ID A0A087QIV4_APTFO Unreviewed; 1658 AA.
AC A0A087QIV4;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Clathrin heavy chain 1 {ECO:0000313|EMBL:KFM01158.1};
DE Flags: Fragment;
GN ORFNames=AS27_01092 {ECO:0000313|EMBL:KFM01158.1};
OS Aptenodytes forsteri (Emperor penguin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Sphenisciformes; Spheniscidae;
OC Aptenodytes.
OX NCBI_TaxID=9233 {ECO:0000313|EMBL:KFM01158.1, ECO:0000313|Proteomes:UP000053286};
RN [1] {ECO:0000313|EMBL:KFM01158.1, ECO:0000313|Proteomes:UP000053286}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_AS27 {ECO:0000313|EMBL:KFM01158.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane
CC {ECO:0000256|ARBA:ARBA00004180}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004180}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004180}. Membrane, coated pit
CC {ECO:0000256|ARBA:ARBA00004277}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004277}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004277}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the clathrin heavy chain family.
CC {ECO:0000256|ARBA:ARBA00009535}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KL225642; KFM01158.1; -; Genomic_DNA.
DR STRING; 9233.A0A087QIV4; -.
DR Proteomes; UP000053286; Unassembled WGS sequence.
DR GO; GO:0030132; C:clathrin coat of coated pit; IEA:InterPro.
DR GO; GO:0030130; C:clathrin coat of trans-Golgi network vesicle; IEA:InterPro.
DR GO; GO:0071439; C:clathrin complex; IEA:InterPro.
DR GO; GO:0032051; F:clathrin light chain binding; IEA:InterPro.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:UniProtKB-UniRule.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR Gene3D; 1.25.40.730; -; 1.
DR Gene3D; 2.130.10.110; Clathrin heavy-chain terminal domain; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 4.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000547; Clathrin_H-chain/VPS_repeat.
DR InterPro; IPR015348; Clathrin_H-chain_linker_core.
DR InterPro; IPR016025; Clathrin_H-chain_N.
DR InterPro; IPR022365; Clathrin_H-chain_propeller_rpt.
DR InterPro; IPR016341; Clathrin_heavy_chain.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR10292:SF6; CLATHRIN HEAVY CHAIN 2; 1.
DR PANTHER; PTHR10292; CLATHRIN HEAVY CHAIN RELATED; 1.
DR Pfam; PF00637; Clathrin; 7.
DR Pfam; PF09268; Clathrin-link; 1.
DR Pfam; PF13838; Clathrin_H_link; 1.
DR Pfam; PF01394; Clathrin_propel; 5.
DR PIRSF; PIRSF002290; Clathrin_H_chain; 1.
DR SMART; SM00299; CLH; 7.
DR SUPFAM; SSF48371; ARM repeat; 6.
DR SUPFAM; SSF50989; Clathrin heavy-chain terminal domain; 1.
DR PROSITE; PS50236; CHCR; 7.
PE 3: Inferred from homology;
KW Coated pit {ECO:0000256|ARBA:ARBA00023176};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000053286};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 317..340
FT /note="Clathrin heavy chain linker core motif"
FT /evidence="ECO:0000259|Pfam:PF09268"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFM01158.1"
FT NON_TER 1658
FT /evidence="ECO:0000313|EMBL:KFM01158.1"
SQ SEQUENCE 1658 AA; 189342 MW; 8FDA2F5405157C5D CRC64;
LQNLGINPAN IGFSTLTMES DKFICIREKV GEQAQVVIID MSDPTTPIRR PISAESAIMN
PASKVIALKA GKTLQIFNIE MKSKMKAHTM AEEVIFWKWI SVNTVALVTE TAVYHWSMEG
ESQPQKMFDR HASLAGCQII NYRTDEHQKW LLLIGISAQQ NRVVGAMQLY SVDRKVSQPI
EGHAAAFAEF KIEGNAKPST LFCFAVRSPA GGKLHIIEVG QPATGNQPFV KKAVDVFFPP
EAQTDFPVAM QIGIKHGVIY LITKYGYIHM YDLESGVCIY MNRISADTIF VTAPHEPTSG
IIGVNKKGQV LSVCVEEDNI VNYATNVLQN PDLGLRMAIR SNLAGAEELF ARKFNTLFAQ
GSYADAAKVA ASAPKGILRT SDTIRKFQSV PAQPGQASPL LQYFGILLDQ GQLNKFESLE
LCRPVLQQGR KQLLEKWLKE DKLECSEELG DLVKTADPTL ALSVYLRANV PNKVIQCFAE
TGQFQKIVLY AKKVGYTPDW IFLLRSVMRV SPEQGLQFSQ MLVQDEEPLA NINQIVDVFM
ENSLIQQCTS FLLDALKNNR PAEGHLQTRL LEMNLIHAPQ VADAILGNQM FTHYDRAHIA
QLCEKAGLLQ RALEHYTDLY DIKRAVVHTH LLNPEWLVNF FGSLSVEDSV ECLRAMLSAN
IRQNLQLCVQ VASKYHEQLG TQSLVELFES FKSYEGLFYF LGSIVNFSQD PDVHFKYIQA
ACKTGQIKEV ERICRESNCY NPERVKNFLK EAKLTDQLPL IIVCDRFDFV HDLVLYLYRN
NLQKYIEIYV QKVNPSRIPA VVGGLLDVDC SEDVIKNLIM VVRGQFSTDE LVAEVEKRNR
LKLLLPWLES RIHEGCEEPA THNALAKIYI DSNNNPERFL RENPYYDSRV VGKYCEKRDP
HLACVAYERG QCDLELIKVC NENSLFKSEA RYLVRRKDPE LWANVLEENN PFRRQLIDQV
VQTALSETQD PEEVSVTVKA FMTADLPNEL IELLEKIVLD NSVFSEHRNL QNLLILTAIK
ADRTRVMEYI NRLDNYDAPD IANIAISNEL YEEAFAIFRK FDVNTSAIQV LIEHIGNLDR
AYEFAERCNE PAVWSQLARA QLQKDLVKEA IDSYIKADDP SAYMEVVQAA NRNDNWEDLV
KFLQMARKKA RESYVETELI FALAKTNRLS ELEEFISGPN NAHIQQVGDR CYEEGMYEAA
KLLYNNVSNF ARLASTLVHL GEYQAAVDSG RKANSTRTWK EVCFACVDGK EFRLAQICGL
HIVIHADELE ELISYYQDRG YFEELIALLE AALGLERAHM GMFTELAILY SKFKPQKMRE
HLELFWSRVN IPKVLRAAEQ AHLWAELVFL YDKYEEYDNA IITMMNHPTD AWKEGQFKDI
IAKVANVELY YKALQFYLDY KPLLINDLLL VLSPRLDHTR TVNFFSKVNQ LLLVKPYLRS
VQNHNNKGVN EALNNLLTEE EDYQGLRASI DAYDNFDNIT LAQRLEKHEL IEFRRIAAYL
YKGNNRWKQS VELCKKDRLY KDAMQYAAES KDAELAEKLL QWFLEEGKQE CFAACLFTCY
DLLHPDVVLE LAWRHNIMDF AMPYFIQVMR EYLTKVDKLD ASESLRKEEE QVTEPTPIVF
GQQLMLTAGP SAVPPQANFP YGYTAPGFTQ PPVYGFNM
//
