ID A0A086ZJ49_9BIFI Unreviewed; 367 AA.
AC A0A086ZJ49;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 24-JAN-2024, entry version 41.
DE RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000256|HAMAP-Rule:MF_00081};
GN Name=hrcA {ECO:0000256|HAMAP-Rule:MF_00081};
GN ORFNames=BBOH_0018 {ECO:0000313|EMBL:KFI46549.1};
OS Bifidobacterium bohemicum DSM 22767.
OC Bacteria; Actinomycetota; Actinomycetes; Bifidobacteriales;
OC Bifidobacteriaceae; Bifidobacterium.
OX NCBI_TaxID=1437606 {ECO:0000313|EMBL:KFI46549.1, ECO:0000313|Proteomes:UP000029096};
RN [1] {ECO:0000313|EMBL:KFI46549.1, ECO:0000313|Proteomes:UP000029096}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 22767 {ECO:0000313|EMBL:KFI46549.1,
RC ECO:0000313|Proteomes:UP000029096};
RA Ventura M., Milani C., Lugli G.A.;
RT "Genomics of Bifidobacteria.";
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC dnaJ and groELS operons). Prevents heat-shock induction of these
CC operons. {ECO:0000256|HAMAP-Rule:MF_00081}.
CC -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000256|HAMAP-
CC Rule:MF_00081}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KFI46549.1}.
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DR EMBL; JGYP01000001; KFI46549.1; -; Genomic_DNA.
DR RefSeq; WP_033520133.1; NZ_JGYP01000001.1.
DR AlphaFoldDB; A0A086ZJ49; -.
DR STRING; 1437606.BBOH_0018; -.
DR eggNOG; COG1420; Bacteria.
DR OrthoDB; 9783139at2; -.
DR Proteomes; UP000029096; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.450.40; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR HAMAP; MF_00081; HrcA; 1.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR002571; HrcA.
DR InterPro; IPR021153; HrcA_C.
DR InterPro; IPR013196; HTH_11.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR NCBIfam; TIGR00331; hrcA; 1.
DR PANTHER; PTHR34824; HEAT-INDUCIBLE TRANSCRIPTION REPRESSOR HRCA; 1.
DR PANTHER; PTHR34824:SF1; HEAT-INDUCIBLE TRANSCRIPTION REPRESSOR HRCA; 1.
DR Pfam; PF01628; HrcA; 1.
DR Pfam; PF08279; HTH_11; 1.
DR PIRSF; PIRSF005485; HrcA; 2.
DR SUPFAM; SSF55781; GAF domain-like; 2.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000029096};
KW Repressor {ECO:0000256|ARBA:ARBA00022491, ECO:0000256|HAMAP-Rule:MF_00081};
KW Stress response {ECO:0000256|ARBA:ARBA00023016, ECO:0000256|HAMAP-
KW Rule:MF_00081};
KW Transcription {ECO:0000256|ARBA:ARBA00023163, ECO:0000256|HAMAP-
KW Rule:MF_00081};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015, ECO:0000256|HAMAP-
KW Rule:MF_00081}.
FT DOMAIN 18..57
FT /note="Helix-turn-helix type 11"
FT /evidence="ECO:0000259|Pfam:PF08279"
FT DOMAIN 104..345
FT /note="Heat-inducible transcription repressor HrcA C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF01628"
SQ SEQUENCE 367 AA; 39732 MW; FB91ED7A4EB43518 CRC64;
MKQSRRMLVL RAVIEDYIRT QEPVGSSTLA REYGLGVSSA TIRNDMAALE DEGYLIQPHT
SAGRIPTERG YRYFVDELAS VVRLSAAQRR AIANFLSDSV SLQDALERSV RLLSHITGQV
AIVSGPSLAK SRVRRIEIVP LSTTTMLAVI ITDAGSVAQH TLSLDVTLPS DRIMDLSDEI
NRVCINSSLS AAAGCIRRLA AVQDLREMSN FAIKLARTVE AMANDERSGQ LYIAGTSQLA
HQQPTEDLAP LFDALEEQAV IMRLMNNLSQ QNGEVGVAIG SETKTPGLMS SAVVSSGYGH
SMVDQISADR SADADRPDND NYRQDAPVAF VGSIGPTHMD YAATMSAVRA VARYLTELIA
QDDTGWS
//
