM93F {ECO:0000313|EMBL:KFD71200.1};
RX PubMed=24929829; DOI=10.1038/ng.3012;
RA Jex A.R., Nejsum P., Schwarz E.M., Hu L., Young N.D., Hall R.S.,
RA Korhonen P.K., Liao S., Thamsborg S., Xia J., Xu P., Wang S.,
RA Scheerlinck J.P., Hofmann A., Sternberg P.W., Wang J., Gasser R.B.;
RT "Genome and transcriptome of the porcine whipworm Trichuris suis.";
RL Nat. Genet. 46:701-706(2014).
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DR EMBL; KL367483; KFD71200.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A085NP04; -.
DR Proteomes; UP000030758; Unassembled WGS sequence.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd01259; PH_APBB1IP; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR039664; GRB/APBB1IP.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR039665; PH_APBB1IP.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR11243; GROWTH FACTOR RECEPTOR-BOUND PROTEIN; 1.
DR PANTHER; PTHR11243:SF23; LD06925P; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00788; RA; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00314; RA; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50200; RA; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils}.
FT DOMAIN 316..402
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT DOMAIN 446..556
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 103..129
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 192..265
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 786..823
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 878..905
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 270..301
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 200..265
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 970 AA; 106729 MW; 221C5568C008F9C3 CRC64;
MKNESIIGEV MLAKQVRHCL PAHLNNSATC SQLCAVPEGK SKFPARASSC CEDVYGDDGE
LDSDAEADLD PDAQLGRWLD QLQVLSDGLA GVCSGAAGNM NSSFSPPRGL DAKVRPHSPR
KPASASNNRV LDSYRYSEAN LEESADVDLD ALIGELCALE SQLNATDPGG GLSLLTVSRP
QQVYGCRRFS RVGSSDVQHP GKPQPANPCS QDQQQSQRCR SPDTDSAYCE TMSMLSESTQ
SSGNRSGESG GSSIDSTRDS MTTPSPTQLM EAVQAKIRNV KEEIQRENLT EAEMMARLKN
EKIKIALEKM KEASVKKLFV KVFTLDGKSK NILIDERWTV AYVLRQLAEK YQVLPTHRHA
IVEFYPDLYM ERIYEDHELI VENILMWTEN SPNRLLFTER SDKYDMFCCP ENYLLDHTHS
DRNSVFGLDA RQQLIEEFFT PSRVQPPELE GPLYLKSDGK KSWKKYLFVL RGSGLYYVPK
GKSKSSKDLT CLMNFDVVQV YSAVGWKKKY KAPSNYGFAL KHPQIQVKAS KYIKYLCAED
EKTCQRWIAC IRIAKNGRQL LQNYERGSTL LAEEHQAKLS PDHANSAERF NGLPHHRQEQ
LQAELSDVLG SNELPDLSRG GATAGASSVN GLGVVGRPKT VTDVRRDQLN RSSKTLTPVE
APTISAKDEM RVSVSQCCSP ALMPKACSIS DARSICGSTD STDRVDQLSL NAFESDSCTG
TIKRQPSKNC AGAKVSASDV NRQQMPLAFV SRKESLLNKQ APVMNPDKVL EQQQSMVDLT
ISCDASAAEE ENDSDEELPP APPPYAHFLQ HSASKESADE FPPPPSPVCF LADTQLLTSA
PDDYGLLCRE SEVPVVAASL VVHAPTECAP VLQTEKVAPP SAASSGNRSC KLPPPPPPKR
SETTRLSCAT PTNARCNGRP TIPAKPKPAV QTKVGVDHCS KENAVDNFHA ELQMAMQKRL
RCLEDSQRQS
//
