ID A0A086GVT3_STRSC Unreviewed; 531 AA.
AC A0A086GVT3;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Sodium:proton exchanger {ECO:0000313|EMBL:KFF99500.1};
GN ORFNames=IQ62_17720 {ECO:0000313|EMBL:KFF99500.1};
OS Streptomyces scabiei.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1930 {ECO:0000313|EMBL:KFF99500.1, ECO:0000313|Proteomes:UP000028722};
RN [1] {ECO:0000313|EMBL:KFF99500.1, ECO:0000313|Proteomes:UP000028722}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCPPB 4086 {ECO:0000313|EMBL:KFF99500.1,
RC ECO:0000313|Proteomes:UP000028722};
RA Harrison J., Sapp M., Thwaites R., Studholme D.J.;
RT "Genome sequencing of plant-pathogenic Streptomyces species.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Na(+)/H(+) antiporter that extrudes sodium in exchange for
CC external protons. {ECO:0000256|RuleBase:RU366002}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU366002};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU366002}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 1 (CPA1)
CC transporter (TC 2.A.36) family. {ECO:0000256|RuleBase:RU366002}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU366002}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KFF99500.1}.
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DR EMBL; JPPX01000117; KFF99500.1; -; Genomic_DNA.
DR RefSeq; WP_037695154.1; NZ_KL997422.1.
DR AlphaFoldDB; A0A086GVT3; -.
DR OrthoDB; 57886at2; -.
DR Proteomes; UP000028722; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015385; F:sodium:proton antiporter activity; IEA:InterPro.
DR Gene3D; 6.10.140.1330; -; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR018422; Cation/H_exchanger_CPA1.
DR InterPro; IPR004705; Cation/H_exchanger_CPA1_bac.
DR NCBIfam; TIGR00831; a_cpa1; 1.
DR PANTHER; PTHR10110; SODIUM/HYDROGEN EXCHANGER; 1.
DR PANTHER; PTHR10110:SF86; SODIUM_HYDROGEN EXCHANGER 7; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
PE 3: Inferred from homology;
KW Antiport {ECO:0000256|RuleBase:RU366002};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|RuleBase:RU366002};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU366002};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU366002};
KW Signal {ECO:0000256|SAM:SignalP};
KW Sodium {ECO:0000256|ARBA:ARBA00023053, ECO:0000256|RuleBase:RU366002};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU366002};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU366002};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU366002};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU366002}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..531
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5001807198"
FT TRANSMEM 82..104
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 110..132
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 181..201
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 221..245
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 266..287
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 299..323
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 344..367
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 379..402
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT DOMAIN 8..402
FT /note="Cation/H+ exchanger"
FT /evidence="ECO:0000259|Pfam:PF00999"
SQ SEQUENCE 531 AA; 57612 MW; E67D5AB87CAAA4DA CRC64;
MHFLPLLLLV AGSATVAGAA RRTPVPAPLL LVAAGLAVSY LPGVPHYELD PEIVLPLILP
PLLYTAAGDS SYLDLRAQLR PVALLSVGYV LFATLVVGWA AYLIVPGLPL TAALVLGAVV
APPDAVAATA VARRVGLPSR VTTILQGESL VNDATAITAY RVALAATIGE GASWTGGIVE
FLVAAVGGVA VGLLLMMPMH WLRTHLKEAL LKNTLSLLIP FVAYGLAEWV HASGVLAVVV
VGLYLGYRNW QVDFATRLQE EAVWKMVAFL LESAVFALIG LQLPVVLEGL GEYEGVRASW
YAVAVFLVVV ASRFVWVYPA TFLPRMLSKR IREREDNPTW KAPFVIAWAG MRGVVSLAIA
FSIPLTVNGG DDFPGRNLIL FLTFTTVIGT LVIQGLTLPP LIRVLKLPGR DQRAETLAEA
NAQAQASRAA EARLDELLAN EHNELPPPLV DRLRSVLERR RNAVWERLGA VNPVTGESVD
DTYSRLSREM IGSERHVFVK LRDGRYIDDE MLRTLLRRLD LEEAAVYREA S
//
