ID A0A087QKA7_APTFO Unreviewed; 1211 AA.
AC A0A087QKA7;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=Delta-like protein {ECO:0000256|RuleBase:RU280815};
DE Flags: Fragment;
GN ORFNames=AS27_01241 {ECO:0000313|EMBL:KFM01661.1};
OS Aptenodytes forsteri (Emperor penguin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Sphenisciformes; Spheniscidae;
OC Aptenodytes.
OX NCBI_TaxID=9233 {ECO:0000313|EMBL:KFM01661.1, ECO:0000313|Proteomes:UP000053286};
RN [1] {ECO:0000313|EMBL:KFM01661.1, ECO:0000313|Proteomes:UP000053286}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_AS27 {ECO:0000313|EMBL:KFM01661.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Putative Notch ligand involved in the mediation of Notch
CC signaling. {ECO:0000256|RuleBase:RU280815}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU280815}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU280815}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; KL225716; KFM01661.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A087QKA7; -.
DR STRING; 9233.A0A087QKA7; -.
DR Proteomes; UP000053286; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005112; F:Notch binding; IEA:InterPro.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:InterPro.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd00054; EGF_CA; 13.
DR Gene3D; 2.10.25.140; -; 1.
DR Gene3D; 2.60.40.3510; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 15.
DR InterPro; IPR001774; DSL.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR026219; Jagged/Serrate.
DR InterPro; IPR011651; Notch_ligand_N.
DR InterPro; IPR001007; VWF_dom.
DR PANTHER; PTHR24049; CRUMBS FAMILY MEMBER; 1.
DR PANTHER; PTHR24049:SF22; DROSOPHILA CRUMBS HOMOLOG; 1.
DR Pfam; PF21700; DL-JAG_EGF-like; 1.
DR Pfam; PF01414; DSL; 1.
DR Pfam; PF00008; EGF; 10.
DR Pfam; PF12661; hEGF; 2.
DR Pfam; PF07657; MNNL; 1.
DR PRINTS; PR00010; EGFBLOOD.
DR PRINTS; PR02059; JAGGEDFAMILY.
DR SMART; SM00051; DSL; 1.
DR SMART; SM00181; EGF; 16.
DR SMART; SM00179; EGF_CA; 14.
DR SMART; SM00215; VWC_out; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 7.
DR SUPFAM; SSF57184; Growth factor receptor domain; 2.
DR PROSITE; PS00010; ASX_HYDROXYL; 10.
DR PROSITE; PS51051; DSL; 1.
DR PROSITE; PS00022; EGF_1; 15.
DR PROSITE; PS01186; EGF_2; 9.
DR PROSITE; PS50026; EGF_3; 14.
DR PROSITE; PS01187; EGF_CA; 3.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW ECO:0000256|RuleBase:RU280815};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|RuleBase:RU280815, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000053286};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU280815};
KW Signal {ECO:0000256|RuleBase:RU280815};
KW Transmembrane {ECO:0000256|RuleBase:RU280815, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|RuleBase:RU280815,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1056..1079
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 165..209
FT /note="DSL"
FT /evidence="ECO:0000259|PROSITE:PS51051"
FT DOMAIN 276..314
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 316..352
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 354..390
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 392..428
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 430..465
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 467..503
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 505..541
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 570..607
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 609..645
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 647..683
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 685..721
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 724..760
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 762..798
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 800..836
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 1087..1111
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1142..1211
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1142..1157
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1194..1211
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 167..176
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 180..192
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 200..209
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 304..313
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 342..351
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 380..389
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 418..427
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 434..444
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 455..464
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 493..502
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 531..540
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 597..606
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 635..644
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 673..682
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 711..720
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 750..759
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 788..797
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 826..835
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFM01661.1"
FT NON_TER 1211
FT /evidence="ECO:0000313|EMBL:KFM01661.1"
SQ SEQUENCE 1211 AA; 134105 MW; B71065B7ED59F0A2 CRC64;
VSRSTGYFEL QLNSVRNVNG ELFNGECCDG MKSPQNLDCT RDECDTYVKV CLKEYQAKIT
PVGPCNYGFG STPVLGGNIF YLNSNKYSHQ GRTPETGRIV IPFQFAWPRS FTLIIEAWDW
DNDTKAGEDL LIERVAHAGM INPEDRWKTL QFNGPVAHFE VQIRVKCDEN YYSALCNKFC
GPRDDFVGHY TCDQNGNKAC MEGWMGEECK QAVCKQGCNL LHGGCSTPGE CKCHYGWQGQ
FCDECVRYPG CAHGSCNEPW QCNCETNWGG LLCNKDLNYC GNHHPCLNGG TCMNTEPDEY
RCACPDGYSG KNCEIAEHAC VSNPCANGGI CHEISSGFKC HCPAGWSGPT CAIDIDECAS
NPCAQGGTCI DGVNAFECIC PQQWIGATCQ LDANECEGKP CVNAYSCKNL IGGYYCDCIP
GWTGVNCHIN INDCHGQCQH GGTCKDEVNG YHCLCPRGFT GKNCETETNE CESNPCQNGG
RCKDLMNGFS CLCSQGFSGV FCEMDIDFCE PNPCQNGAKC YDLGGDYYCA CPDDYDGKNC
SHLKDHCKNN SCKVIDSCTI EVFTNATQEG IRFISSNVCG PHGRCISQPG GNFTCACERG
FTGIYCHENI NDCLGKPCKN GGTCIDEVDS FRCFCSSGWE GELCDTNFND CSPNPCHNGG
RCIDLVNDFY CECKNDWKGK TCHSREYQCD ANTCSNGGTC YDDGDTFRCS CPPEWIGSTC
NTAKNSSCIP NPCMNGGTCV GSGDSFSCIC KEGWEGRTCT QNTNDCNPHP CYNGGICVDG
VNWFRCECAP GFAGPDCRIN IDECQSSPCG YGATCIDEIN GYRCTCPPGR IGPRCQEVIG
IGKPCWLKGM TFPHGSRWDQ ECNNCHCLDG RIDCTKVWCG KKPCLLHKHW DNSNNQCPMG
QECQEKYMKC FQPPCTDWGE CSASEPLPAN IKCLPNSGYL DNDCARITLI FNGDKVPQGT
TTENICSEIR YLPATRTVSR DRTLIILCDL SYSTENAVEV AISFVPHRDE QDNSLIQNAA
NTIVNAITKR QNSTVMLAVT EVKVETIVVG NSSSDYLVPI LCAVFSIVWL TCIIICVWWT
RKRRKERERS RPPREEGANN QWAPLNPIRN PIDRSYSNKD IRYECKNFIS PQKRTCDAVE
EYVEYEEEED EEEERDEEMD KFLSHKLAKP LPTKASDTSE SSPVKKSHQI GKMDNRSVKN
VNASNFEGSR D
//
