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Database: UniProt
Entry: A0A086TCQ7_ACRC1
LinkDB: A0A086TCQ7_ACRC1
Original site: A0A086TCQ7_ACRC1 
ID   A0A086TCQ7_ACRC1        Unreviewed;       605 AA.
AC   A0A086TCQ7;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   23-MAY-2018, entry version 15.
DE   RecName: Full=Malic enzyme {ECO:0000256|RuleBase:RU003426};
GN   ORFNames=ACRE_020450 {ECO:0000313|EMBL:KFH47139.1};
OS   Acremonium chrysogenum (strain ATCC 11550 / CBS 779.69 / DSM 880 / JCM
OS   23072 / IMI 49137).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
OC   Sordariomycetes; Hypocreomycetidae; Hypocreales;
OC   Hypocreales incertae sedis; Acremonium.
OX   NCBI_TaxID=857340 {ECO:0000313|EMBL:KFH47139.1, ECO:0000313|Proteomes:UP000029964};
RN   [1] {ECO:0000313|Proteomes:UP000029964}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 11550 / CBS 779.69 / DSM 880 / JCM 23072 / IMI 49137
RC   {ECO:0000313|Proteomes:UP000029964};
RX   PubMed=25291769; DOI=10.1128/genomeA.00948-14;
RA   Terfehr D., Dahlmann T.A., Specht T., Zadra I., Kuernsteiner H.,
RA   Kueck U.;
RT   "Genome sequence and annotation of Acremonium chrysogenum, producer of
RT   the beta-lactam antibiotic cephalosporin C.";
RL   Genome Announc. 2:E0094814-E0094814(2014).
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|PIRSR:PIRSR000106-3};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|PIRSR:PIRSR000106-3};
CC       Note=Divalent metal cations. Prefers magnesium or manganese.
CC       {ECO:0000256|PIRSR:PIRSR000106-3};
CC   -!- SIMILARITY: Belongs to the malic enzymes family.
CC       {ECO:0000256|RuleBase:RU003426}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KFH47139.1}.
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DR   EMBL; JPKY01000012; KFH47139.1; -; Genomic_DNA.
DR   EnsemblFungi; KFH47139; KFH47139; ACRE_020450.
DR   Proteomes; UP000029964; Unassembled WGS sequence.
DR   GO; GO:0005739; C:mitochondrion; IEA:EnsemblFungi.
DR   GO; GO:0004471; F:malate dehydrogenase (decarboxylating) (NAD+) activity; IEA:EnsemblFungi.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0006520; P:cellular amino acid metabolic process; IEA:EnsemblFungi.
DR   GO; GO:0006108; P:malate metabolic process; IEA:EnsemblFungi.
DR   GO; GO:0006090; P:pyruvate metabolic process; IEA:EnsemblFungi.
DR   Gene3D; 3.40.50.10380; -; 1.
DR   InterPro; IPR015884; Malic_enzyme_CS.
DR   InterPro; IPR012301; Malic_N_dom.
DR   InterPro; IPR037062; Malic_N_dom_sf.
DR   InterPro; IPR012302; Malic_NAD-bd.
DR   InterPro; IPR001891; Malic_OxRdtase.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00390; malic; 1.
DR   Pfam; PF03949; Malic_M; 1.
DR   PIRSF; PIRSF000106; ME; 1.
DR   PRINTS; PR00072; MALOXRDTASE.
DR   SMART; SM01274; malic; 1.
DR   SMART; SM00919; Malic_M; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS00331; MALIC_ENZYMES; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000029964};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR000106-3,
KW   ECO:0000256|RuleBase:RU003426};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU003426};
KW   Reference proteome {ECO:0000313|Proteomes:UP000029964}.
FT   DOMAIN       91    273       malic. {ECO:0000259|SMART:SM01274}.
FT   DOMAIN      283    544       Malic_M. {ECO:0000259|SMART:SM00919}.
FT   ACT_SITE    115    115       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR000106-1}.
FT   ACT_SITE    187    187       Proton acceptor. {ECO:0000256|PIRSR:
FT                                PIRSR000106-1}.
FT   METAL       258    258       Divalent metal cation.
FT                                {ECO:0000256|PIRSR:PIRSR000106-3}.
FT   METAL       259    259       Divalent metal cation.
FT                                {ECO:0000256|PIRSR:PIRSR000106-3}.
FT   METAL       282    282       Divalent metal cation.
FT                                {ECO:0000256|PIRSR:PIRSR000106-3}.
SQ   SEQUENCE   605 AA;  66563 MW;  6E8532643F72872C CRC64;
     MPSNMKSSKF SHLPLSTSGP VDCALTGTAL LNTPYLNKGS AFPPEERRQF KLTGLLPQGA
     QTLEQQTKRA YQQYSSRPDN LSKNTFLTSL KDQNEVLYYK KLLQDHLSEM LSVVYTPTEG
     DAIQNYSRLF RRPEGCYLNI NDQDRIFSDM AQWGQPDDID YIVVSDGEEI LGIGDQGVGG
     ILISVAKLVL TTLCAGIHPS RSLPVVLDCG TDNRDLLDDD LYLGLREKRV RGRKYDEFVD
     EFVRAARKLY PKAYIHFEDF GLSNARRILE QYRPKMPCFN DDVQGTGCVT LAAIMAGLQI
     SGQKLSDVRM VIFGAGSAGV GIADQVRDAI ATEGNISRQE AAKQTWLIDK LGLLTTESDA
     AEAQKAYLKD ASDWSGKETG LQSVVESVHP HVLIGTSTVP GAFTEPIIRA MGKHTSRPII
     LPLSNPTRLH EAKPSDLLKW TDGKALVATG SPFEPISGPW GKDGEEVTIQ IAECNNSVVF
     PGIGLGCVLS RASRLTDRML VAAVQGLASL SPTKNDPRAP LLPDVVEVRN VSVRIARCVI
     RAAVEEGVAT EEGIPDEDEE LDEWIREQMW DPVYRPLKLV EMEGATRSAR GELRKSGSVI
     RNFVL
//
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