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Database: UniProt
Entry: A0A085NSD6_9BILA
LinkDB: A0A085NSD6_9BILA
Original site: A0A085NSD6_9BILA 
ID   A0A085NSD6_9BILA        Unreviewed;      3287 AA.
AC   A0A085NSD6;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   05-JUN-2019, entry version 33.
DE   RecName: Full=Phosphoinositide phospholipase C {ECO:0000256|RuleBase:RU361133};
DE            EC=3.1.4.11 {ECO:0000256|RuleBase:RU361133};
GN   ORFNames=M514_01694 {ECO:0000313|EMBL:KFD72382.1};
OS   Trichuris suis (pig whipworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC   Trichinellida; Trichuridae; Trichuris.
OX   NCBI_TaxID=68888 {ECO:0000313|EMBL:KFD72382.1};
RN   [1] {ECO:0000313|EMBL:KFD72382.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DCEP-RM93F {ECO:0000313|EMBL:KFD72382.1};
RX   PubMed=24929829; DOI=10.1038/ng.3012;
RA   Jex A.R., Nejsum P., Schwarz E.M., Hu L., Young N.D., Hall R.S.,
RA   Korhonen P.K., Liao S., Thamsborg S., Xia J., Xu P., Wang S.,
RA   Scheerlinck J.P., Hofmann A., Sternberg P.W., Wang J., Gasser R.B.;
RT   "Genome and transcriptome of the porcine whipworm Trichuris suis.";
RL   Nat. Genet. 46:701-706(2014).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-
CC         bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a
CC         1,2-diacyl-sn-glycerol + H(+); Xref=Rhea:RHEA:33179,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17815,
CC         ChEBI:CHEBI:58456, ChEBI:CHEBI:203600; EC=3.1.4.11;
CC         Evidence={ECO:0000256|RuleBase:RU361133};
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DR   EMBL; KL367478; KFD72382.1; -; Genomic_DNA.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:UniProtKB-EC.
DR   GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   CDD; cd00204; ANK; 1.
DR   CDD; cd14473; FERM_B-lobe; 1.
DR   Gene3D; 2.60.40.150; -; 1.
DR   Gene3D; 3.20.20.190; -; 2.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR020683; Ankyrin_rpt-contain_dom.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR000008; C2_dom.
DR   InterPro; IPR035892; C2_domain_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR019748; FERM_central.
DR   InterPro; IPR001192; PI-PLC_fam.
DR   InterPro; IPR028398; PLC-epsilon1.
DR   InterPro; IPR017946; PLC-like_Pdiesterase_TIM-brl.
DR   InterPro; IPR015359; PLC_EF-hand-like.
DR   InterPro; IPR000909; PLipase_C_PInositol-sp_X_dom.
DR   InterPro; IPR001711; PLipase_C_Pinositol-sp_Y.
DR   InterPro; IPR000159; RA_dom.
DR   InterPro; IPR023578; Ras_GEF_dom_sf.
DR   InterPro; IPR001895; RASGEF_cat_dom.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR10336; PTHR10336; 1.
DR   PANTHER; PTHR10336:SF6; PTHR10336:SF6; 1.
DR   Pfam; PF00168; C2; 1.
DR   Pfam; PF09279; EF-hand_like; 1.
DR   Pfam; PF00373; FERM_M; 1.
DR   Pfam; PF00388; PI-PLC-X; 1.
DR   Pfam; PF00387; PI-PLC-Y; 1.
DR   Pfam; PF00788; RA; 2.
DR   Pfam; PF00617; RasGEF; 1.
DR   PRINTS; PR00390; PHPHLIPASEC.
DR   SMART; SM00248; ANK; 3.
DR   SMART; SM00239; C2; 1.
DR   SMART; SM00148; PLCXc; 1.
DR   SMART; SM00149; PLCYc; 1.
DR   SMART; SM00314; RA; 2.
DR   SMART; SM00147; RasGEF; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF48366; SSF48366; 1.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   SUPFAM; SSF51695; SSF51695; 1.
DR   SUPFAM; SSF54236; SSF54236; 2.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50004; C2; 1.
DR   PROSITE; PS50008; PIPLC_Y_DOMAIN; 1.
DR   PROSITE; PS50200; RA; 2.
DR   PROSITE; PS50009; RASGEF_CAT; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Guanine-nucleotide releasing factor {ECO:0000256|PROSITE-
KW   ProRule:PRU00168}; Hydrolase {ECO:0000256|RuleBase:RU361133};
KW   Lipid degradation {ECO:0000256|RuleBase:RU361133};
KW   Lipid metabolism {ECO:0000256|RuleBase:RU361133};
KW   Transducer {ECO:0000256|SAAS:SAAS01019513}.
FT   DOMAIN      175    233       ANK_REP_REGION. {ECO:0000259|PROSITE:
FT                                PS50297}.
FT   DOMAIN     1528   1797       Ras-GEF. {ECO:0000259|PROSITE:PS50009}.
FT   DOMAIN     2671   2833       PI-PLC Y-box. {ECO:0000259|PROSITE:
FT                                PS50008}.
