ID   A0A087EIA4_9BIFI        Unreviewed;       886 AA.
AC   A0A087EIA4;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   27-MAR-2024, entry version 44.
DE   RecName: Full=DNA topoisomerase (ATP-hydrolyzing) {ECO:0000256|ARBA:ARBA00012895};
DE            EC=5.6.2.2 {ECO:0000256|ARBA:ARBA00012895};
GN   ORFNames=BITS_0758 {ECO:0000313|EMBL:KFJ07505.1};
OS   Bifidobacterium tsurumiense.
OC   Bacteria; Actinomycetota; Actinomycetes; Bifidobacteriales;
OC   Bifidobacteriaceae; Bifidobacterium.
OX   NCBI_TaxID=356829 {ECO:0000313|EMBL:KFJ07505.1, ECO:0000313|Proteomes:UP000029080};
RN   [1] {ECO:0000313|EMBL:KFJ07505.1, ECO:0000313|Proteomes:UP000029080}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JCM 13495 {ECO:0000313|EMBL:KFJ07505.1,
RC   ECO:0000313|Proteomes:UP000029080};
RA   Ventura M., Milani C., Lugli G.A.;
RT   "Genomics of Bifidobacteria.";
RL   Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP-dependent breakage, passage and rejoining of double-
CC         stranded DNA.; EC=5.6.2.2; Evidence={ECO:0000256|ARBA:ARBA00000185};
CC   -!- SIMILARITY: Belongs to the type II topoisomerase GyrA/ParC subunit
CC       family. {ECO:0000256|ARBA:ARBA00008263}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KFJ07505.1}.
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DR   EMBL; JGZU01000004; KFJ07505.1; -; Genomic_DNA.
DR   RefSeq; WP_026642580.1; NZ_JGZU01000004.1.
DR   AlphaFoldDB; A0A087EIA4; -.
DR   STRING; 356829.BITS_0758; -.
DR   eggNOG; COG0188; Bacteria.
DR   OrthoDB; 9806486at2; -.
DR   Proteomes; UP000029080; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0034335; F:DNA negative supercoiling activity; IEA:UniProt.
DR   GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR   CDD; cd00187; TOP4c; 1.
DR   Gene3D; 3.30.1360.40; -; 1.
DR   Gene3D; 2.120.10.90; DNA gyrase/topoisomerase IV, subunit A, C-terminal; 1.
DR   Gene3D; 3.90.199.10; Topoisomerase II, domain 5; 1.
DR   Gene3D; 1.10.268.10; Topoisomerase, domain 3; 1.
DR   InterPro; IPR006691; GyrA/parC_rep.
DR   InterPro; IPR035516; Gyrase/topoIV_suA_C.
DR   InterPro; IPR013760; Topo_IIA-like_dom_sf.
DR   InterPro; IPR013758; Topo_IIA_A/C_ab.
DR   InterPro; IPR013757; Topo_IIA_A_a_sf.
DR   InterPro; IPR002205; Topo_IIA_dom_A.
DR   PANTHER; PTHR43493:SF5; DNA GYRASE SUBUNIT A, CHLOROPLASTIC_MITOCHONDRIAL; 1.
DR   PANTHER; PTHR43493; DNA GYRASE/TOPOISOMERASE SUBUNIT A; 1.
DR   Pfam; PF03989; DNA_gyraseA_C; 2.
DR   Pfam; PF00521; DNA_topoisoIV; 1.
DR   SMART; SM00434; TOP4c; 1.
DR   SUPFAM; SSF101904; GyrA/ParC C-terminal domain-like; 1.
DR   SUPFAM; SSF56719; Type II DNA topoisomerase; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:KFJ07505.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000029080};
KW   Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT   DOMAIN          23..476
FT                   /note="DNA topoisomerase type IIA"
FT                   /evidence="ECO:0000259|SMART:SM00434"
FT   COILED          448..475
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   886 AA;  95413 MW;  643527BD92FBAE50 CRC64;
     MAHRKTSQPA FDPRTVHENI IETPLNEEMS KSFLEYAYSV IYARALPDAR DGLKPVQRRI
     VYQMGQMNLT PDRAYMKSAR VVGEVMGKLH PHGDSAIYDA MVRLAQPFAM RLPLVDGHGN
     FGSLDDGPAA SRYTEARLAP AALGMNASID EDTVDFTPNY DNKLQEPTVL PSAIPNLLVN
     GASGIAVGMA TNMATHNLGE VVAAAKYLMA HPDASLEALM RFVPGPDWPG GGVIIGRDGI
     REAYEHGRGA LTTRSTTHIE NVTARKKAIV VTELPFMVGP ERVLERISEG VKNRKLEGIS
     GAIDLSDRHN GTRLVIEIKT GFDPHAVLAQ LFKHTPLQDN FTMNNVALVN GRPHTMGLKE
     MLDVWIDHRR RVIRRRSEFR RRKAEERLHL VEGLLLALID IDEVIQVIRT SEDAEAAKTR
     LIAVFDLDEV QAQYILDLRL RRLTRMSRIE LESERDDLRK RIEELERILG SAEELDRVVT
     DEMDQAVAQW GSPRRTVLLD SDESGALVPV VSEAGSAALP AQATAAIRSA QTVSSAAADV
     AAAAAARKAG EDDAAAAALQ LDDEPCAVLL SASGLIARST PTAVDAWQSR SAMDHRGPDE
     QIVSIVSTTT LSTYGLITSA GRLVVAHAAE LPVVPASAIL SVASGVRADD LLALTESTDP
     VPGEHVISAV ALAEDHTNPL ALGTTMGVVK RWNRESPTTM DSWSVIDLKD GDSVIFAADA
     NDEDRLVFIS SDSSLLTYEA SNVRPQGRTA GGMAGIRLAE DCTVVAFNVI SAGKVSWTYD
     EDDDGLFSAS GAVVLTVAGD KDALPGTENG AAKITPLEMY PTKGRGTGGV RSQRFLKGQN
     ILIAAHIGEY PLSASTEGGS TVELPKPDMR RDASGVELAS PIAYIG
//