ID A0A087HK85_ARAAL Unreviewed; 640 AA.
AC A0A087HK85;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE RecName: Full=D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding domain-containing protein {ECO:0000259|Pfam:PF02826};
GN OrderedLocusNames=AALP_Aa1g007400 {ECO:0000313|EMBL:KFK42537.1};
OS Arabis alpina (Alpine rock-cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Arabideae; Arabis.
OX NCBI_TaxID=50452 {ECO:0000313|EMBL:KFK42537.1, ECO:0000313|Proteomes:UP000029120};
RN [1] {ECO:0000313|Proteomes:UP000029120}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Pajares {ECO:0000313|Proteomes:UP000029120};
RX PubMed=27246759; DOI=10.1038/nplants.2014.23;
RA Willing E.M., Rawat V., Mandakova T., Maumus F., James G.V.,
RA Nordstroem K.J., Becker C., Warthmann N., Chica C., Szarzynska B.,
RA Zytnicki M., Albani M.C., Kiefer C., Bergonzi S., Castaings L.,
RA Mateos J.L., Berns M.C., Bujdoso N., Piofczyk T., de Lorenzo L.,
RA Barrero-Sicilia C., Mateos I., Piednoel M., Hagmann J., Chen-Min-Tao R.,
RA Iglesias-Fernandez R., Schuster S.C., Alonso-Blanco C., Roudier F.,
RA Carbonero P., Paz-Ares J., Davis S.J., Pecinka A., Quesneville H.,
RA Colot V., Lysak M.A., Weigel D., Coupland G., Schneeberger K.;
RT "Genome expansion of Arabis alpina linked with retrotransposition and
RT reduced symmetric DNA methylation.";
RL Nat. Plants 1:14023-14023(2015).
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DR EMBL; CM002869; KFK42537.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A087HK85; -.
DR EnsemblPlants; KFK42537; KFK42537; AALP_AA1G007400.
DR Gramene; KFK42537; KFK42537; AALP_AA1G007400.
DR eggNOG; KOG0067; Eukaryota.
DR OMA; NCIEDCS; -.
DR OrthoDB; 1220425at2759; -.
DR Proteomes; UP000029120; Chromosome 1.
DR GO; GO:0010494; C:cytoplasmic stress granule; IEA:EnsemblPlants.
DR GO; GO:0005829; C:cytosol; IEA:EnsemblPlants.
DR GO; GO:0005874; C:microtubule; IEA:EnsemblPlants.
DR GO; GO:0005802; C:trans-Golgi network; IEA:EnsemblPlants.
DR GO; GO:0019900; F:kinase binding; IEA:EnsemblPlants.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:EnsemblPlants.
DR GO; GO:0043621; F:protein self-association; IEA:EnsemblPlants.
DR GO; GO:0003714; F:transcription corepressor activity; IEA:InterPro.
DR GO; GO:0048826; P:cotyledon morphogenesis; IEA:EnsemblPlants.
DR GO; GO:0048444; P:floral organ morphogenesis; IEA:EnsemblPlants.
DR GO; GO:0048530; P:fruit morphogenesis; IEA:EnsemblPlants.
DR GO; GO:0031129; P:inductive cell-cell signaling; IEA:EnsemblPlants.
DR GO; GO:0000226; P:microtubule cytoskeleton organization; IEA:EnsemblPlants.
DR GO; GO:0042814; P:monopolar cell growth; IEA:EnsemblPlants.
DR GO; GO:0007097; P:nuclear migration; IEA:EnsemblPlants.
DR GO; GO:0008360; P:regulation of cell shape; IEA:EnsemblPlants.
DR GO; GO:0045604; P:regulation of epidermal cell differentiation; IEA:EnsemblPlants.
DR GO; GO:0010482; P:regulation of epidermal cell division; IEA:EnsemblPlants.
DR GO; GO:2000039; P:regulation of trichome morphogenesis; IEA:EnsemblPlants.
DR GO; GO:0009651; P:response to salt stress; IEA:EnsemblPlants.
DR GO; GO:0034063; P:stress granule assembly; IEA:EnsemblPlants.
DR GO; GO:0010091; P:trichome branching; IEA:EnsemblPlants.
DR CDD; cd05299; CtBP_dh; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR045015; AN-like.
DR InterPro; IPR043322; CtBP.
DR InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43254:SF3; C-TERMINAL BINDING PROTEIN AN; 1.
DR PANTHER; PTHR43254; C-TERMINAL BINDING PROTEIN AN-RELATED; 1.
DR Pfam; PF02826; 2-Hacid_dh_C; 1.
DR SUPFAM; SSF52283; Formate/glycerate dehydrogenase catalytic domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000029120}.
FT DOMAIN 124..306
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase NAD-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02826"
FT REGION 342..493
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 369..386
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 395..417
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 446..461
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 640 AA; 70701 MW; 30CA06ACEBE9064F CRC64;
MSKIRSSTTM PHRDQPSPAS PLIVTLNCIE DCALEQDSLA GVAGVEYIPL SRIADGKIES
ATAVLLHSLA YLPRAAQRRL RPHQLILCLG SADRAVDSTL ASDLGLRLVH VDTSRAEEIA
DTVMALILGL LRRTHLLSRH ALSASGWLGS LQPLCRGMRR CRGMVLGIVG RSVSARYLAS
RSLAFKMSVL YFDVPEGDEE RIRSSRFPRA ARRMDTLNDL LAASDVISLH CALTNETVQI
LNAECLQHIK PGAFLVNTGS CQLLDDCAVK QLLIDGTIAG CALDGAEGPQ WMEAWVKEMP
NVLILPRSAD YSEEVWMEIR EKAISILHSF FLDGVIPSNT VSDDEVEESE ASEEEELSPI
KHEKLALVES TSRQQGESTL TSTEIVRREA IDSKESLSPG QQQQVSVLPQ NTATKPEVRR
SRSGKKAKKR HSQQKYMQKA EGSSGLHEES TSRRDDTAMS DTEEVLSSSS RCASPEDSRS
RKTPLEVMQD SSQNQLVMSS KKFIGKSSEL LKDGYVVALY AKDLSGLHVS RQRTKNGGWF
LDTLSNVSKR DPAAQYIIAY RNKDTVGLRS FAAGGKLLQI NRRMEFVFAS HSFDVWESWS
LEGSLDECRL VNCRNSSAVL EVRVEILAMV GDDGITRWID
//
