ID A0A087H9D3_ARAAL Unreviewed; 803 AA.
AC A0A087H9D3;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=Protein ROOT HAIR DEFECTIVE 3 homolog {ECO:0000256|HAMAP-Rule:MF_03109};
DE EC=3.6.5.- {ECO:0000256|HAMAP-Rule:MF_03109};
DE AltName: Full=Protein SEY1 homolog {ECO:0000256|HAMAP-Rule:MF_03109};
GN OrderedLocusNames=AALP_Aa3g153600 {ECO:0000313|EMBL:KFK38735.1};
OS Arabis alpina (Alpine rock-cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Arabideae; Arabis.
OX NCBI_TaxID=50452 {ECO:0000313|EMBL:KFK38735.1, ECO:0000313|Proteomes:UP000029120};
RN [1] {ECO:0000313|Proteomes:UP000029120}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Pajares {ECO:0000313|Proteomes:UP000029120};
RX PubMed=27246759; DOI=10.1038/nplants.2014.23;
RA Willing E.M., Rawat V., Mandakova T., Maumus F., James G.V.,
RA Nordstroem K.J., Becker C., Warthmann N., Chica C., Szarzynska B.,
RA Zytnicki M., Albani M.C., Kiefer C., Bergonzi S., Castaings L.,
RA Mateos J.L., Berns M.C., Bujdoso N., Piofczyk T., de Lorenzo L.,
RA Barrero-Sicilia C., Mateos I., Piednoel M., Hagmann J., Chen-Min-Tao R.,
RA Iglesias-Fernandez R., Schuster S.C., Alonso-Blanco C., Roudier F.,
RA Carbonero P., Paz-Ares J., Davis S.J., Pecinka A., Quesneville H.,
RA Colot V., Lysak M.A., Weigel D., Coupland G., Schneeberger K.;
RT "Genome expansion of Arabis alpina linked with retrotransposition and
RT reduced symmetric DNA methylation.";
RL Nat. Plants 1:14023-14023(2015).
CC -!- FUNCTION: Probable GTP-binding protein that may be involved in cell
CC development. {ECO:0000256|HAMAP-Rule:MF_03109}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|HAMAP-Rule:MF_03109}; Multi-pass membrane protein
CC {ECO:0000256|HAMAP-Rule:MF_03109}.
CC -!- SIMILARITY: Belongs to the TRAFAC class dynamin-like GTPase
CC superfamily. GB1/RHD3 GTPase family. RHD3 subfamily.
CC {ECO:0000256|HAMAP-Rule:MF_03109}.
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DR EMBL; CM002871; KFK38735.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A087H9D3; -.
DR EnsemblPlants; KFK38735; KFK38735; AALP_AA3G153600.
DR Gramene; KFK38735; KFK38735; AALP_AA3G153600.
DR eggNOG; KOG2203; Eukaryota.
DR OMA; PWWIYLL; -.
DR OrthoDB; 1606at2759; -.
DR Proteomes; UP000029120; Chromosome 3.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003924; F:GTPase activity; IEA:UniProtKB-UniRule.
DR CDD; cd01851; GBP; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_03109; Sey1; 1.
DR InterPro; IPR030386; G_GB1_RHD3_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR008803; RHD3/Sey1.
DR InterPro; IPR046758; Sey1/RHD3-like_3HB.
DR PANTHER; PTHR45923; PROTEIN SEY1; 1.
DR PANTHER; PTHR45923:SF2; PROTEIN SEY1; 1.
DR Pfam; PF05879; RHD3_GTPase; 1.
DR Pfam; PF20428; Sey1_3HB; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51715; G_GB1_RHD3; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|HAMAP-Rule:MF_03109};
KW GTP-binding {ECO:0000256|HAMAP-Rule:MF_03109};
KW Hydrolase {ECO:0000256|HAMAP-Rule:MF_03109};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|HAMAP-Rule:MF_03109};
KW Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_03109};
KW Reference proteome {ECO:0000313|Proteomes:UP000029120};
KW Transmembrane {ECO:0000256|HAMAP-Rule:MF_03109};
KW Transmembrane helix {ECO:0000256|HAMAP-Rule:MF_03109}.
FT TOPO_DOM 1..677
FT /note="Cytoplasmic"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_03109"
FT TOPO_DOM 699..701
FT /note="Lumenal"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_03109"
FT TOPO_DOM 723..803
FT /note="Cytoplasmic"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_03109"
FT DOMAIN 34..249
FT /note="GB1/RHD3-type G"
FT /evidence="ECO:0000259|PROSITE:PS51715"
FT REGION 757..803
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 44..51
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_03109"
SQ SEQUENCE 803 AA; 89027 MW; 3A735DFD66BF60E0 CRC64;
MDAACSTQLI DGDGTFNVSG VDNFIKEVKL EECGLSYAVV SIMGPQSSGK STLLNHLFGT
NFREMDAFRG RSQTTKGIWI ARCAGIEPCT VVMDLEGTDG RERGEDDTAF EKQSALFALA
VSDIVLINMW CHDIGREQAA NKPLLKTVFQ VMMRLFSPRK TTLMFVIRDK TRTPLENLEP
VLREDIQKIW DSVPKPQAHK ETPLSDFFNV EVVALSSYEE KEELFKEQVY NLRQRFFQSV
APGGLAGDRR GVVPANAFAF SAEQMWQVIK ENKDLDLPAH KVMVATVRCE EIANEKFSSF
IANENWRELE EAVQSGPVSG FGKKLSSILQ SSLSEYDTEA TYFEEGVRSS KRQQLQEKLL
QLVQPTFQDV LGHLRSGALE TFKDTFEKAL NAGEGFSSSA DSCAQACMSK FDKGCEGAVI
EQANWDTSKT REKLQRDIEA HISAVRTAKL SELTTLYESK LNVALSGPVE ALLDGANDET
WPAIRKLLRR EGELAVYGLS DALSGFDMDK ETRNNMLTNL ENYARGIVET KAKEEAGRAL
MRMKDRFATI FSHDSDSMPR VWTGKEDIRA ITKMARSASL KLMSVMAVLR LDDELDNIEK
TLTVALFNST NNNATSKSIG TIDSLASSTW EQVAPEKTLI TPVQCKSLWR QFKNETEYTV
TQAISAQEAN RRNNNWLPPP WAILALVVLG FNEFMTLLRN PLWLGVLFVG YLVCKALWVQ
LNISGEFRNG ALPGLLSLST KFLPTVMNLL RKLAEEGQAP STNSNQTTNS SAQSDVTTNG
ESSSSSSSSG SSPAKTVPID TSA
//
