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Database: UniProt
Entry: A0A086D521_9GAMM
LinkDB: A0A086D521_9GAMM
Original site: A0A086D521_9GAMM 
ID   A0A086D521_9GAMM        Unreviewed;       354 AA.
AC   A0A086D521;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   11-DEC-2019, entry version 22.
DE   RecName: Full=Phospho-2-dehydro-3-deoxyheptonate aldolase {ECO:0000256|PIRNR:PIRNR001361};
DE            EC=2.5.1.54 {ECO:0000256|PIRNR:PIRNR001361};
GN   ORFNames=GY26_08015 {ECO:0000313|EMBL:KFF49535.1};
OS   Gammaproteobacteria bacterium MFB021.
OC   Bacteria; Proteobacteria; Gammaproteobacteria.
OX   NCBI_TaxID=1492922 {ECO:0000313|EMBL:KFF49535.1, ECO:0000313|Proteomes:UP000028732};
RN   [1] {ECO:0000313|EMBL:KFF49535.1, ECO:0000313|Proteomes:UP000028732}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MFB021 {ECO:0000313|EMBL:KFF49535.1,
RC   ECO:0000313|Proteomes:UP000028732};
RA   Joseph T.C., Baby A., Varghese A.M., Reghunathan D., Murugadas V.,
RA   Lalitha K.V.;
RT   "Draft Genome sequence of a halophilic and highly halotolerant unknown
RT   Gammaproteobacteria strain MFB021.";
RL   Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Stereospecific condensation of phosphoenolpyruvate (PEP) and
CC       D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-
CC       heptulosonate-7-phosphate (DAHP). {ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-
CC         phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate;
CC         Xref=Rhea:RHEA:14717, ChEBI:CHEBI:15377, ChEBI:CHEBI:16897,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58394, ChEBI:CHEBI:58702; EC=2.5.1.54;
CC         Evidence={ECO:0000256|PIRNR:PIRNR001361};
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate biosynthesis;
CC       chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step
CC       1/7. {ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- SIMILARITY: Belongs to the class-I DAHP synthase family.
CC       {ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KFF49535.1}.
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DR   EMBL; JNVT01000061; KFF49535.1; -; Genomic_DNA.
DR   RefSeq; WP_035472540.1; NZ_JNVT01000061.1.
DR   STRING; 1492922.GY26_08015; -.
DR   EnsemblBacteria; KFF49535; KFF49535; GY26_08015.
DR   OrthoDB; 853329at2; -.
DR   UniPathway; UPA00053; UER00084.
DR   Proteomes; UP000028732; Unassembled WGS sequence.
DR   GO; GO:0003849; F:3-deoxy-7-phosphoheptulonate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009423; P:chorismate biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR006218; DAHP1/KDSA.
DR   InterPro; IPR006219; DHAP_synth_1.
DR   PANTHER; PTHR21225; PTHR21225; 1.
DR   Pfam; PF00793; DAHP_synth_1; 1.
DR   PIRSF; PIRSF001361; DAHP_synthase; 1.
DR   TIGRFAMs; TIGR00034; aroFGH; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|PIRNR:PIRNR001361};
KW   Aromatic amino acid biosynthesis {ECO:0000256|PIRNR:PIRNR001361};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028732};
KW   Transferase {ECO:0000256|PIRNR:PIRNR001361, ECO:0000256|SAAS:SAAS00080156,
KW   ECO:0000313|EMBL:KFF49535.1}.
FT   DOMAIN          51..343
FT                   /note="DAHP_synth_1"
FT                   /evidence="ECO:0000259|Pfam:PF00793"
SQ   SEQUENCE   354 AA;  38103 MW;  84E1BC46E5F38E33 CRC64;
     MNAVTSALKP AAESAPRRRE LTLPSAAELR AAIPLERVLA ARVERQRDAI RDVLAGRDER
     LLVVVGPCSI HDPDAALEYA ERLAALQASV ADRLLLVMRV YVEKPRTTVG WKGLAYDPHL
     DGSDDMAAGL ASARRLMRDV AALGLPVATE LLQPMAAAYF DDLLSWVAIG ARTTESQIHR
     ELASGLDACV GFKNGTQGNV DVAVAAMQSA AHPHRHFGVT AEGTPAMIET PGNPFTHLVL
     RGGQDGPNHD AASIAASRRA LETAGLTPRL MVDCSHANSR KDHRRQTEVL HSVVDQRLAG
     ERALMGVMLE SHLFEGKQPL NPAALRYGVS ITDACLGWET TAQQLIRAAE RLRG
//
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