ID   A0A087CXI4_9BIFI        Unreviewed;      1424 AA.
AC   A0A087CXI4;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   27-MAR-2024, entry version 45.
DE   RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE            EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN   ORFNames=BREU_0764 {ECO:0000313|EMBL:KFI87984.1};
OS   Bifidobacterium reuteri DSM 23975.
OC   Bacteria; Actinomycetota; Actinomycetes; Bifidobacteriales;
OC   Bifidobacteriaceae; Bifidobacterium.
OX   NCBI_TaxID=1437610 {ECO:0000313|EMBL:KFI87984.1, ECO:0000313|Proteomes:UP000028984};
RN   [1] {ECO:0000313|EMBL:KFI87984.1, ECO:0000313|Proteomes:UP000028984}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 23975 {ECO:0000313|EMBL:KFI87984.1,
RC   ECO:0000313|Proteomes:UP000028984};
RA   Ventura M., Milani C., Lugli G.A.;
RT   "Genomics of Bifidobacteria.";
RL   Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00034618};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KFI87984.1}.
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DR   EMBL; JGZK01000002; KFI87984.1; -; Genomic_DNA.
DR   RefSeq; WP_044090109.1; NZ_JGZK01000002.1.
DR   STRING; 1437610.BREU_0764; -.
DR   eggNOG; COG0210; Bacteria.
DR   eggNOG; COG2887; Bacteria.
DR   OrthoDB; 5240387at2; -.
DR   Proteomes; UP000028984; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR   GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR   InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR   InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR038726; PDDEXK_AddAB-type.
DR   PANTHER; PTHR11070:SF59; DNA HELICASE; 1.
DR   PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR   Pfam; PF12705; PDDEXK_1; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:KFI87984.1};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028984}.
FT   DOMAIN          345..651
FT                   /note="UvrD-like helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51217"
FT   REGION          569..614
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          976..1013
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        577..596
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        987..1007
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1424 AA;  154631 MW;  FFC7F0F1F8CBD573 CRC64;
     MNENLNPARL IDELERDGAS RLVIGVPDAG KTEYALQVML EGLRRYGASR VVMTVSSRVV
     ADSLGNRVIR ELGASDQVRP VTTIGAVAFR VIASSRAAQG LPAPRLLNGA EQDALLRRVL
     AVHVGHAVAG DDCGTCALLR DYFAQAQWAS LVVDDHGAVS GGSTSADVFT QGISDTFVSQ
     LRDMLARLDE LGVGPHEEPA LVDAVAADGR LTVQWRLAFA LRREYIEAQR QAYPGQYRVD
     ASYLLVDGAR EIRGIRASHV RQDAMDIPRL VVVDDVQDIT LAGLRFLEEL HQSGVSIVLI
     GNPDEAVQTF RGSYPEYVIR RAVTGPLQAV VLPLQRDVAP DRHEGYADVV ASRVSLSIPS
     EEEEELPLSR RPGKLLAALR VASQTGLEHD GTVQTGLYRS AREELDDVVW RIKRAHLDRR
     VRWNDMAVIA HDNATVRSFG ERLRRDGVPV RYSSVTRPLK DESFIQGLFA FIELAYLRME
     GMSGRDGRNG WRGMALTRMA AYVRARVNTI MNSPLVTTGT RPGQGGPARL APVESAMDAL
     ESLAPVADQD AMLSELVHGW ESLMSMMPEA SRKGQDESKT LSAGISDSTA GRSDSMTAES
     DAVEDAGQTA ESGQPLIQVD DALVEDGAVS QDELGFGSDA LFVMLALDDE SAPVASVLAA
     IDAVLGGNPQ SRAFSRVWRM VATICAQLRA LPYDQRENPG NVLSIAWNAV EVASAWQSTA
     LLNTADGRVA NDRLDAAMRL FQFATDSSAS ATIRGFMTQV RTMQVQADSL AHVGPVEDAV
     TLATPAGASG RHWPYVWIPA LQEGVWPNLA GRNTMFGGEE LVELVLRGAL AAADGTGHDP
     RFVTVLSGEK KSFLVALTRA SRQVTVSAVW NDKSSPSDFL FGYLPEMYSR DKEQSRFTEV
     GNRQDGVESD AWFGLDGDPR GLVAIARVTL SSAAEDSDEL NDAAAALGIL AAHGIAAAHP
     DDWPFVLQCS TPDAAPSIYG NTDDPTSASD HDQDDHANQH ADGRLRSPDD GAPVVTLSPS
     AVDGLWACPV CWMLEHQFAG PQPGSVNAGF GTLIHAVAQQ GSEERLDHLH DDDEVLRGLG
     LNASSTSEQR VQAVAERLVE IYRGKRPDPD AIADVQERYR AIRKDDSASD MLKHIASYFV
     QGAEDAYLEK NSSKFSIGTL VQADCELPFS ARFGFDDILA AYNAVPGVHA VDRDTLIAMM
     GELVGGWPEG VDENMTVRLS GRIDRMETRR LADGREIKRL IDYKTGAVPV GRQIFNDLQL
     VCYQLGLVFP EGGPRGAAAL RKAPRIEQSE LFHVAKNMAP AQSFAPEGMF QPPLFTEGSL
     NAEPFTVRYH YASPSAWYDM PVLCAEQRPE HVGEAAWEQC MSLNGTQVIW SLTMIARVFY
     AAAASRSIRL DAHPQSEHVR FCRMGNVCPA CARQVDTVFE TRQA
//