ID A0A087GW63_ARAAL Unreviewed; 3020 AA.
AC A0A087GW63;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN OrderedLocusNames=AALP_Aa5g103600 {ECO:0000313|EMBL:KFK34115.1};
OS Arabis alpina (Alpine rock-cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Arabideae; Arabis.
OX NCBI_TaxID=50452 {ECO:0000313|EMBL:KFK34115.1, ECO:0000313|Proteomes:UP000029120};
RN [1] {ECO:0000313|Proteomes:UP000029120}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Pajares {ECO:0000313|Proteomes:UP000029120};
RX PubMed=27246759; DOI=10.1038/nplants.2014.23;
RA Willing E.M., Rawat V., Mandakova T., Maumus F., James G.V.,
RA Nordstroem K.J., Becker C., Warthmann N., Chica C., Szarzynska B.,
RA Zytnicki M., Albani M.C., Kiefer C., Bergonzi S., Castaings L.,
RA Mateos J.L., Berns M.C., Bujdoso N., Piofczyk T., de Lorenzo L.,
RA Barrero-Sicilia C., Mateos I., Piednoel M., Hagmann J., Chen-Min-Tao R.,
RA Iglesias-Fernandez R., Schuster S.C., Alonso-Blanco C., Roudier F.,
RA Carbonero P., Paz-Ares J., Davis S.J., Pecinka A., Quesneville H.,
RA Colot V., Lysak M.A., Weigel D., Coupland G., Schneeberger K.;
RT "Genome expansion of Arabis alpina linked with retrotransposition and
RT reduced symmetric DNA methylation.";
RL Nat. Plants 1:14023-14023(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; CM002873; KFK34115.1; -; Genomic_DNA.
DR EnsemblPlants; KFK34115; KFK34115; AALP_AA5G103600.
DR Gramene; KFK34115; KFK34115; AALP_AA5G103600.
DR eggNOG; KOG0892; Eukaryota.
DR OMA; FSHIWEV; -.
DR OrthoDB; 8448at2759; -.
DR Proteomes; UP000029120; Chromosome 5.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05171; PIKKc_ATM; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR038980; ATM_plant.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR044107; PIKKc_ATM.
DR PANTHER; PTHR37079; SERINE/THREONINE-PROTEIN KINASE ATM; 1.
DR PANTHER; PTHR37079:SF4; SERINE_THREONINE-PROTEIN KINASE ATM; 1.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000029120};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1891..2557
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 2663..2975
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 2988..3020
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
SQ SEQUENCE 3020 AA; 341831 MW; 9DF1DFD7E4ECE161 CRC64;
MVTSRDVHEV VSKLSSDKAK AREEGLKLLN TWLEGERSIT FCRFLSQNTA KLKFDEIPNA
ETWPFLVKIL LQCVSMEVSG SKRRMPKPTF AKTLRVVIQR AEETKFPGVL FPLLSMAKII
FTHVHDILSN TPSFQSEYGT ILRHLLEIRE YRFQMRKRTY SSLVLLYIER AEAGFCEKNS
GQHSQKEEAF RYILTLQSLL ENPPGDFPDD LREEIVNGLI HIFSSVRDEG KLSRKLIECV
NSFLLKDGPN IGSLSLDIHN AVQQFVFRCW LTTHDKNLKE ILASYGRLQL NLTRGSSESS
SLVEQLLDVV TRELDHGSSS SSASWGDSTK DDKFGTLSSY QNSLVELASH VLYRAVGNTT
RPSLSEKRAR RQHIASRLVE ALTEGKWLWC AAFGCLVRTY GTRINNDLLI YWFDAICTNF
QRLLEDASMR RSYDGLLWTL RSLQGLASGL LLPDTTMDIS KSSVSSNELD RGWQLIWSSL