FT   DOMAIN     2858   2941       C2. {ECO:0000259|PROSITE:PS50004}.
FT   DOMAIN     3007   3105       Ras-associating. {ECO:0000259|PROSITE:
FT                                PS50200}.
FT   DOMAIN     3135   3253       Ras-associating. {ECO:0000259|PROSITE:
FT                                PS50200}.
FT   REGION      276    339       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A085NSD6}.
FT   REGION      497    525       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A085NSD6}.
FT   REGION      822    862       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A085NSD6}.
FT   REGION     1040   1060       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A085NSD6}.
FT   REGION     1706   1726       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A085NSD6}.
FT   REGION     1764   1783       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A085NSD6}.
FT   REGION     2116   2153       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A085NSD6}.
FT   REGION     2530   2626       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A085NSD6}.
FT   REGION     3257   3287       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A085NSD6}.
FT   COILED     2194   2214       {ECO:0000256|SAM:Coils}.
FT   COMPBIAS    286    339       Polar. {ECO:0000256|MobiDB-lite:
FT                                A0A085NSD6}.
FT   COMPBIAS    498    520       Polyampholyte. {ECO:0000256|MobiDB-lite:
FT                                A0A085NSD6}.
FT   COMPBIAS    822    836       Polar. {ECO:0000256|MobiDB-lite:
FT                                A0A085NSD6}.
FT   COMPBIAS    845    862       Polar. {ECO:0000256|MobiDB-lite:
FT                                A0A085NSD6}.
FT   COMPBIAS   1764   1782       Polyampholyte. {ECO:0000256|MobiDB-lite:
FT                                A0A085NSD6}.
FT   COMPBIAS   2542   2558       Polyampholyte. {ECO:0000256|MobiDB-lite:
FT                                A0A085NSD6}.
FT   COMPBIAS   2559   2581       Acidic. {ECO:0000256|MobiDB-lite:
FT                                A0A085NSD6}.
FT   COMPBIAS   3259   3287       Polar. {ECO:0000256|MobiDB-lite:
FT                                A0A085NSD6}.
SQ   SEQUENCE   3287 AA;  368220 MW;  54721DB475F1F44E CRC64;
     MPALSPGDGD HCSLDERKAR DTLLKRTEKA LKNGEDIFVL KLIARLKNQQ ARHDWQHQES
     FDEIGTSFID SGSQRRLTTK SLQICLDYCL RLAIVYQRKE VVELLLKSGL HPDHLINCDC
     FDDSKEGGHG RALVDASVRQ EEQAQVPLRQ SSLNGQLPPS LLAALSSPSC VDCRPLILAV
     ETKNVDIVSL LCRYNASVDL SDSQDRTALL AAVQLSPLPL AIVEILLEHG ARIGPSRCSS
     AAPVDLMPEL FRMQKTLIKD LVHKAILLWK ANGLERSPPD QDEKSQPAMR ISNRYSEPES
     VKQSPSKQSG RTGQALFYVT SGSPKTSRPS GLQSQSPSGF ACKEESDGII KSLKCLVNNP
     ECLQYVTDAL LQEEGNILLK SHHNVDNCEL DECISQLLEE ILVVALKEYE APFLQSGRKE
     AASISSNPKL HNLFKSIVRF CLELLTKGGS CSRFTAFHVL NQVIDICISK GFLVWPQVKF
     LSTELLSMQC PVGVSRPHER RSLGESTKSR IAHQPKRKND SVTVDQTSNS CKEALCDILE
     PLSALEPNIL VMLLHNALTM EKRSGDVKYG CLPSRRSRRC AHCSLILCAR ILLFLCHQEE
     IRKQLADPQN IRLLVQMLDV TLEPQFLCYM LQIVATLALD RKTRSVLRDL RADELLVQML
     LPGDEWYYTN QTMIFPKVVK HHAARILIYI GMGHMVGNRV NLFNCPNVAN LADSSTNSSE
