ID A0A087MH31_9GAMM Unreviewed; 1843 AA.
AC A0A087MH31;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=Alpha-2-macroglobulin domain-containing protein {ECO:0000259|SMART:SM01360};
GN ORFNames=N788_04665 {ECO:0000313|EMBL:KFL36184.1};
OS Arenimonas donghaensis DSM 18148 = HO3-R19.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Xanthomonadales;
OC Xanthomonadaceae; Arenimonas.
OX NCBI_TaxID=1121014 {ECO:0000313|EMBL:KFL36184.1, ECO:0000313|Proteomes:UP000029085};
RN [1] {ECO:0000313|Proteomes:UP000029085}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HO3-R19 {ECO:0000313|Proteomes:UP000029085};
RA Chen F., Wang G.;
RT "Genome sequencing of Arenimonas donghaensis.";
RL Submitted (AUG-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:KFL36184.1, ECO:0000313|Proteomes:UP000029085}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HO3-R19 {ECO:0000313|EMBL:KFL36184.1,
RC ECO:0000313|Proteomes:UP000029085};
RX PubMed=26380644; DOI=10.1186/s40793-015-0055-4;
RA Chen F., Wang H., Cao Y., Li X., Wang G.;
RT "High quality draft genomic sequence of Arenimonas donghaensis DSM
RT 18148(T).";
RL Stand. Genomic Sci. 10:59-59(2015).
CC -!- SIMILARITY: Belongs to the protease inhibitor I39 (alpha-2-
CC macroglobulin) family. Bacterial alpha-2-macroglobulin subfamily.
CC {ECO:0000256|ARBA:ARBA00010556}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KFL36184.1}.
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DR EMBL; AVCJ01000023; KFL36184.1; -; Genomic_DNA.
DR STRING; 1121014.N788_04665; -.
DR PATRIC; fig|1121014.3.peg.1820; -.
DR Proteomes; UP000029085; Unassembled WGS sequence.
DR GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR Gene3D; 2.20.130.20; -; 1.
DR Gene3D; 2.60.40.1930; -; 1.
DR InterPro; IPR041246; Bact_MG10.
DR InterPro; IPR001599; Macroglobln_a2.
DR InterPro; IPR002890; MG2.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR PANTHER; PTHR40094; ALPHA-2-MACROGLOBULIN HOMOLOG; 1.
DR PANTHER; PTHR40094:SF1; UBIQUITIN DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00207; A2M; 1.
DR Pfam; PF17973; bMG10; 1.
DR Pfam; PF01835; MG2; 1.
DR SMART; SM01360; A2M; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000029085}.
FT DOMAIN 1158..1248
FT /note="Alpha-2-macroglobulin"
FT /evidence="ECO:0000259|SMART:SM01360"
FT REGION 525..544
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1843 AA; 198416 MW; 6C2F94BDBCF69631 CRC64;
MLAVAETPPE LTSAGIVGGN FELVFDQPML TWATPNHGDA LRTTPEAACG WYWVDDTTLA
CDTGGMGTEP LRKATPYQVQ IGERLWSQAG QAFEPTTVTL VSSPPSLDAT TTDWRAGLPA
VLLRSSQPLA AADIRAVVDA RFENETIDYS LERVEPGQYD PPDSVTYRWM PTAWPARPGR
LRLSLRQGLR SPLGPALGDA DESLLDVAIN MPFRLLATSC ASHGPHADST DGALCSAQSD
VLLLFSRAPS DASLERVAAA LPKGLVLAEE PRDCDYRCYG QRSRNDAPAH AIRLASTLAG
TTLAFELPAG LDANDGSRLT GKTEVRLDVA SHPPGYRIEP SVHLALPGSN EATRVESRNP
EGRDHWKELS IGRRTRLVLD RLVVPAARET YGDARSPDPA WGVLRHGGLS LGGVVDGAEA
RATALPAFQL LVNRHGPDLL AWATEWADAG PVPGARLDVL ALSPQGKLKV VASAQTDADG
VALLSLPEPV AGQDVLQQDV LHLLRATQGR RVTVLPLHAT TGMKLRRSDG EDAPDWYRPP
RPDTSPAFGV TDRLLYRPGD TVNFRLWQRE RQLNTLRRIA PGTETELALS VPSDRPVRTW
TAVTDAWGSI AGEVALPANL RDGGYCIGEA DSLAHAWSPT GACFEVRRFE TQAMWATLAL
PTRVHRPGEQ VSMAIEGGYY SGGPAADAPL HVSGLLVPMA FEEAYPDFAG FTFIEPAAHE
ASEADPFKDL EVPRTVDGKG RAEVELTLPT RLEHDDGGED DSLTPLAFAQ IRVNAALMVG
GESGAFSPTA NLRIAAFDRY VGLRSEGDWH ALGETPVLEA VVVGFDGKSQ PGRRVEVRLE
DGDEQDAELL GRCTLVAGTA SPCDIAVPRP GYYVFVAESE GAAPTRLGRW FGRYAPDDED
EALAELSLVQ ASDGHSPARV RLRQPHARAS ALFVLEYDRV IRHWTQSVGT ETEIDVPVSS
ELAPGVTLRV MLRPALASAG QGLDAKTIDA AMRLAIPRAG SDGLALSVAD DSLAPSDSLR
LALHNRSDQA RLVVLSVVDD AVHQQMAALH PSLDPGGPDF LGSLSTWGEG GWHGLEAWQR
IANPFRSRSS LRQEPVAFAR PAPADAASDS LDTIEVTGSR LKRSDIFNEE PAYEVLERAP
ATAPGRDGPR VRSQFPDAAY WSPGIELAPG ERRELSISLP DNLTRWRVLA WSGDQADGFD
LSQATATTTL PVELRFGLPA RLFDGDRAEA SVSARNASDT PQRVALQVAV DGAGIARIDE
ASAMLSPFAA LSRPVPLAPT EPDSLDVLAR AETERGNDAL SSRVPVQSRW SEVMVPQVGW
LVSPVSLPLP ALPDDAHTPH LQVRVSAGTA AWRAGWLREL RDYPHRCWEQ TLSRALGAAL
ALQDAADRAD WPDAQAVIDE ALGAAPGFMD EQGHFHFFPP ARPWDVTGDL LLDAHTLRQF
GWLRRLGQAV PDGLHDDLRD DVAAQATRVA EAKDRTGLEA LAVGVAALAA EDGDPPAAAL
QRLWQDWNHL SWHARSELVQ AMSVAPDFAE SFRAGLQRLY AAGESRGLRR TIRDPRSFGW
AMGSDLRDQC AVTAALWSLD ASADRLPERQ AFLRGLQYLY AGGTSSLDTQ ASLHCLLALR
AVDAARGSVA TAATVALEHG PTSSTLVLDG QGAGAGWQGV AEASELALKP LGGDSATLNY
VAQLSYRQDQ ARVEARGVGL NIERRYSVLR DGRWQALSGT SARRGEWIRV TLQLQVPALR
HFVAITDTVP GGWATRDVGL AGVAGANVRE VADPGSWWFD TRQTGATEVR LYAESLPPGT
HEVHYFAQAQ HPGRYFAPPA VAELMYGRAS RANTAGDWVE IQP
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