ID A0A086B2R8_9FLAO Unreviewed; 441 AA.
AC A0A086B2R8;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Hydroxymethylglutaryl-CoA synthase {ECO:0000313|EMBL:KFF23232.1};
GN ORFNames=IQ37_14320 {ECO:0000313|EMBL:KFF23232.1};
OS Chryseobacterium piperi.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales; Weeksellaceae;
OC Chryseobacterium group; Chryseobacterium.
OX NCBI_TaxID=558152 {ECO:0000313|EMBL:KFF23232.1, ECO:0000313|Proteomes:UP000028709};
RN [1] {ECO:0000313|EMBL:KFF23232.1, ECO:0000313|Proteomes:UP000028709}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CTM {ECO:0000313|EMBL:KFF23232.1,
RC ECO:0000313|Proteomes:UP000028709};
RA Pipes S.E., Stropko S.J., Newman J.D.;
RT "Genome of Chryseobacterium piperi CTM.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. HMG-CoA synthase
CC family. {ECO:0000256|ARBA:ARBA00007061}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KFF23232.1}.
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DR EMBL; JPRJ01000030; KFF23232.1; -; Genomic_DNA.
DR RefSeq; WP_034686175.1; NZ_JPRJ01000030.1.
DR AlphaFoldDB; A0A086B2R8; -.
DR STRING; 558152.IQ37_14320; -.
DR KEGG; cpip:CJF12_19785; -.
DR eggNOG; COG3425; Bacteria.
DR OrthoDB; 9769523at2; -.
DR Proteomes; UP000028709; Unassembled WGS sequence.
DR GO; GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IEA:InterPro.
DR GO; GO:0006084; P:acetyl-CoA metabolic process; IEA:InterPro.
DR GO; GO:0010142; P:farnesyl diphosphate biosynthetic process, mevalonate pathway; IEA:InterPro.
DR CDD; cd00827; init_cond_enzymes; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR InterPro; IPR013746; HMG_CoA_synt_C_dom.
DR InterPro; IPR013528; HMG_CoA_synth_N.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43323; 3-HYDROXY-3-METHYLGLUTARYL COENZYME A SYNTHASE; 1.
DR PANTHER; PTHR43323:SF2; HYDROXYMETHYLGLUTARYL-COA SYNTHASE; 1.
DR Pfam; PF08540; HMG_CoA_synt_C; 1.
DR Pfam; PF01154; HMG_CoA_synt_N; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000028709}.
FT DOMAIN 3..176
FT /note="Hydroxymethylglutaryl-coenzyme A synthase N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF01154"
FT DOMAIN 308..406
FT /note="Hydroxymethylglutaryl-coenzyme A synthase C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF08540"
SQ SEQUENCE 441 AA; 50103 MW; 7BFC3901B73314D3 CRC64;
MTFGIEAVGY YIPSLYLEIK DLAEKRGIEP AKLEKGLGLH RMGFPDVHED AATFAAEALL
KLIKDYQINP EDIARIYLGT ESALDAAKPT ASYAMQMVEK VLEEEFGERC FKNCDVVDMT
FACVGAVDAL HNSLDFVRVN PDKKAIVIAS DYAKYELSSP GEYTQGGGAV ALLVSSEPNL
LEIENFWGVA TESVFDFFKP RRYYQKEELT TAPETYPDKI EIFTDEPVFD GQYSNQCYQD
RIREAYSHYK EITGKDKPYK DWKYLIFHLP YAFHGKRVFT EIFSLENGLS YRTPEEQKVV
AKSEDYLQFI NEKIEKSQRA SSEIGNMYTA SIFMALLSAL QTSFNDGEEL TGEKIGFLGY
GSGSKSKVFA GAVSKNWKNV VSKWNLFENL NERTAIDFES YEKLHRKQLK ESVNPDYSGF
GLESVETDNP VLNGARYYNY K
//
