ID A0A087FXY1_ARAAL Unreviewed; 1182 AA.
AC A0A087FXY1;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase {ECO:0000256|ARBA:ARBA00011982};
DE EC=3.2.2.6 {ECO:0000256|ARBA:ARBA00011982};
GN ORFNames=AALP_AAs46524U000200 {ECO:0000313|EMBL:KFK22483.1};
OS Arabis alpina (Alpine rock-cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Arabideae; Arabis.
OX NCBI_TaxID=50452 {ECO:0000313|EMBL:KFK22483.1, ECO:0000313|Proteomes:UP000029120};
RN [1] {ECO:0000313|Proteomes:UP000029120}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Pajares {ECO:0000313|Proteomes:UP000029120};
RX PubMed=27246759; DOI=10.1038/nplants.2014.23;
RA Willing E.M., Rawat V., Mandakova T., Maumus F., James G.V.,
RA Nordstroem K.J., Becker C., Warthmann N., Chica C., Szarzynska B.,
RA Zytnicki M., Albani M.C., Kiefer C., Bergonzi S., Castaings L.,
RA Mateos J.L., Berns M.C., Bujdoso N., Piofczyk T., de Lorenzo L.,
RA Barrero-Sicilia C., Mateos I., Piednoel M., Hagmann J., Chen-Min-Tao R.,
RA Iglesias-Fernandez R., Schuster S.C., Alonso-Blanco C., Roudier F.,
RA Carbonero P., Paz-Ares J., Davis S.J., Pecinka A., Quesneville H.,
RA Colot V., Lysak M.A., Weigel D., Coupland G., Schneeberger K.;
RT "Genome expansion of Arabis alpina linked with retrotransposition and
RT reduced symmetric DNA methylation.";
RL Nat. Plants 1:14023-14023(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide;
CC Xref=Rhea:RHEA:16301, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:17154, ChEBI:CHEBI:57540, ChEBI:CHEBI:57967; EC=3.2.2.6;
CC Evidence={ECO:0000256|ARBA:ARBA00000404};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16302;
CC Evidence={ECO:0000256|ARBA:ARBA00000404};
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DR EMBL; KL988722; KFK22483.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A087FXY1; -.
DR EnsemblPlants; KFK22483; KFK22483; AALP_AAs46524U000200.
DR Gramene; KFK22483; KFK22483; AALP_AAs46524U000200.
DR eggNOG; ENOG502QQ7T; Eukaryota.
DR OrthoDB; 679287at2759; -.
DR Proteomes; UP000029120; Unassembled WGS sequence.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0006952; P:defense response; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR045344; C-JID.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR011713; Leu-rich_rpt_3.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR11017:SF600; ADP-RIBOSYL CYCLASE_CYCLIC ADP-RIBOSE HYDROLASE-RELATED; 1.
DR PANTHER; PTHR11017; LEUCINE-RICH REPEAT-CONTAINING PROTEIN; 1.
DR Pfam; PF20160; C-JID; 1.
DR Pfam; PF07725; LRR_3; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS50104; TIR; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Reference proteome {ECO:0000313|Proteomes:UP000029120};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 13..177
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT REGION 1060..1088
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1060..1076
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1182 AA; 133924 MW; 43C20B6545458584 CRC64;
MASSSSSSST PTWKYDVFPS FSGEDVRKSF LSHLLHAFKR IAIISFIDNG IERSHLIADE
LLLAIRQSRI SIVIFSNKYV SSTWCLNELA EIHDCHEESD QMVIPIFYEV DPSHVRKQTG
EFGKAFDMTC KGKTEDHIER WKKALAKVAG LAGYDSQNWK DEAEAIELIS TDVSNKLLLA
PLDDFRDFVG MQAHVKTIMD SKLCLDSGEV RMIGIWGPSG IGKSTIATAL FNRLSSTQFD
HRAFLTYERD KKIADVRVKL TWAEEFLSKI LCQTDIKINS LGVVEQRLKH RKVLVVLDNV
DDLELLKTLV GKTEWFGFGS RIIVTTQDKE ILKAHEIDLI YEVEFPSKDL ALQMFCQSAF
GQTSPPDGFM ELAVEIVQLA GKLPLGLNVL GSSLKGKKDK EKCVDKEKWV DMMPRLRNGL
NKNIDTTLRI CYDGLSEEDD QDIFVYIACL FNGQSVHYIK NLLHDSLSVI TSLDTLADKS
LIRKIGPHHV VQMHILLQKL GRKIACEESI TNPKPNPNPG EHRFLLNAKE ISDVFEDNTG
TNKVLGIHCN ISEIDGPLSM NENSFKGMSN LRFLKIYKER SGPETGEVRL DLPEGLVFLP
KKLRSLQWDE YPAECIPSTF KAEHLVELTM QRSKLKKLWE RTQRLRSLRK MNLSYSRDLE
EIPDLSDAKN LIKLVLNYCK SLVTLPSSIR GLNKLTWIWM HGCTKLEVLP TDVNLESLYL
LDLRGCSKLR SFPPLSRNIS ILYLDGTSME EENCLGIENL TRLHQLSWKN CPLRYLPPNF
HPERLYQLLL EGSKLEKLWE GVKSVRNLGV MSLSGCKNLI ELPDLSTAIN LADLDLSQCE
SLKEIPDLSK ALPLFKMKLS GCKSLKEIPN LSNARNLKEL DMSRCTSLKL LPTNFKLGAS
TSLNLTGCSQ LTSLDEDAQK FILDSAFKYA ILPGKEVPTY FTHRIRGSSL TVPLPQSALS
QRKFEFRACI VPGLVTGSLS PKMIIIHCKF RSVTGMFKVD SVTDFCEMDH MVVFYFAFCP
QDEVDLSFQL DVMFEFEVRL DTNEPIPACK IKECGVRVLD DPSQDANDRS SETEYTDQPE
ESDEETERCK KRIRFRDKDA LMMQMTGEPS QEQSERGKKA LHVLEDVSLD PVITVREDAE
IPTEDTTSSS QLVNYLRVQT VEDFLFTIAA DDETADDEDN IS
//
