ID A0A087QSK5_APTFO Unreviewed; 564 AA.
AC A0A087QSK5;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=Frizzled-10 {ECO:0000313|EMBL:KFM04209.1};
DE Flags: Fragment;
GN ORFNames=AS27_14390 {ECO:0000313|EMBL:KFM04209.1};
OS Aptenodytes forsteri (Emperor penguin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Sphenisciformes; Spheniscidae;
OC Aptenodytes.
OX NCBI_TaxID=9233 {ECO:0000313|EMBL:KFM04209.1, ECO:0000313|Proteomes:UP000053286};
RN [1] {ECO:0000313|EMBL:KFM04209.1, ECO:0000313|Proteomes:UP000053286}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_AS27 {ECO:0000313|EMBL:KFM04209.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor Fz/Smo family.
CC {ECO:0000256|ARBA:ARBA00008077}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KL225859; KFM04209.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A087QSK5; -.
DR STRING; 9233.A0A087QSK5; -.
DR Proteomes; UP000053286; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd15037; 7tmF_FZD10; 1.
DR CDD; cd07462; CRD_FZ10; 1.
DR Gene3D; 1.10.2000.10; Frizzled cysteine-rich domain; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR015526; Frizzled/SFRP.
DR InterPro; IPR000539; Frizzled/Smoothened_7TM.
DR InterPro; IPR020067; Frizzled_dom.
DR InterPro; IPR036790; Frizzled_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR PANTHER; PTHR11309; FRIZZLED; 1.
DR PANTHER; PTHR11309:SF86; FRIZZLED-10; 1.
DR Pfam; PF01534; Frizzled; 1.
DR Pfam; PF01392; Fz; 1.
DR PRINTS; PR00489; FRIZZLED.
DR SMART; SM00063; FRI; 1.
DR SMART; SM01330; Frizzled; 1.
DR SUPFAM; SSF63501; Frizzled cysteine-rich domain; 1.
DR PROSITE; PS50038; FZ; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00090};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000053286};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687}.
FT TRANSMEM 210..234
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 246..265
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 294..319
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 339..359
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 379..406
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 427..448
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 486..506
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 12..133
FT /note="FZ"
FT /evidence="ECO:0000259|PROSITE:PS50038"
FT DOMAIN 210..513
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 132..165
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 17..78
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 25..71
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 62..100
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 89..130
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 93..117
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFM04209.1"
FT NON_TER 564
FT /evidence="ECO:0000313|EMBL:KFM04209.1"
SQ SEQUENCE 564 AA; 63817 MW; 54A7F47AA056FEC7 CRC64;
CTGISSIDID RPGDGRCQPI EIPMCKDIGY NMTRMPNLMG HENQREAAIQ LHEFAPLVEY
GCHSHLKFFL CSLYAPMCTE QVSTPIPACR VMCEQARLKC SPIMEQFNFK WPDSLDCSKL
PNKNDPNYLC MEAPNNGSDE PPRGSSMLPP MFRPQRPSSG HDLQQHKDSL SRTSCENPGK
FHHVEKSASC APLCTPGVDV YWSKDDKQFA VIWIAIWSIL CFFSSAFTVL TFLIDPQRFK
YPERPIIFLS MCYCVYSVGY IIRLFSGAES IACDRDSGQL YVIQEGLEST GCTIVFLVLY
YFGMASSLWW VILTLTWFLA AGKKWGHEAI EANSSYFHLA AWAIPAVKTI MILVMRRVAG
DELTGLCYVG SMDVNALTGF VLIPLACYLI IGTSFILSGF VALFHIRRVM KTGGENTDKL
EKLMVRIGVF SVLYTVPATC VIACYFYERL NMDYWKIVAT QQKCKMNNQT KNLDCMMNNS
IPAVEIFMVK IFMLLVVGIT SGMWIWTSKT LQSWQNVCSR RLKKRSRRKP ASVITSSGIY
KKPQHPQKTH LAKYESTLQP PTCV
//
