ID A0A087N6X5_9SPHN Unreviewed; 783 AA.
AC A0A087N6X5;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 24-JAN-2024, entry version 41.
DE SubName: Full=3-hydroxybutyryl-CoA dehydrogenase {ECO:0000313|EMBL:KFL44878.1};
GN ORFNames=IL54_0244 {ECO:0000313|EMBL:KFL44878.1};
OS Sphingobium sp. ba1.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC Sphingomonadaceae; Sphingobium.
OX NCBI_TaxID=1522072 {ECO:0000313|EMBL:KFL44878.1, ECO:0000313|Proteomes:UP000029094};
RN [1] {ECO:0000313|EMBL:KFL44878.1, ECO:0000313|Proteomes:UP000029094}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ba1 {ECO:0000313|Proteomes:UP000029094};
RA Manzari C., Chiara M., Costanza A., Leoni C., Picardi E., Trotta M.,
RA Volpicella M., D'Erchia A.M., Horner D.S., Pesole G., Ceci L.R.;
RT "Draft genome sequence of a Kanamycin and Nickel resistant bacterium
RT Sphingobium species.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC Evidence={ECO:0000256|ARBA:ARBA00023693};
CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00005005}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KFL44878.1}.
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DR EMBL; JPPQ01000083; KFL44878.1; -; Genomic_DNA.
DR RefSeq; WP_004206971.1; NZ_JPPQ01000083.1.
DR AlphaFoldDB; A0A087N6X5; -.
DR PATRIC; fig|1522072.3.peg.3809; -.
DR eggNOG; COG1024; Bacteria.
DR eggNOG; COG1250; Bacteria.
DR OrthoDB; 5389341at2; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000029094; Unassembled WGS sequence.
DR GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR CDD; cd06558; crotonase-like; 1.
DR Gene3D; 1.10.1040.50; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR PANTHER; PTHR48075:SF7; 3-HYDROXYACYL-COA DEHYDROGENASE-RELATED; 1.
DR Pfam; PF00725; 3HCDH; 1.
DR Pfam; PF02737; 3HCDH_N; 1.
DR Pfam; PF00378; ECH_1; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW NAD {ECO:0000256|ARBA:ARBA00023027}.
FT DOMAIN 18..201
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 204..305
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
SQ SEQUENCE 783 AA; 83140 MW; 7891AE79178ECE00 CRC64;
MSEQAIKPVG APPETIKKVC VIGAGVMGAG IAAQVANAGV PVLLLDIVPK EGGDRDAVAK
GAVAKMLKTD PAPFMSKAAA KLVETGNIDD HLERVAECDW IVEAIVERLD IKQALYAKLE
QLKRPGTAVS SNTSTIPLGH LVEGRDDQFK QDFLITHFFN PPRYMRLIEI VTGPDTDTAV
ARRVSDFVDR KLGKRIVPAR DTPGFIANRI GTYWLAVAIN AAMDQGLTVE EADQIGGKPM
GVPKTGIFGL VDLVGVDLMP LLTKSLSSTL PAGDAYFDTV RPMPLVDRMI AEGFTGRKGK
GGFYAFDKAT KTKKALDLAT GEYRVSVKPA SLPGRAEKDL AALVAAPGKV GAYAWEILGK
VLSYAASLVG EAADNIVGID DAMKLGYNWK FGPFELIDRL GPGKLAERLA AEGRDVPAIL
KVAGDRPFYR VQDGRRQYLD AAGDYHDVVR PEGVLLLEDI KLHSQPILKN GSAALWDVGD
GVACLEFTGK MNALDGDVMK LIGQAIPVVQ DKFKALVVYN EGSNFSAGAN LGLALFALNI
AAWGEIEKLV AGGQQAYKAL KYALFPVVSA PAGMALGGGC EILLNSDAVQ AHAESYVGLV
ECGVGLIPGW GGCGEMIDRW RSSPGMPKGP MPAVAKVFET VSTATVAKSA AEAKEHGFLR
PSDGITMNRD RLLADAKAKA LELADGYKPP VAPEFRLPGA GGKSALSMAV EGFQARGLAT
SYDGVVSGAL ADVLTGGEKD LIDIVTEEDL LALERKAFMQ LVRDPRTQAR VEQMLVTGKP
LRN
//
