ID   A0A086H3H5_STRSC        Unreviewed;       594 AA.
AC   A0A086H3H5;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   SubName: Full=Short-chain dehydrogenase {ECO:0000313|EMBL:KFG02193.1};
GN   ORFNames=IQ62_03035 {ECO:0000313|EMBL:KFG02193.1};
OS   Streptomyces scabiei.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1930 {ECO:0000313|EMBL:KFG02193.1, ECO:0000313|Proteomes:UP000028722};
RN   [1] {ECO:0000313|EMBL:KFG02193.1, ECO:0000313|Proteomes:UP000028722}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCPPB 4086 {ECO:0000313|EMBL:KFG02193.1,
RC   ECO:0000313|Proteomes:UP000028722};
RA   Harrison J., Sapp M., Thwaites R., Studholme D.J.;
RT   "Genome sequencing of plant-pathogenic Streptomyces species.";
RL   Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC       family. {ECO:0000256|ARBA:ARBA00006484}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KFG02193.1}.
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DR   EMBL; JPPX01000040; KFG02193.1; -; Genomic_DNA.
DR   RefSeq; WP_037689557.1; NZ_KL997396.1.
DR   AlphaFoldDB; A0A086H3H5; -.
DR   OrthoDB; 4220752at2; -.
DR   Proteomes; UP000028722; Unassembled WGS sequence.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   CDD; cd05233; SDR_c; 1.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR000073; AB_hydrolase_1.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR   InterPro; IPR002347; SDR_fam.
DR   PANTHER; PTHR43391:SF12; OXIDOREDUCTASE EPHD-RELATED; 1.
DR   PANTHER; PTHR43391; RETINOL DEHYDROGENASE-RELATED; 1.
DR   Pfam; PF00561; Abhydrolase_1; 1.
DR   Pfam; PF00106; adh_short; 1.
DR   PRINTS; PR00081; GDHRDH.
DR   PRINTS; PR00080; SDRFAMILY.
DR   SMART; SM00822; PKS_KR; 1.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS00061; ADH_SHORT; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
FT   DOMAIN          39..288
FT                   /note="AB hydrolase-1"
FT                   /evidence="ECO:0000259|Pfam:PF00561"
SQ   SEQUENCE   594 AA;  64702 MW;  B05D4AC28974C33C CRC64;
     MTEGGDVTDA VTLEGVRERR VRSGGVELCV AELGDPEQPT VVLVHGYPDT KEVWSEVAVR
     LAERFHVVLY DVRGHGGSTA PEPLRGGFTL EKLTDDFLAV VDAVSPGHPV HLVGHDWGSV
     QGWEFATVER TEGRIASFTS MSGPSLDHLG HWIKRRVKRP TPRRIGQLLG QGAKSWYVYV
     LHTPVLPELA WRGPLGKQWP RLVRRAEKLP RGDYPSPSLP TDAAHGAWLY RDNMRARLAR
     PRDDAYAHAP VQLITPLADQ FLSEQLYEDL ESWAPQLLRR TLPAKHWVPR TRPDQLAAWI
     TEFVTATEGG RPAPVATGKY TDRFGGQLVL VTGAAGGIGR ATAFAFAEAG ARVVAVDLDT
     EGAARTAELS RLIGAPEAWA EAVDVSDEQA MEKLSEKVAA EYGVVDVLVN NAGIGLSGSF
     LDTTPEDWRK VLDVNLWGVI HGCRLFGRQM AERGQGGHIV NTASAAAYLP SRSLPAYSTS
     KAAVLMLSEC LRAELAGQGI GVSAICPGIV NTNITSTARF AGVDAEEEKR RQRKTTRLYG
     LRNYPPEKVA DAVLRAVVRN QAVVPVTPEA HGGRFMSRFA PRALRALARL EPPL
//