ID   A0A087GZN9_ARAAL        Unreviewed;       450 AA.
AC   A0A087GZN9;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   27-MAR-2024, entry version 38.
DE   RecName: Full=Cytochrome b5 heme-binding domain-containing protein {ECO:0000259|PROSITE:PS50255};
GN   OrderedLocusNames=AALP_Aa5g272100 {ECO:0000313|EMBL:KFK35341.1};
OS   Arabis alpina (Alpine rock-cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Arabideae; Arabis.
OX   NCBI_TaxID=50452 {ECO:0000313|EMBL:KFK35341.1, ECO:0000313|Proteomes:UP000029120};
RN   [1] {ECO:0000313|Proteomes:UP000029120}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Pajares {ECO:0000313|Proteomes:UP000029120};
RX   PubMed=27246759; DOI=10.1038/nplants.2014.23;
RA   Willing E.M., Rawat V., Mandakova T., Maumus F., James G.V.,
RA   Nordstroem K.J., Becker C., Warthmann N., Chica C., Szarzynska B.,
RA   Zytnicki M., Albani M.C., Kiefer C., Bergonzi S., Castaings L.,
RA   Mateos J.L., Berns M.C., Bujdoso N., Piofczyk T., de Lorenzo L.,
RA   Barrero-Sicilia C., Mateos I., Piednoel M., Hagmann J., Chen-Min-Tao R.,
RA   Iglesias-Fernandez R., Schuster S.C., Alonso-Blanco C., Roudier F.,
RA   Carbonero P., Paz-Ares J., Davis S.J., Pecinka A., Quesneville H.,
RA   Colot V., Lysak M.A., Weigel D., Coupland G., Schneeberger K.;
RT   "Genome expansion of Arabis alpina linked with retrotransposition and
RT   reduced symmetric DNA methylation.";
RL   Nat. Plants 1:14023-14023(2015).
CC   -!- SIMILARITY: Belongs to the fatty acid desaturase type 1 family.
CC       {ECO:0000256|ARBA:ARBA00009295}.
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DR   EMBL; CM002873; KFK35341.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A087GZN9; -.
DR   EnsemblPlants; KFK35341; KFK35341; AALP_AA5G272100.
DR   Gramene; KFK35341; KFK35341; AALP_AA5G272100.
DR   eggNOG; KOG4232; Eukaryota.
DR   OMA; ENQMEYK; -.
DR   OrthoDB; 294339at2759; -.
DR   Proteomes; UP000029120; Chromosome 5.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:EnsemblPlants.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0052631; F:sphingolipid delta-8 desaturase activity; IEA:EnsemblPlants.
DR   GO; GO:0070417; P:cellular response to cold; IEA:EnsemblPlants.
DR   GO; GO:0030148; P:sphingolipid biosynthetic process; IEA:EnsemblPlants.
DR   CDD; cd03506; Delta6-FADS-like; 1.
DR   Gene3D; 3.10.120.10; Cytochrome b5-like heme/steroid binding domain; 1.
DR   InterPro; IPR001199; Cyt_B5-like_heme/steroid-bd.
DR   InterPro; IPR036400; Cyt_B5-like_heme/steroid_sf.
DR   InterPro; IPR005804; FA_desaturase_dom.
DR   InterPro; IPR012171; Fatty_acid_desaturase.
DR   PANTHER; PTHR19353:SF69; CYTOCHROME B5 HEME-BINDING DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR19353; FATTY ACID DESATURASE 2; 1.
DR   Pfam; PF00173; Cyt-b5; 1.
DR   Pfam; PF00487; FA_desaturase; 1.
DR   PIRSF; PIRSF015921; FA_sphinglp_des; 1.
DR   SMART; SM01117; Cyt-b5; 1.
DR   SUPFAM; SSF55856; Cytochrome b5-like heme/steroid binding domain; 1.
DR   PROSITE; PS50255; CYTOCHROME_B5_2; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000029120};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        114..134
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        140..161
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        256..276
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        288..308
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          8..92
FT                   /note="Cytochrome b5 heme-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS50255"
SQ   SEQUENCE   450 AA;  51651 MW;  B38DB4BBE3AECF01 CRC64;
     MAETTVEKKY ITNSDLSKHN KPGDLWIAIQ GKVYNVSDWI KSHPGGDTVI LNLVGQDVTD
     AFIAFHPGTA WHNLEPLFTG YHLRDFEVSD VSRDYRKMAA EFRKLGLFEK KGHVTLYTLA
     FIASMFAGVL YGVLACTSII VHQIAAALLG LLWIQSAYIG HDSGHYVIMA NESYNRIAQL
     ISGNCLTGIS IAWWKWTHNA HHLACNSLDY DPDLQHIPVF AVSTKFFNSM TSRFYDRKLT
     FDPVARFLIS YQHWTYYPVM CFGRINLFIQ TFLLLFSTRE VPDRALNFAG ILVFWTWFPL
     LVSCLPTWPE RFFFVFTSFT VTALQHIQFT LNHFAADVYM GPPTGNDWFE KQAAGTLDIT
     CVSYMDWFYG GLQFQLEHHL FPRLPRCHLR KVSPVVKELC KKHNLPYRSL SWWDANVLTI
     ETLKKAAYHA RDAANPVVKN LVWEALNTHG
//