ID   A0A087HHW0_ARAAL        Unreviewed;       530 AA.
AC   A0A087HHW0;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   27-MAR-2024, entry version 32.
DE   RecName: Full=TIR domain-containing protein {ECO:0000259|PROSITE:PS50104};
GN   OrderedLocusNames=AALP_Aa2g163700 {ECO:0000313|EMBL:KFK41712.1};
OS   Arabis alpina (Alpine rock-cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Arabideae; Arabis.
OX   NCBI_TaxID=50452 {ECO:0000313|EMBL:KFK41712.1, ECO:0000313|Proteomes:UP000029120};
RN   [1] {ECO:0000313|Proteomes:UP000029120}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Pajares {ECO:0000313|Proteomes:UP000029120};
RX   PubMed=27246759; DOI=10.1038/nplants.2014.23;
RA   Willing E.M., Rawat V., Mandakova T., Maumus F., James G.V.,
RA   Nordstroem K.J., Becker C., Warthmann N., Chica C., Szarzynska B.,
RA   Zytnicki M., Albani M.C., Kiefer C., Bergonzi S., Castaings L.,
RA   Mateos J.L., Berns M.C., Bujdoso N., Piofczyk T., de Lorenzo L.,
RA   Barrero-Sicilia C., Mateos I., Piednoel M., Hagmann J., Chen-Min-Tao R.,
RA   Iglesias-Fernandez R., Schuster S.C., Alonso-Blanco C., Roudier F.,
RA   Carbonero P., Paz-Ares J., Davis S.J., Pecinka A., Quesneville H.,
RA   Colot V., Lysak M.A., Weigel D., Coupland G., Schneeberger K.;
RT   "Genome expansion of Arabis alpina linked with retrotransposition and
RT   reduced symmetric DNA methylation.";
RL   Nat. Plants 1:14023-14023(2015).
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DR   EMBL; CM002870; KFK41712.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A087HHW0; -.
DR   EnsemblPlants; KFK41712; KFK41712; AALP_AA2G163700.
DR   Gramene; KFK41712; KFK41712; AALP_AA2G163700.
DR   eggNOG; ENOG502R41B; Eukaryota.
DR   OMA; GRRISEW; -.
DR   OrthoDB; 664965at2759; -.
DR   Proteomes; UP000029120; Chromosome 2.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR   GO; GO:0006952; P:defense response; IEA:InterPro.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR   InterPro; IPR042197; Apaf_helical.
DR   InterPro; IPR044974; Disease_R_plants.
DR   InterPro; IPR002182; NB-ARC.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000157; TIR_dom.
DR   InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR11017:SF511; ADP-RIBOSYL CYCLASE_CYCLIC ADP-RIBOSE HYDROLASE; 1.
DR   PANTHER; PTHR11017; LEUCINE-RICH REPEAT-CONTAINING PROTEIN; 1.
DR   Pfam; PF00931; NB-ARC; 1.
DR   Pfam; PF01582; TIR; 1.
DR   PRINTS; PR00364; DISEASERSIST.
DR   SMART; SM00255; TIR; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS50104; TIR; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000029120};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        497..516
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          8..141
FT                   /note="TIR"
FT                   /evidence="ECO:0000259|PROSITE:PS50104"
SQ   SEQUENCE   530 AA;  60329 MW;  32526165F09F2C8E CRC64;
     MELPRVIRQY DVFLSFRGED TRKGIVSHLH RAFRSRGIDK IFKDDNTLEI GDSISEEIKE
     AIHNSKFAVL VISKNYASST WCLDELQMIM ELHKKKQLIA VPIFYNVDPS DVRHQKGTFD
     LKSKDEATMV ADIVAQISKQ LSSMEPLDFS DIVGMKVRME QLNTLLSVES EDEVRMIGIW
     GMGGIGKTTI AKCLYEEYSR RFARYCFIEN VRISAKNGLP YLQKKLLSNI RGKKQDTLWC
     VEKGCSCIKS KIKDKIFLVL DDVDNMDQLH ALAKKTGWFG PGSRIIITTR DFGLLYSFGV
     RLLYHVSLLD NNDAIQVFNQ VAFEGGQPPS DIYQRFSIRA SRLAQGLPLA LEAFGTYLRR
     ITWIEGWEKA LRILETVPHQ SIMDILKTSF DGLDEQEQSA FLHVACLFNG DSVHRVNALI
     DDGDIRTKAL EAKSLIDISP DGCITMHVLI EQAAREIVRQ ESGSMPWRQR ILWKTDPIIF
     VLQKNTVSIS TLLDSTFFLI LISMVLAILC IVFMSTDSDS LIRVLQRLKV
//