IHGLATFSSM SVIVDAVLML LGSVISSNHI NVGILPQEVW DHQLFRHIPS EPALYFIACY
FSRMGCQGNL QDDLHLRRNL LRAVCAPLSW KGRLTLNERM VQLLPAAAFS LCSGFTTSLP
LPKEHLPTPS EWDAYEVVND VVKIDDVEQE RKFGLFEYSV EVLTRVCSNS SKISSCRVPD
GVQLPLVLRD PLLHDMEIYF LSITPEDSEK GPLSDIFIGC SLLCHFMHGS YITRKGKGSS
SFFLKACQYL LESLDYAVEA VLKSLNDFQR LGPLGFGSDF NEKSSIVVSM RSLTSSPVFS
NRRDQNLLAT SYDAIFQSLE NLLRSFAKVY GEYTEQSWNT QSDTVSSKSL ALDSPEVGRI
VDMDLDLAED TKEIDLITAG GKSVPGMPVS TGNWKLGMIS LIACFSPVLQ FPTWDVLYSI
MEKECDPKVL ENILFHLCQL SCSTSMPKVN DLVIFLDGML NTQVKLKRNC LNIVTALHVL
LKNLSSSGMD SSGLGANCEL SLKEGESCQV FVQLGAMVNK VSEFGLLGWF GRVRLINCIC
DFVLLNPQIG QTMIDRLLLM LNDSDYRVRF VLARQIGLLF QTWDGHEALF QDICSSFGIV
LVTSSREKVV TARDVLAAGP QPRPKMETVI ITLMHLAYHS ENIELQAVFM MCAISAIDPC
QRELIIAALD NLSAQLHYPS RFKYLEELLG PILFFWIACG VSLAALVETR QLFILNAEPK
YFIHFCSHWL LPALLLYEDH TNLDWVAKMA GQPVAVLVKE NFVPIFSICM GLHCSKTSEC
DKGAMVLQNS ILYVGEISEN DRDKLIKRNM VSIVSFVLSR ASSSLDPPVP AFSRDTISRA
VQTVVDGFLE TADYPKNEAV IDKINVFRPD RVFMFITEIH YRMSAACHHR HTRHHLAALE
ELTTILGHRA SVPSTLNYIF NLVGQFICSP SLQDQCCSIA SCLLDSFKSN PAKEIVSVLG
DQLQFLVSTL VTCCIDAEAD SKVSGSKSSQ LVNLLHKLIV SSESSLDEDI RDLEPFPDME
NFQVIRESHI RICEAYSPRN HLLKCARRSC YLPPRFLSWS LQALHNKLIA SEASQDETNV
ETADTFWHSD DEIVNAVWTL VRVSASDEAD SMRLLVSDFL SRVGIGDPHT VVFHLPGEMG
SLHDLQFASH NSGSKVRSFT ENGISDETLI VLLKILKKYL LDDSVKIIDV TSQTLRGILS
TGRGQQAQLS IDACERSLIE VHGRGVNLDI VEKILVDSQK QFKAENFSLE MSEVWATDNK
NFDGWICQLV YCMIALCEDV PIRLCQNIAI LKAEIAELLF PSVIVSLAGR IGKNINLHEL
ITSQVKEHIF IDSNKLTKSK QIMLNTLNEL RMCYVLERST FSGQTKREKS TKHSSSNAAK
IRDVETSSNG MAAPITAKWD KVYWLSIDYL VVARSAVVCG AYLTASMYVE YWCEEKFGSL
SLGDPDFSYH DKLPDHVEIL VSAITRINEP DSLYGVIHSN KLSAQIITFE HEGNWTRALE
YYDLQARSQK MIMPGRLSED PVVEHFQQTT SAQHSVFGEG EVQRQPFKGL IRSLQQTGCM
HVLDLYCRGL TSREGCFQYD PEFIELQYEA AWRAGKWDFS LLYPQTHCQP LQHVKNNSYH
ENLHCCLRAL QEGDCDGFYG KLKDAKKELV LSISRASEES TDFIYSTVVK LQILYHLGLV
WDLRWMSSAH QSVHGYPVKQ MACTDPMIPT MEQLSWLNKD WSSIITQTQL HMNLLEPFMA
FRRVLLQILG CEECTMQHSL QSASLLRKGS RFSQAAAFLH EFKFLCARSD GQQPVPDWLG
KLEEAKLLHA QGRHEVAISL ASYILQNYQL KEEASDIYRV IGKWLAETRS SNSRTILEKY
LKPAVSLAEE QGSKICKRLV ERQSQTWFHL AHYADALFKS YEERLSSSEW QAAMRLRKHK
TKELEVLIKR FKSSKKGEQS DYSLKIQELQ KQLTMDKEEA EKLQVDRDNF LKLALEGYQR
CLEIGDKYDV RVVFRQVSMW FNLASHKNVI DNMLSTIKEV QSYKFVPLVY QIASRLGSSR
DESGSNSFQS ALVSLVRKMA IDHPYHTIFQ LLALANGDRI KDNQRSRNSF VVDMDKKLAA
EHLLQDVSHY HGPMIRQMKQ LVDIYIKLAE LETRREDTNK RVALPREIRS VKQLELVPVV
TATIPVDRSC QYNEGSFPSF RGLSDSVIVM NGINAPKVVE CFGSDGRKYK QLAKSGNDDL
RQDAVMEQFF GLVNTFLHNN RDTWKRRLAV RTYKVIPFTP SAGVLEWVDG TIPLGDYLIG
SSRSEGAHGR YGIGNWKYPK CREHMLNAKD KQKGFMDVCT NFRPVMHYFF LEKFLQPADW
FVKRLAYTRS VAASSMVGYI VGLGDRHAMN ILIDQATAEV VHIDLGVAFE QGLMLKTPER
VPFRLTRDII DGMGITGVEG VFRKCCEETL SVMRTNKEAL LTIVEVFIHD PLYKWALSPL
KALQRQKETE DYDGMNLEGL QEEFEGNKDA ARALMRVKQK LDGYEGGEMR SIHGQAQQLI
QDAIDADRLA HMFPGWGAWM
//