     SPLIKELHNE VEDRYILKTC LSPQFVETTS GTILYSVEGL LMKLLNTVGD IPEDGNSKIS
     QSYLSWTIAL VDPLLLLRLL LHKFSWDVGF LQYRGRSSSG HSFGVPAGQV QKSKSFDRQL
     PKALDSETDN ANSMLRSGSM RTDNALKQTH HGRGSLTASE TCSEGVRTKS NFSKYIQNLF
     RTKRAKMNSI ASTHSNQNSD TESLLEFQKK LQNLPPRCSM DEDNVNYFSS LPLKVVGQKD
     GQSICFYPND SECSVCAENS ARQTRNDGST ENAGNACQSL AVPQIQIEIR RASVLSQFSV
     GQGLSSSAVE CLPLLTAPTN MSRRSSGTTT SPYSGTSQLS SQRSSVVSSL VFSNSSSPLP
     SSDHVPFVFN VATPNRRASS VISIMPRISV RSLAERPILS ADMSTLKIIL ECIINIFGRG
     NDGINDVLKE TRNLFGKIMA VTEDMQVKEW CAVMMQFMTI KEVMEESEVY NPDRLGDEYF
     ELQDQIASGS LPCSKDEAAL LASIQSLIEE KWPSSKRQLS RLLSYRRLRE ISQKISTLTW
     DSENANPPLL IRPLLFSMNK EKTRNSSKEQ SQKNVFNRLL CKTLSLSINA EALEHCLPAN
     YRESKQIIKL IQVWKRKLFH SNFYDSENGL KHLYVQTCKR LPAFGCKLFH VKELYRGKLL
     RKSRRILCLG AAYISLLRPS TKTLIRKQKT VSLLRWHVGS GSTDRSLTLD FGTTKWYFMV
     PSAMLRKTIG MTLWELVQIN TPKTVQKAFS SKLEEAEPPS AAFHLTGADG LPVMFHGLFV
     SESLNGFLEE SATLYSLELE RLQSVFYFPE EVAFQLSAIE YDLVYSISPM DYVTYVICDL
     NQVRLNLNPS QVRMLIKRFA EVSSWVTHLI LSQPSHEDRR NMLCFIVRAA ETCWNIGNFN
     GATEILYGLS SEKLQPFWLS LSAENKRKFM NLSEILLSQE PSIELRKATQ RALSCNSFRP
     IPFFGTFLKD LYTIFQSIPS LVPGEKAAED RDNAKVEKTS ASIDSSLPDH STSFFSEHIG
     VTSFLNSQKI ELIQTVLDNL ETFHSHSRSR HSNEKGDEGE QPNSRTLEII QPLTEMPSPT
     LMSLRRIDAD LMQRLQHGCS VIYYECETAR SAFCHLHLDT TCSYIKWQKS NFSSWLTTTV
     GKGGAQNLDS LSAVGSECKE ASGSSEVDSR KVRASISPQP VLSSSSTSAD DFSKRIKLLS
     GVPAYRSMED GLIVLTYVKS VEICNNPDFD ILAVYQRHCT DTTVPPKCFS VVYGGTLTDN
     YTVYFVAPEM TASVLTEGLA QILNELKNQY CHHDRRLFWL RKLYLDLLSA DQNFLIAANP
     STALQAFGGR AFWTDQLSAF GSPSEHSSPT FKKTKSVRYP SQRGYLPTAK LKKLSVTGEQ
     GFPSRVRLSI RNSFRLSSGS SQDSSSSKVN NVLASSKMTS EAKGQSAGES KRSTLASLVS
     PSTMHKKSIG DIQENPLNFL EFTELFKLFS IRMRKDLRDL FKEQVRRYQE QEKQQQQHLF
     LKSDSKSSTC DIHLLPSHSG ETSDKKNAAA GKDTDPFMND AFIDKLMPDQ LMRQMSTSKR
     IADKQMKIYD ALATASIAQN SAGVDTSRSM WLTAAAIKSF MRIHQMELIS DAQAVELIAR
     HEPDAVMRSK QRMSFEGFAR FLLDSSNFAY LNEDNKMNKK DMDYPLSYYF IASSHNTYLT
     GHQLKGESSV ELYRQILMTG CRCIEFDCWD GDDGQPVIYH GHTLTTKINF RQVVEIVRRS
     AFEVSSLPVI ISIENHCSLP LQAKMAQTFK SVFGERLVSQ FLFENDLSDN PRLPSPLQLK
     GKVLIKNKKL SFEPPPPLGD RSSKVDGHKS QKGSLMEWSM EEEEDEEAQY DFDDNDEDDE
     EVNREAKVAD TGVNKLSPSS KLQSNKMYKS KDDSASSDTS STKNDPAVLA THGNLIAPAQ
     YGSELTASSE ELYKASSKKT GGPVPQVAPE LSDLVIYCQA VKFKGFAISG DAELAQKRAG
     TSSVKKMGNS MQPVPASPGM DFASTENVQT HAYRTPCFQV SCYQLPSMNE TTAKKLIRKH
     PLELVAFTKD HILRTYPSAV RIDSSNFNPL MFWTFGIQMV ALNYQTQDIP MAINAAMFEQ
     NGNCGYMLKP RVMWDETHPL YGTFNPWAHD LRKISGIRLI LNIISGQFVC PGQADASPYV
     EVELMGIEAD SWKERTKTVQ RNGLNPIWLQ TFQFQVNFLD LCFLRLAVIE SGSNKCTAQR
     VIPLKALRAG YRHVRLRSPN NCPLEYSSIF IYSRMEEEEF IYVDGESTEN KVHTLPQNGE
     IPIFKQQIYV LKIYGVCPDN SSTTVQAQST TVAREVIDMA LKNCGHEADL LDDYVLMEDL
     WMPEPSTTRQ VQVSRRVLEP DELIMNAVAN WNGANGRFVL RKKGSDPSSR AWMNTIIRSS
     KEKLPKQSCK ASERSEITFL VCVHNVSEDQ DYAILRVPVN STANDIINQV LIKARRTENS
     SAFVLVEETE ESVGAMDTSG GSGKTFIVSS SGGTSSKAAH KKTRRVLSDD TNVFALQMGW
     KTPSRFLLEK RTNINEAQKV EKPKSNSLNV LRSLNLRKKQ PAPTAQS
//
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