ID A0A087QTN3_APTFO Unreviewed; 201 AA.
AC A0A087QTN3;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Glucagon {ECO:0000313|EMBL:KFM04587.1};
DE Flags: Fragment;
GN ORFNames=AS27_06684 {ECO:0000313|EMBL:KFM04587.1};
OS Aptenodytes forsteri (Emperor penguin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Sphenisciformes; Spheniscidae;
OC Aptenodytes.
OX NCBI_TaxID=9233 {ECO:0000313|EMBL:KFM04587.1, ECO:0000313|Proteomes:UP000053286};
RN [1] {ECO:0000313|EMBL:KFM04587.1, ECO:0000313|Proteomes:UP000053286}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_AS27 {ECO:0000313|EMBL:KFM04587.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the glucagon family.
CC {ECO:0000256|ARBA:ARBA00008369}.
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DR EMBL; KL225902; KFM04587.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A087QTN3; -.
DR STRING; 9233.A0A087QTN3; -.
DR Proteomes; UP000053286; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR GO; GO:0032099; P:negative regulation of appetite; ISS:AgBase.
DR Gene3D; 6.10.250.590; -; 3.
DR InterPro; IPR015550; Glucagon.
DR InterPro; IPR000532; Glucagon_GIP_secretin_VIP.
DR PANTHER; PTHR11418; GLUCAGON; 1.
DR PANTHER; PTHR11418:SF0; PRO-GLUCAGON; 1.
DR Pfam; PF00123; Hormone_2; 3.
DR PRINTS; PR00275; GLUCAGON.
DR SMART; SM00070; GLUCA; 3.
DR PROSITE; PS00260; GLUCAGON; 2.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000053286};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..201
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5001828277"
FT DOMAIN 55..77
FT /note="Glucagon / GIP / secretin / VIP family"
FT /evidence="ECO:0000259|PROSITE:PS00260"
FT DOMAIN 166..188
FT /note="Glucagon / GIP / secretin / VIP family"
FT /evidence="ECO:0000259|PROSITE:PS00260"
FT REGION 27..57
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 29..52
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 201
FT /evidence="ECO:0000313|EMBL:KFM04587.1"
SQ SEQUENCE 201 AA; 23197 MW; B0E7FE3B6EC7EA6C CRC64;
MKMKSVYFVA GLLLMIVQGS WQNPLQDTEE KSRSFKASQS EPLDESRQLN EVKRHSQGTF
TSDYSKYLDT RRAQDFVQWL MSTKRNGQQG QEDKENDKFP DQLSSNAISK RHAEFERHAE
GTYTSDITSY LEGQAAKEFI AWLVNGRGRR DFPEKALVAE EMGRRHADGT FTSDINKVLD
DMAAKEFLKW LINTKVTQRC L
//
