ID A0A087HMD2_ARAAL Unreviewed; 412 AA.
AC A0A087HMD2;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 24-JAN-2024, entry version 38.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:KFK43284.1};
GN OrderedLocusNames=AALP_Aa1g104100 {ECO:0000313|EMBL:KFK43284.1};
OS Arabis alpina (Alpine rock-cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Arabideae; Arabis.
OX NCBI_TaxID=50452 {ECO:0000313|EMBL:KFK43284.1, ECO:0000313|Proteomes:UP000029120};
RN [1] {ECO:0000313|Proteomes:UP000029120}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Pajares {ECO:0000313|Proteomes:UP000029120};
RX PubMed=27246759; DOI=10.1038/nplants.2014.23;
RA Willing E.M., Rawat V., Mandakova T., Maumus F., James G.V.,
RA Nordstroem K.J., Becker C., Warthmann N., Chica C., Szarzynska B.,
RA Zytnicki M., Albani M.C., Kiefer C., Bergonzi S., Castaings L.,
RA Mateos J.L., Berns M.C., Bujdoso N., Piofczyk T., de Lorenzo L.,
RA Barrero-Sicilia C., Mateos I., Piednoel M., Hagmann J., Chen-Min-Tao R.,
RA Iglesias-Fernandez R., Schuster S.C., Alonso-Blanco C., Roudier F.,
RA Carbonero P., Paz-Ares J., Davis S.J., Pecinka A., Quesneville H.,
RA Colot V., Lysak M.A., Weigel D., Coupland G., Schneeberger K.;
RT "Genome expansion of Arabis alpina linked with retrotransposition and
RT reduced symmetric DNA methylation.";
RL Nat. Plants 1:14023-14023(2015).
CC -!- SIMILARITY: Belongs to the peptidase C1 family.
CC {ECO:0000256|ARBA:ARBA00008455}.
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DR EMBL; CM002869; KFK43284.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A087HMD2; -.
DR MEROPS; C01.A13; -.
DR EnsemblPlants; KFK43284; KFK43284; AALP_AA1G104100.
DR Gramene; KFK43284; KFK43284; AALP_AA1G104100.
DR eggNOG; KOG1543; Eukaryota.
DR eggNOG; KOG4296; Eukaryota.
DR OMA; ETCCCAK; -.
DR OrthoDB; 5472443at2759; -.
DR Proteomes; UP000029120; Chromosome 1.
DR GO; GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd02248; Peptidase_C1A; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR Gene3D; 2.10.25.160; Granulin; 1.
DR InterPro; IPR000118; Granulin.
DR InterPro; IPR037277; Granulin_sf.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR025661; Pept_asp_AS.
DR InterPro; IPR000169; Pept_cys_AS.
DR InterPro; IPR025660; Pept_his_AS.
DR InterPro; IPR013128; Peptidase_C1A.
DR InterPro; IPR000668; Peptidase_C1A_C.
DR InterPro; IPR039417; Peptidase_C1A_papain-like.
DR InterPro; IPR013201; Prot_inhib_I29.
DR PANTHER; PTHR12411; CYSTEINE PROTEASE FAMILY C1-RELATED; 1.
DR PANTHER; PTHR12411:SF414; OS05G0508300 PROTEIN; 1.
DR Pfam; PF00396; Granulin; 1.
DR Pfam; PF08246; Inhibitor_I29; 1.
DR Pfam; PF00112; Peptidase_C1; 1.
DR PRINTS; PR00705; PAPAIN.
DR SMART; SM00277; GRAN; 1.
DR SMART; SM00848; Inhibitor_I29; 1.
DR SMART; SM00645; Pept_C1; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF57277; Granulin repeat; 1.
DR PROSITE; PS00640; THIOL_PROTEASE_ASN; 1.
DR PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
DR PROSITE; PS00639; THIOL_PROTEASE_HIS; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000029120};
KW Signal {ECO:0000256|SAM:SignalP};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807}.
FT SIGNAL 1..28
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 29..412
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018675060"
FT DOMAIN 35..92
FT /note="Cathepsin propeptide inhibitor"
FT /evidence="ECO:0000259|SMART:SM00848"
FT DOMAIN 119..334
FT /note="Peptidase C1A papain C-terminal"
FT /evidence="ECO:0000259|SMART:SM00645"
FT DOMAIN 351..408
FT /note="Granulins"
FT /evidence="ECO:0000259|SMART:SM00277"
SQ SEQUENCE 412 AA; 45285 MW; 0FA7BF65A4DCA159 CRC64;
MSTSSSSFVS LTFFFLLLVS SLISSTTSDD ISELFNDWCQ KHGKTYDSEE EKQHRIQIFK
DNHDFVTQHN RITNSTYSLS LNAFADLTHH EFKASRLGLS APLSSVMGTR QSLGFSVNVP
DSVDWRKKGA VTNVKDQGSC GACWSFSATG SIEGINQIVT GELISLSEQE LIDCDKSYND
GCNGGLMDYA FEFVIKNKGI DTEKDYPYQE RDGTCKKDKL KKRVVTIDSY AGVKENDEKA
LKEAVAAQPV SVGICGSERA FQLYSSGVFS GPCSTSLDHA VLIVGYGSQN GVDYWIVKNS
WGKSWGMDGF MHMQRNTGNS EGVCGINMLA SYPVKTHPNP PPPSPSGPTK CNLFTYCSAG
ETCCCARNLF GLCFSWKCCE IESAVCCKDG RHCCPNDYPV CDTTRSLCLK VF
//
