ID   A0A087QIX7_APTFO        Unreviewed;      1309 AA.
AC   A0A087QIX7;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   24-JAN-2024, entry version 34.
DE   RecName: Full=RING-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012483};
DE            EC=2.3.2.27 {ECO:0000256|ARBA:ARBA00012483};
GN   ORFNames=AS27_03178 {ECO:0000313|EMBL:KFM01181.1};
OS   Aptenodytes forsteri (Emperor penguin).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Sphenisciformes; Spheniscidae;
OC   Aptenodytes.
OX   NCBI_TaxID=9233 {ECO:0000313|EMBL:KFM01181.1, ECO:0000313|Proteomes:UP000053286};
RN   [1] {ECO:0000313|EMBL:KFM01181.1, ECO:0000313|Proteomes:UP000053286}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_AS27 {ECO:0000313|EMBL:KFM01181.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC         [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC         cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC         EC=2.3.2.27; Evidence={ECO:0000256|ARBA:ARBA00000900};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; KL225644; KFM01181.1; -; Genomic_DNA.
DR   STRING; 9233.A0A087QIX7; -.
DR   Proteomes; UP000053286; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR   CDD; cd16541; RING-HC_RNF123; 1.
DR   CDD; cd12882; SPRY_RNF123; 1.
DR   Gene3D; 2.60.120.920; -; 1.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR043136; B30.2/SPRY_sf.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR045129; RNF123/RSPRY1-like.
DR   InterPro; IPR003877; SPRY_dom.
DR   InterPro; IPR035773; SPRY_RNF123.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR13363:SF5; E3 UBIQUITIN-PROTEIN LIGASE RNF123; 1.
DR   PANTHER; PTHR13363; RING FINGER AND SRY DOMAIN-CONTAINING; 1.
DR   Pfam; PF00622; SPRY; 1.
DR   Pfam; PF13920; zf-C3HC4_3; 1.
DR   SMART; SM00449; SPRY; 1.
DR   SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR   SUPFAM; SSF57850; RING/U-box; 1.
DR   PROSITE; PS50188; B302_SPRY; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   4: Predicted;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053286};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00175}.
FT   DOMAIN          75..255
FT                   /note="B30.2/SPRY"
FT                   /evidence="ECO:0000259|PROSITE:PS50188"
FT   DOMAIN          1256..1294
FT                   /note="RING-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50089"
FT   REGION          718..742
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1309 AA;  147969 MW;  940C8F9582EDB5CC CRC64;
     MTSRGAGTAF SRKNYRLSTE PEKSKVTGIV NSRLLNDYLH RVFTNADGNQ PAAAYRKHLT
     FQNLQEHLDR LLAEENGSED SRDQVAEGRL GPSTVVLDHT SGFEGLLLVD DDLLGVIGHS
     NFGSIRATTC VYKGKWIYEV LISSQGLMQI GWCTLNCRFN QEEGVGDTPD SYAYDGNRVR
     KWNVTTTNYG KSWAAGDIVS CLIDLDEGTI AFCLNGISLG TAFDNITRGA GMAYFPAISL
     SFKESVAFNF GSRPLRYPLV EGYRPLQDPP VADLVKARKL LGYLKNVIHI GIDVTEGKLV
     EKDTSMWQLQ GEPTVLITLA HIFNYFSPLM CKVYLVEDVL MTFLLSILER GGAVEAHPLI
     QQLLDLMWLL MEEYEVHECL KQLLMSLLRA YRFSPIIPDL GLQIHYLRLT IAVLKHEKSR
     KYLLSNVLFD VLRSVVFFYI KSPLRVEEAG LQELIPTTWW PNRFTKEGKE SKEVKEESAE
     ERLRRRAYER GCQRLKKRIE VVEGLQVQIL KLLLNNKDRG GGEASRYIFL NKFRKFLQEN
     ASNRGNLTVL CPPEYMVCFL HRLIAALRFF WDGHKVKTPA ALSSEEAYVP PQLFYNGKVD
     YFDLQRLGGL LSHLKKTLKD DLAAKANVLI DPAELQAVTM DDLDEDEESA TSAAQSQRPS
     AALAIGGALA RPGWLSSPTL GRANRFLSTA AVSLMNPRRP LGTLEKIKVR TLSVEQRTEE
     DIEGSHGNEG LLLGRPPEEP DQPITENSLL EVLDGIVMMY NLSVHQQLGK MVGVSDDVNE
     YAMALKDTEE KISRCPKRRR DIHEELLKSQ KVFSEKLNHL SRRLAWINVT IYSKEKMQDV
     YWLLRVCIRT IEHGDRTGSL FAFMPEFYLS VAMNSYSALK NYFSPVNSME ELPGYEETLM
     RLAAILAKHF ADSRIVGTDI RDSLMQALAS YVCYPHSLRA VERIPEEQRI SMMKNLLAPY
     EQRPWAQTNW ILVRLWRGCG FGYRYTRLPH LLKTKPEDAS LPSLQKPCPS TLLQRHMADL
     LRSDRDLAPS FLNSVLNQLN WAFSEFIGMI QEIQQAAERL ERNFVDSRQL KVCATCFDLS
     VSLLRVLEMT VTLAPEIFLD WNRPSSELLL RRLAQLLNQV LNRVTAERNL FDRVVNLRLP
     GLESVDHYPI LVAVTGILVR LLVDTDVQGA ERATAVLLAD PCFQLRSIQY LLGHAEPSAL
     AAAAPATDKR HFSLHTYTEY ISAEELAKVD KMLSHLSEES KQAAATTLPT SEEDLCPICY
     AHPISAIFRP CSHKSCKACI NQHLMNNKDC FFCKATITGV DDFTKPASS
//